{"entity": "researcher", "timestamp": "2026-08-20T21:08:50.283Z", "family": "Shyrokova", "given": "Lena", "initials": "L", "orcid": "0000-0002-0361-6359", "affiliations": ["Department of Experimental Medical Science, Lund University, Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9e14037d4da48408ecfa16d12742d1f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9e14037d4da48408ecfa16d12742d1f"}}, "publications": [{"entity": "publication", "iuid": "d5dd1820f3d64bba98b64bc4c1396191", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d5dd1820f3d64bba98b64bc4c1396191.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d5dd1820f3d64bba98b64bc4c1396191"}}, "title": "The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes.", "authors": [{"family": "Odai", "given": "Roni", "initials": "R", "orcid": "0009-0002-2280-3915", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/604a6d6e3cdb468d8c6acfb6a2e45ff9.json"}}, {"family": "Leemann", "given": "Mich\u00e8le", "initials": "M", "orcid": "0009-0008-9641-8837", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/124f42d408ce4e23aa91f3d82ab73f22.json"}}, {"family": "Al-Murad", "given": "Tamim", "initials": "T", "orcid": "0009-0009-9450-6734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09af3a6db1304f58ba96542af779c538.json"}}, {"family": "Abdullah", "given": "Minhal", "initials": "M", "orcid": "0000-0002-6018-314X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c8fb279f2df41d2a5d86e7afbab9592.json"}}, {"family": "Shyrokova", "given": "Lena", "initials": "L", "orcid": "0000-0002-0361-6359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9e14037d4da48408ecfa16d12742d1f.json"}}, {"family": "Tenson", "given": "Tanel", "initials": "T", "orcid": "0000-0002-0260-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44fd1d5f2b4f43c0a2067d75306c85ed.json"}}, {"family": "Hauryliuk", "given": "Vasili", "initials": "V", "orcid": "0000-0003-2389-5057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1884d638ebd34b34bcabc105ca2f4092.json"}}, {"family": "Durairaj", "given": "Janani", "initials": "J", "orcid": "0000-0002-1698-4556", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbc37e3024a34e18b93c50bd7ce6c3a7.json"}}, {"family": "Pereira", "given": "Joana", "initials": "J", "orcid": "0000-0002-5588-6588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18123de080c84f7fba8ca71f1f294773.json"}}, {"family": "Atkinson", "given": "Gemma C", "initials": "GC", "orcid": "0000-0002-4861-4584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1879e0a722045769cfca0dd00d611a8.json"}}], "type": "journal article", "published": "2025-10-03", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "11", "issue": "40", "pages": "eadz8560", "issn-l": "2375-2548"}, "abstract": "Viruses are the most abundant and genetically diverse entities on Earth, yet the functions and evolution of most viral proteins remain poorly understood. Their rapid evolution often obscures evolutionary relationships, limiting the ability to assign functions using sequence-based methods. Although the conservation of protein fold can reveal deep homologies, viral proteins remain underrepresented in structural databases. We address this by clustering viral sequences from RefSeq and predicting the structures of ~27,000 representative proteins using AlphaFold2 to create the Viral AlphaFold Database (VAD). We uncover conserved folds in diverse viruses infecting bacteria, archaea, and eukaryotes. We predict homodimers and make comparisons to the Protein Data Bank, providing data on oligomerization potential. We reveal considerable functional darkness in the viral protein universe and report the discovery and validation of an uncharacterized toxin-antitoxin system. The VAD provides a foundation for exploring viral structure-function relationships, including ancient folds shaping viral interactions across all life.", "doi": "10.1126/sciadv.adz8560", "pmid": "41032608", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12487901"}], "notes": [], "created": "2026-08-20T11:59:12.908Z", "modified": "2026-08-20T11:59:13.115Z"}, {"entity": "publication", "iuid": "231058f2f1c34fdd8acab4f9953bd175", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/231058f2f1c34fdd8acab4f9953bd175.