{"entity": "researcher", "timestamp": "2026-09-30T04:55:40.827Z", "family": "Nakamoto", "given": "Rei", "initials": "R", "orcid": "0000-0001-7807-6548", "affiliations": ["Infectious Disease Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.", "Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa3feef34c8849c59b9b01618a126397.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa3feef34c8849c59b9b01618a126397"}}, "publications": [{"entity": "publication", "iuid": "43b90d82d62b499c8850d584450ca96a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/43b90d82d62b499c8850d584450ca96a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/43b90d82d62b499c8850d584450ca96a"}}, "title": "Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways.", "authors": [{"family": "Sender", "given": "Vicky", "initials": "V", "orcid": "0000-0003-2174-946X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/504a59cfdc6e4d0ca06637cad238ebf6.json"}}, {"family": "Hentrich", "given": "Karina", "initials": "K", "orcid": "0000-0001-6660-7233", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/190bfde694054d50a3e638fb1179c46f.json"}}, {"family": "Pathak", "given": "Anuj", "initials": "A"}, {"family": "Tan Qian Ler", "given": "Alicia", "initials": "A", "orcid": "0000-0001-9298-4008", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ff7ffaa5c004717bf09fe3db393b24c.json"}}, {"family": "Embaie", "given": "Bethel Tesfai", "initials": "BT", "orcid": "0000-0002-7081-5032", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff9366370702439898a8a955f822c637.json"}}, {"family": "Lundstr\u00f6m", "given": "Susanna L", "initials": "SL"}, {"family": "Gaetani", "given": "Massimiliano", "initials": "M", "orcid": "0000-0001-5610-0797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a402c63fbe4f478daa286177f031b923.json"}}, {"family": "Bergstrand", "given": "Jan", "initials": "J"}, {"family": "Nakamoto", "given": "Rei", "initials": "R", "orcid": "0000-0001-7807-6548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa3feef34c8849c59b9b01618a126397.json"}}, {"family": "Sham", "given": "Lok-To", "initials": "LT"}, {"family": "Widengren", "given": "Jerker", "initials": "J"}, {"family": "Normark", "given": "Staffan", "initials": "S", "orcid": "0000-0001-7917-3921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30a03a285f3b4e7d8f8d8326f7ec6455.json"}}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}], "type": "journal article", "published": "2020-12-08", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "117", "issue": "49", "pages": "31386-31397", "issn-l": "0027-8424"}, "abstract": "Influenza A virus (IAV)-related mortality is often due to secondary bacterial infections, primarily by pneumococci. Here, we study how IAV-modulated changes in the lungs affect bacterial replication in the lower respiratory tract (LRT). Bronchoalveolar lavages (BALs) from coinfected mice showed rapid bacterial proliferation 4 to 6 h after pneumococcal challenge. Metabolomic and quantitative proteomic analyses demonstrated capillary leakage with efflux of nutrients and antioxidants into the alveolar space. Pneumococcal adaptation to IAV-induced inflammation and redox imbalance increased the expression of the pneumococcal chaperone/protease HtrA. Presence of HtrA resulted in bacterial growth advantage in the IAV-infected LRT and protection from complement-mediated opsonophagocytosis due to capsular production. Absence of HtrA led to growth arrest in vitro that was partially restored by antioxidants. Pneumococcal ability to grow in the IAV-infected LRT depends on the nutrient-rich milieu with increased levels of antioxidants such as ascorbic acid and its ability to adapt to and cope with oxidative damage and immune clearance.", "doi": "10.1073/pnas.2012265117", "pmid": "33229573", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7733805"}, {"db": "pii", "key": "2012265117"}], "notes": [], "created": "2026-09-23T09:44:34.693Z", "modified": "2026-09-23T10:18:50.742Z"}]}