{"entity": "researcher", "timestamp": "2026-09-24T06:48:00.594Z", "family": "Winblad", "given": "Bengt", "initials": "B", "orcid": "0000-0002-0011-1179", "affiliations": ["Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.", "Theme Inflammation and Aging, Karolinska University Hospital, Huddinge, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa53d96890814cab88c6adaf1aaf4b8d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa53d96890814cab88c6adaf1aaf4b8d"}}, "publications": [{"entity": "publication", "iuid": "c35597fd7be64f3ba4de9f422502dfde", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c35597fd7be64f3ba4de9f422502dfde.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c35597fd7be64f3ba4de9f422502dfde"}}, "title": "Blood biomarkers of Alzheimer's disease and progression across different stages of cognitive decline in the community.", "authors": [{"family": "Valletta", "given": "Martina", "initials": "M", "orcid": "0000-0003-0139-8287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c63a55168d4a35bdd9d91428e39448.json"}}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3473c98810f247f7805ea747af1fdbbe.json"}}, {"family": "Gregorio", "given": "Caterina", "initials": "C", "orcid": "0000-0002-8163-1634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a81270d6a50243c0a64044b16384c010.json"}}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Winblad", "given": "Bengt", "initials": "B", "orcid": "0000-0002-0011-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa53d96890814cab88c6adaf1aaf4b8d.json"}}, {"family": "Canevelli", "given": "Marco", "initials": "M"}, {"family": "Andersson", "given": "Sarah", "initials": "S"}, {"family": "Dale", "given": "Matilda", "initials": "M", "orcid": "0000-0002-5788-7744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ceec63ec0dea45eaa5ad3c4d34b10959.json"}}, {"family": "Fredolini", "given": "Claudia", "initials": "C", "orcid": "0000-0002-7674-2014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cda0965cae2344aa9aaf9b1c5605b378.json"}}, {"family": "Laukka", "given": "Erika J", "initials": "EJ"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Grande", "given": "Giulia", "initials": "G", "orcid": "0000-0001-6312-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/560ca11ae102481a8e29703d6c395553.json"}}], "type": "journal article", "published": "2025-11-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "10412", "issn-l": "2041-1723"}, "abstract": "Blood biomarkers of Alzheimer's disease (AD) are promising for dementia prediction, but their association with progression across intermediate stages of cognitive decline in the general population remains unclear. We followed 2148 dementia-free individuals from a Swedish population-based cohort for up to 16 years. Associations between baseline AD blood biomarkers and transitions between normal cognition, mild cognitive impairment (MCI), and dementia were examined. Lower amyloid-\u03b242/40 ratio and higher phosphorylated-tau181 (p-tau181), p-tau217, total-tau, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) were associated with faster progression from MCI to all-cause and AD dementia, with the strongest associations for NfL and p-tau217. Elevated NfL and GFAP were linked to reduced MCI reversion to normal cognition, whereas no biomarker was associated with MCI development from normal cognition. These findings show robust group-level associations and indicate that AD blood biomarkers may help stratify dementia risk at the MCI stage in the community.", "doi": "10.1038/s41467-025-66728-2", "pmid": "41276530", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12644782"}, {"db": "pii", "key": "10.1038/s41467-025-66728-2"}], "notes": [], "created": "2026-09-23T09:08:28.915Z", "modified": "2026-09-23T09:08:29.063Z"}, {"entity": "publication", "iuid": "edf36a43bbf54946b3637973de3b5c3f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/edf36a43bbf54946b3637973de3b5c3f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/edf36a43bbf54946b3637973de3b5c3f"}}, "title": "Blood-based biomarkers of Alzheimer's disease and incident dementia in the community.", "authors": [{"family": "Grande", "given": "Giulia", "initials": "G", "orcid": "0000-0001-6312-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/560ca11ae102481a8e29703d6c395553.json"}}, {"family": "Valletta", "given": "Martina", "initials": "M", "orcid": "0000-0003-0139-8287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c63a55168d4a35bdd9d91428e39448.json"}}, {"family": "Rizzuto", "given": "Debora", "initials": "D"}, {"family": "Xia", "given": "Xin", "initials": "X"}, {"family": "Qiu", "given": "Chengxuan", "initials": "C", "orcid": "0000-0003-1922-4912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4a3f19bc7e049b09dd1d1c8a5b2f621.json"}}, {"family": "Orsini", "given": "Nicola", "initials": "N"}, {"family": "Dale", "given": "Matilda", "initials": "M", "orcid": "0000-0002-5788-7744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ceec63ec0dea45eaa5ad3c4d34b10959.json"}}, {"family": "Andersson", "given": "Sarah", "initials": "S"}, {"family": "Fredolini", "given": "Claudia", "initials": "C", "orcid": "0000-0002-7674-2014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cda0965cae2344aa9aaf9b1c5605b378.json"}}, {"family": "Winblad", "given": "Bengt", "initials": "B", "orcid": "0000-0002-0011-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa53d96890814cab88c6adaf1aaf4b8d.json"}}, {"family": "Laukka", "given": "Erika J", "initials": "EJ"}, {"family": "Fratiglioni", "given": "Laura", "initials": "L"}, {"family": "Vetrano", "given": "Davide L", "initials": "DL", "orcid": "0000-0002-3099-4830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3473c98810f247f7805ea747af1fdbbe.