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/231058f2f1c34fdd8acab4f9953bd175"}}, "title": "Author Correction: A virally encoded tRNA neutralizes the PARIS antiviral defence system.", "authors": [{"family": "Burman", "given": "Nathaniel", "initials": "N", "orcid": "0000-0002-3732-3159", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2921e21fc8ef475f9cbd046ccb11dcf3.json"}}, {"family": "Belukhina", "given": "Svetlana", "initials": "S"}, {"family": "Depardieu", "given": "Florence", "initials": "F"}, {"family": "Wilkinson", "given": "Royce A", "initials": "RA", "orcid": "0000-0001-8831-2081", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cda0fb4684e942d79debf5486540628e.json"}}, {"family": "Skutel", "given": "Mikhail", "initials": "M", "orcid": "0009-0002-1351-3238", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6cdbcc1afc64c7fae88bba6620dbfb7.json"}}, {"family": "Santiago-Frangos", "given": "Andrew", "initials": "A", "orcid": "0000-0001-9615-065X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c02de27075742ecbe9541c7cbc3b43c.json"}}, {"family": "Graham", "given": "Ava B", "initials": "AB"}, {"family": "Livenskyi", "given": "Alexei", "initials": "A"}, {"family": "Chechenina", "given": "Anna", "initials": "A"}, {"family": "Morozova", "given": "Natalia", "initials": "N"}, {"family": "Zahl", "given": "Trevor", "initials": "T"}, {"family": "Henriques", "given": "William S", "initials": "WS"}, {"family": "Buyukyoruk", "given": "Murat", "initials": "M"}, {"family": "Rouillon", "given": "Christophe", "initials": "C", "orcid": "0000-0003-4038-315X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fb44ad311244f2d93842681cbaba854.json"}}, {"family": "Saudemont", "given": "Baptiste", "initials": "B"}, {"family": "Shyrokova", "given": "Lena", "initials": "L", "orcid": "0000-0002-0361-6359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9e14037d4da48408ecfa16d12742d1f.json"}}, {"family": "Kurata", "given": "Tatsuaki", "initials": "T"}, {"family": "Hauryliuk", "given": "Vasili", "initials": "V", "orcid": "0000-0003-2389-5057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1884d638ebd34b34bcabc105ca2f4092.json"}}, {"family": "Severinov", "given": "Konstantin", "initials": "K"}, {"family": "Groseille", "given": "Justine", "initials": "J"}, {"family": "Thierry", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Koszul", "given": "Romain", "initials": "R", "orcid": "0000-0002-3086-1173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2defe1b450ba487f84a07d26891a0475.json"}}, {"family": "Tesson", "given": "Florian", "initials": "F", "orcid": "0000-0003-4038-1154", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c667e4e918d148ae92087f99501229ad.json"}}, {"family": "Bernheim", "given": "Aude", "initials": "A", "orcid": "0000-0003-0212-777X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6adce5915ff4e268b67ed3379152e3d.json"}}, {"family": "Bikard", "given": "David", "initials": "D", "orcid": "0000-0002-5729-1211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367fb56955dc4b1488154d318c019a90.json"}}, {"family": "Wiedenheft", "given": "Blake", "initials": "B", "orcid": "0000-0001-9297-5304", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3aa235e8b700472fb462141be55cefd8.json"}}, {"family": "Isaev", "given": "Artem", "initials": "A", "orcid": "0000-0002-9593-2745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0919905a7b544ecaaf7462c99f5c6583.json"}}], "type": "published erratum", "published": "2024-12-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "636", "issue": "8043", "pages": "E8", "issn-l": "0028-0836"}, "abstract": null, "doi": "10.1038/s41586-024-08427-4", "pmid": "39633059", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11655349"}, {"db": "pii", "key": "10.1038/s41586-024-08427-4"}], "notes": [], "created": "2026-08-20T08:59:07.560Z", "modified": "2026-08-20T08:59:07.694Z"}, {"entity": "publication", "iuid": "6732be56799f40b0b830a54511d116e7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6732be56799f40b0b830a54511d116e7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6732be56799f40b0b830a54511d116e7"}}, "title": "A virally encoded tRNA neutralizes the PARIS antiviral defence system.", "authors": [{"family": "Burman", "given": "Nathaniel", "initials": "N", "orcid": "0000-0002-3732-3159", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2921e21fc8ef475f9cbd046ccb11dcf3.json"}}, {"family": "Belukhina", "given": "Svetlana", "initials": "S"}, {"family": "Depardieu", "given": "Florence", "initials": "F"}, {"family": "Wilkinson", "given": "Royce A", "initials": "RA", "orcid": "0000-0001-8831-2081", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cda0fb4684e942d79debf5486540628e.json"}}, {"family": "Skutel", "given": "Mikhail", "initials": "M", "orcid": "0009-0002-1351-3238", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6cdbcc1afc64c7fae88bba6620dbfb7.json"}}, {"family": "Santiago-Frangos", "given": "Andrew", "initials": "A", "orcid": "0000-0001-9615-065X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c02de27075742ecbe9541c7cbc3b43c.json"}}, {"family": "Graham", "given": "Ava B", "initials": "AB"}, {"family": "Livenskyi", "given": "Alexei", "initials": "A"}, {"family": "Chechenina", "given": "Anna", "initials": "A"}, {"family": "Morozova", "given": "Natalia", "initials": "N"}, {"family": "Zahl", "given": "Trevor", "initials": "T"}, {"family": "Henriques", "given": "William S", "initials": "WS"}, {"family": "Buyukyoruk", "given": "Murat", "initials": "M"}, {"family": "Rouillon", "given": "Christophe", "initials": "C", "orcid": "0000-0003-4038-315X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fb44ad311244f2d93842681cbaba854.json"}}, {"family": "Saudemont", "given": "Baptiste", "initials": "B"}, {"family": "Shyrokova", "given": "Lena", "initials": "L", "orcid": "0000-0002-0361-6359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9e14037d4da48408ecfa16d12742d1f.json"}}, {"family": "Kurata", "given": "Tatsuaki", "initials": "T"}, {"family": "Hauryliuk", "given": "Vasili", "initials": "V", "orcid": "0000-0003-2389-5057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1884d638ebd34b34bcabc105ca2f4092.json"}}, {"family": "Severinov", "given": "Konstantin", "initials": "K"}, {"family": "Groseille", "given": "Justine", "initials": "J"}, {"family": "Thierry", "given": "Agn\u00e8s", "initials": "A"}, {"family": "Koszul", "given": "Romain", "initials": "R", "orcid": "0000-0002-3086-1173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2defe1b450ba487f84a07d26891a0475.json"}}, {"family": "Tesson", "given": "Florian", "initials": "F", "orcid": "0000-0003-4038-1154", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c667e4e918d148ae92087f99501229ad.json"}}, {"family": "Bernheim", "given": "Aude", "initials": "A", "orcid": "0000-0003-0212-777X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6adce5915ff4e268b67ed3379152e3d.json"}}, {"family": "Bikard", "given": "David", "initials": "D", "orcid": "0000-0002-5729-1211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367fb56955dc4b1488154d318c019a90.json"}}, {"family": "Wiedenheft", "given": "Blake", "initials": "B", "orcid": "0000-0001-9297-5304", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3aa235e8b700472fb462141be55cefd8.json"}}, {"family": "Isaev", "given": "Artem", "initials": "A", "orcid": "0000-0002-9593-2745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0919905a7b544ecaaf7462c99f5c6583.json"}}], "type": "journal article", "published": "2024-10-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "634", "issue": "8033", "pages": "424-431", "issn-l": "0028-0836"}, "abstract": "Viruses compete with each other for limited cellular resources, and some deliver defence mechanisms that protect the host from competing genetic parasites1. The phage antirestriction induced system (PARIS) is a defence system, often encoded in viral genomes, that is composed of a 55 kDa ABC ATPase (AriA) and a 35 kDa TOPRIM nuclease (AriB)2. However, the mechanism by which AriA and AriB function in phage defence is unknown. Here we show that AriA and AriB assemble into a 425 kDa supramolecular immune complex. We use cryo-electron microscopy to determine the structure of this complex, thereby explaining how six molecules of AriA assemble into a propeller-shaped scaffold that coordinates three subunits of AriB. ATP-dependent detection of foreign proteins triggers the release of AriB, which assembles into a homodimeric nuclease that blocks infection by cleaving host lysine transfer RNA. Phage T5 subverts PARIS immunity through expression of a lysine transfer RNA variant that is not cleaved by PARIS, thereby restoring viral infection. Collectively, these data explain how AriA functions as an ATP-dependent sensor that detects viral proteins and activates the AriB toxin. PARIS is one of an emerging set of immune systems that form macromolecular complexes for the recognition of foreign proteins, rather than foreign nucleic