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "31", "issue": "6", "pages": "2027-2035", "issn-l": "1078-8956"}, "abstract": "Evidence regarding the clinical validity of blood biomarkers of Alzheimer's disease (AD) in the general population is limited. We estimated the hazard and predictive performance of six AD blood biomarkers for incident all-cause and AD dementia-the ratio of amyloid-\u03b2 42 to amyloid-\u03b2 40 and levels of tau phosphorylated at T217 (p-tau217), tau phosphorylated at T181 (p-tau181), total tau, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP)-in a cohort of 2,148 dementia-free older adults from Sweden, who were followed for up to 16 years. In multi-adjusted Cox regression models, elevated baseline levels of p-tau181, p-tau217, NfL, and GFAP were associated with a significantly increased hazard for all-cause and AD dementia, displaying a non-linear dose-response relationship. Elevated concentrations of p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia, with negative predictive values exceeding 90% but low positive predictive values (PPVs). Combining p-tau217 with NfL or GFAP further improved prediction, with PPVs reaching 43%. Our findings suggest that these biomarkers have the potential to rule out impending dementia in community settings, but they might need to be combined with other biological or clinical markers to be used as screening tools.", "doi": "10.1038/s41591-025-03605-x", "pmid": "40140622", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12176656"}, {"db": "pii", "key": "10.1038/s41591-025-03605-x"}], "notes": [], "created": "2026-09-23T06:49:46.343Z", "modified": "2026-09-23T07:25:41.142Z"}, {"entity": "publication", "iuid": "0d651ce9e1de43608603ae0241f7fb50", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0d651ce9e1de43608603ae0241f7fb50.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0d651ce9e1de43608603ae0241f7fb50"}}, "title": "Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis.", "authors": [{"family": "Haytural", "given": "Hazal", "initials": "H", "orcid": "0000-0002-6805-6989", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/015b826ad6934481b97ec0fada56fcaf.json"}}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Schedin-Weiss", "given": "Sophia", "initials": "S"}, {"family": "Bereczki", "given": "Erika", "initials": "E"}, {"family": "Rezeli", "given": "Melinda", "initials": "M"}, {"family": "Unwin", "given": "Richard D", "initials": "RD"}, {"family": "Wang", "given": "Xusheng", "initials": "X"}, {"family": "Dammer", "given": "Eric B", "initials": "EB", "orcid": "0000-0003-2947-7606", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/173587b207be44c2a646799c4c833222.json"}}, {"family": "Johnson", "given": "Erik C B", "initials": "ECB"}, {"family": "Seyfried", "given": "Nicholas T", "initials": "NT", "orcid": "0000-0002-4507-624X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/299b298ea1b44a30908d9acff917bfa1.json"}}, {"family": "Winblad", "given": "Bengt", "initials": "B", "orcid": "0000-0002-0011-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa53d96890814cab88c6adaf1aaf4b8d.json"}}, {"family": "Tijms", "given": "Betty M", "initials": "BM", "orcid": "0000-0002-2612-1797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/803d2e2311394c50b47c43c5f6a4c425.json"}}, {"family": "Visser", "given": "Pieter Jelle", "initials": "PJ"}, {"family": "Frykman", "given": "Susanne", "initials": "S"}, {"family": "Tjernberg", "given": "Lars O", "initials": "LO", "orcid": "0000-0001-6889-4950", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7bba840aca5e43cfb0397240db95fff1.json"}}], "type": "journal article", "published": "2021-12-03", "journal": {"title": "Sci Data", "issn": "2052-4463", "volume": "8", "issue": "1", "pages": "312", "issn-l": "2052-4463"}, "abstract": "Mass spectrometry (MS)-based proteomics is a powerful tool to explore pathogenic changes of a disease in an unbiased manner and has been used extensively in Alzheimer disease (AD) research. Here, by performing a meta-analysis of high-quality proteomic studies, we address which pathological changes are observed consistently and therefore most likely are of great importance for AD pathogenesis. We retrieved datasets, comprising a total of 21,588 distinct proteins identified across 857 postmortem human samples, from ten studies using labeled or label-free MS approaches. Our meta-analysis findings showed significant alterations of 757 and 1,195 proteins in AD in the labeled and label-free datasets, respectively. Only 33 proteins, some of which were associated with synaptic signaling, had the same directional change across the individual studies. However, despite alterations in individual proteins being different between the labeled and the label-free datasets, several pathways related to synaptic signaling, oxidative phosphorylation, immune response and extracellular matrix were commonly dysregulated in AD. These pathways represent robust changes in the human AD brain and warrant further investigation.", "doi": "10.1038/s41597-021-01090-8", "pmid": "34862388", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8642431"}, {"db": "pii", "key": "10.1038/s41597-021-01090-8"}], "notes": [], "created": "2026-09-23T13:43:16.812Z", "modified": "2026-09-23T13:43:16.960Z"}]}