acids3.", "doi": "10.1038/s41586-024-07874-3", "pmid": "39111359", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11464382"}, {"db": "pii", "key": "10.1038/s41586-024-07874-3"}], "notes": [], "created": "2026-08-20T08:59:01.122Z", "modified": "2026-08-20T08:59:01.605Z"}, {"entity": "publication", "iuid": "1a559ed2dafd466d8e52c3a17f62d0f5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1a559ed2dafd466d8e52c3a17f62d0f5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1a559ed2dafd466d8e52c3a17f62d0f5"}}, "title": "The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems.", "authors": [{"family": "Ernits", "given": "Karin", "initials": "K"}, {"family": "Saha", "given": "Chayan Kumar", "initials": "CK", "orcid": "0000-0002-5357-517X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3d0b705fbd94f5a82d2825b0f7d40cb.json"}}, {"family": "Brodiazhenko", "given": "Tetiana", "initials": "T"}, {"family": "Chouhan", "given": "Bhanu", "initials": "B"}, {"family": "Shenoy", "given": "Aditi", "initials": "A", "orcid": "0000-0001-7748-2501", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35bef00b985a45d59602675316e3d706.json"}}, {"family": "Buttress", "given": "Jessica A", "initials": "JA", "orcid": "0000-0001-8822-6917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f7cee57e9d94c53b46aed566af418e7.json"}}, {"family": "Duque-Pedraza", "given": "Juli\u00e1n J", "initials": "JJ"}, {"family": "Bojar", "given": "Veda", "initials": "V"}, {"family": "Nakamoto", "given": "Jose A", "initials": "JA", "orcid": "0000-0001-8312-433X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/590d08398d614e9ca3307803cd263b8d.json"}}, {"family": "Kurata", "given": "Tatsuaki", "initials": "T"}, {"family": "Egorov", "given": "Artyom A", "initials": "AA"}, {"family": "Shyrokova", "given": "Lena", "initials": "L", "orcid": "0000-0002-0361-6359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9e14037d4da48408ecfa16d12742d1f.json"}}, {"family": "Johansson", "given": "Marcus J O", "initials": "MJO", "orcid": "0000-0001-7117-7426", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ee1c60ebb934dfd996e67a32790db16.json"}}, {"family": "Mets", "given": "Toomas", "initials": "T", "orcid": "0000-0002-6796-7000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbceebe30234575b3575ef4f44c0511.json"}}, {"family": "Rustamova", "given": "Aytan", "initials": "A"}, {"family": "D\u017eigurski", "given": "Jelisaveta", "initials": "J", "orcid": "0000-0003-2885-6241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ff5ff6b4a5a4b3ba1f08f4d34440d4c.json"}}, {"family": "Tenson", "given": "Tanel", "initials": "T", "orcid": "0000-0002-0260-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44fd1d5f2b4f43c0a2067d75306c85ed.json"}}, {"family": "Garcia-Pino", "given": "Abel", "initials": "A"}, {"family": "Strahl", "given": "Henrik", "initials": "H", "orcid": "0000-0003-4416-2178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17b2bf7837f7474dac625be9421a223e.json"}}, {"family": "Elofsson", "given": "Arne", "initials": "A", "orcid": "0000-0002-7115-9751", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/248e70e81bd64f31a5f83e6e329bba95.json"}}, {"family": "Hauryliuk", "given": "Vasili", "initials": "V", "orcid": "0000-0003-2389-5057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1884d638ebd34b34bcabc105ca2f4092.json"}}, {"family": "Atkinson", "given": "Gemma C", "initials": "GC", "orcid": "0000-0002-4861-4584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1879e0a722045769cfca0dd00d611a8.json"}}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "120", "issue": "33", "pages": "e2305393120", "issn-l": "0027-8424"}, "abstract": "Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile genetic elements. Type II TAs are encoded as bicistronic (two-gene) operons that encode two proteins: a toxin and a neutralizing antitoxin. Using our tool NetFlax (standing for Network-FlaGs for toxins and antitoxins), we have performed a large-scale bioinformatic analysis of proteinaceous TAs, revealing interconnected clusters constituting a core network of TA-like gene pairs. To understand the structural basis of toxin neutralization by antitoxins, we have predicted the structures of 3,419 complexes with AlphaFold2. Together with mutagenesis and functional assays, our structural predictions provide insights into the neutralizing mechanism of the hyperpromiscuous Panacea antitoxin domain. In antitoxins composed of standalone Panacea, the domain mediates direct toxin neutralization, while in multidomain antitoxins the neutralization is mediated by other domains, such as PAD1, Phd-C, and ZFD. We hypothesize that Panacea acts as a sensor that regulates TA activation. We have experimentally validated 16 NetFlax TA systems and used domain annotations and metabolic labeling assays to predict their potential mechanisms of toxicity (such as membrane disruption, and inhibition of cell division or protein synthesis) as well as biological functions (such as antiphage defense). We have validated the antiphage activity of a RosmerTA system encoded by Gordonia phage Kita, and used fluorescence microscopy to confirm its predicted membrane-depolarizing activity. The interactive version of the NetFlax TA network that includes structural predictions can be accessed at http://netflax.webflags.se/.", "doi": "10.1073/pnas.2305393120", "pmid": "37556498", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10440598"}], "notes": [], "created": "2026-08-20T09:31:27.979Z", "modified": "2026-08-20T09:31:28.324Z"}, {"entity": "publication", "iuid": "528de81a6f214d86a9366806efd87b77", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/528de81a6f214d86a9366806efd87b77.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/528de81a6f214d86a9366806efd87b77"}}, "title": "The structural basis of hyperpromiscuity in a core combinatorial network of Type II toxin-antitoxin and related phage defence systems", "authors": [{"family": "Ernits", "given": "Karin", "initials": "K", "orcid": "0000-0003-1072-4945", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f3dbd4a451c45878f71cb0b441c561d.json"}}, {"family": "Saha", "given": "Chayan Kumar", "initials": "CK", "orcid": "0000-0002-5357-517X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3d0b705fbd94f5a82d2825b0f7d40cb.json"}}, {"family": "Brodiazhenko", "given": "Tetiana", "initials": "T", "orcid": "0000-0002-2591-9588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8747a493473b4ebcabf9b1847be69e29.json"}}, {"family": "Chouhan", "given": "Bhanu", "initials": "B", "orcid": "0000-0002-3918-5925", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/68a24320b5684139a54e7700443360ac.json"}}, {"family": "Shenoy", "given": "Aditi", "initials": "A", "orcid": "0000-0001-7748-2501", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35bef00b985a45d59602675316e3d706.json"}}, {"family": "Duque-Pedraza", "given": "Julian J", "initials": "JJ", "orcid": "0009-0008-6943-2967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/726403acf6a14088b5a3f48ecda03004.json"}}, {"family": "Bojar", "given": "Veda", "initials": "V", "orcid": "0009-0009-0321-143X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83f7668b4f044fe689251d5bab9edf60.json"}}, {"family": "Nakamoto", "given": "Jose A", "initials": "JA", "orcid": "0000-0001-8312-433X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/590d08398d614e9ca3307803cd263b8d.json"}}, {"family": "Kurata", "given": "Tatsuaki", "initials": "T", "orcid": "0000-0001-5986-7141", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd3ed90eb741422db2af62827e8947e2.json"}}, {"family": "Egorov", "given": "Artyom", "initials": "A", "orcid": "0000-0001-5578-5384", "researcher": {"href": 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"Jelisaveta", "initials": "J", "orcid": "0000-0003-2885-6241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ff5ff6b4a5a4b3ba1f08f4d34440d4c.json"}}, {"family": "Tenson", "given": "Tanel", "initials": "T", "orcid": "0000-0002-0260-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44fd1d5f2b4f43c0a2067d75306c85ed.json"}}, {"family": "Garcia-Pino", "given": "Abel", "initials": "A", "orcid": "0000-0002-6280-1714", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5cbbb1848368486e803f0236d9127c06.json"}}, {"family": "Elofsson", "given": "Arne", "initials": "A", "orcid": "0000-0002-7115-9751", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/248e70e81bd64f31a5f83e6e329bba95.json"}}, {"family": "Hauryliuk", "given": "Vasili", "initials": "V", "orcid": "0000-0003-2389-5057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1884d638ebd34b34bcabc105ca2f4092.json"}}, {"family": "Atkinson", "given": "Gemma Catherine", "initials": "GC", "orcid": "0000-0002-4861-4584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1879e0a722045769cfca0dd00d611a8.json"}}], "type": "posted-content", "published": "2023-03-22", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.03.22.533649", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:44:41.759Z", "modified": "2026-08-20T10:44:42.195Z"}]}