{"entity": "researcher", "timestamp": "2026-08-25T09:42:18.888Z", "family": "Harkany", "given": "Tibor", "initials": "T", "orcid": "0000-0002-6637-5900", "affiliations": ["Department of Neuroscience, Karolinska Institutet, Solna, Sweden.", "Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/f93a408b60e744fab7e3ecc88f3ab4de.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/f93a408b60e744fab7e3ecc88f3ab4de"}}, "publications": [{"entity": "publication", "iuid": "3505a36a8a2f4e438b0bad9b6208098b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3505a36a8a2f4e438b0bad9b6208098b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3505a36a8a2f4e438b0bad9b6208098b"}}, "title": "A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology.", "authors": [{"family": "Petersen", "given": "Julian", "initials": "J", "orcid": "0000-0002-7444-0610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2df2dd8db04447fa78bf79bac1a17d2.json"}}, {"family": "Englmaier", "given": "Lukas", "initials": "L", "orcid": "0000-0002-0082-2616", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/749ce625110d4f3b8839cbb733906219.json"}}, {"family": "Artemov", "given": "Artem V", "initials": "AV"}, {"family": "Poverennaya", "given": "Irina", "initials": "I"}, {"family": "Mahmoud", "given": "Ruba", "initials": "R"}, {"family": "Bouderlique", "given": "Thibault", "initials": "T"}, {"family": "Tesarova", "given": "Marketa", "initials": "M", "orcid": "0000-0002-5200-7365", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e26a2a23d8454d6d9dd6e1a498788877.json"}}, {"family": "Deviatiiarov", "given": "Ruslan", "initials": "R", "orcid": "0000-0003-0019-2076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/049ccf52c8b54a098f99f13a37c43b12.json"}}, {"family": "Szilv\u00e1sy-Szab\u00f3", "given": "Anett", "initials": "A"}, {"family": "Akkuratov", "given": "Evgeny E", "initials": "EE"}, {"family": "Pajuelo Reguera", "given": "David", "initials": "D", "orcid": "0000-0002-7715-9402", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45df782ef520405d9415c463b2d331b1.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c306297a4a0490c84a1d748b9f302a2.json"}}, {"family": "Kaucka", "given": "Marketa", "initials": "M", "orcid": "0000-0002-8781-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a458c8d68ec049a287848d4051ff84e7.json"}}, {"family": "Kastriti", "given": "Maria Eleni", "initials": "ME"}, {"family": "Krivanek", "given": "Jan", "initials": "J", "orcid": "0000-0002-7590-187X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f33f0fc83079412580418299f8879226.json"}}, {"family": "Radaszkiewicz", "given": "Tomasz", "initials": "T", "orcid": "0000-0003-4850-9933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9dd0b5c08064cfa87205d3834a9d9bd.json"}}, {"family": "G\u00f6m\u00f6ryov\u00e1", "given": "Krist\u00edna", "initials": "K", "orcid": "0000-0003-4407-3917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6c751c1c5244d68a1aa28e249e581f2.json"}}, {"family": "Knauth", "given": "Sarah", "initials": "S"}, {"family": "Potesil", "given": "David", "initials": "D", "orcid": "0000-0003-0390-0904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dab523231d494d34ac17b5446719a311.json"}}, {"family": "Zdrahal", "given": "Zbynek", "initials": "Z"}, {"family": "Ganji", "given": "Ranjani Sri", "initials": "RS"}, {"family": "Grabowski", "given": "Anna", "initials": "A", "orcid": "0000-0001-7304-5697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d089c19710d7467194b18b6897ec4422.json"}}, {"family": "Buhl", "given": "Miriam E", "initials": "ME", "orcid": "0000-0003-0627-9228", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb226d8b7096471392cf53465baba018.json"}}, {"family": "Zikmund", "given": "Tomas", "initials": "T", "orcid": "0000-0003-2948-5198", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4b38496f264c418cb9ddd696b04cc03f.json"}}, {"family": "Kavkova", "given": "Michaela", "initials": "M", "orcid": "0000-0001-7435-9292", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e2e699409f24b488c1caef8b65bfc1f.json"}}, {"family": "Axelson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Lindgren", "given": "David", "initials": "D"}, {"family": "Kramann", "given": "Rafael", "initials": "R"}, {"family": "Kuppe", "given": "Christoph", "initials": "C", "orcid": "0000-0003-4597-9833", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f713e30a89c24e13a30bbed513f0bcf4.json"}}, {"family": "Erd\u00e9lyi", "given": "Ferenc", "initials": "F"}, {"family": "M\u00e1t\u00e9", "given": "Zolt\u00e1n", "initials": "Z"}, {"family": "Szab\u00f3", "given": "G\u00e1bor", "initials": "G"}, {"family": "Koehne", "given": "Till", "initials": "T"}, {"family": "Harkany", "given": "Tibor", "initials": "T", "orcid": "0000-0002-6637-5900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f93a408b60e744fab7e3ecc88f3ab4de.json"}}, {"family": "Fried", "given": "Kaj", "initials": "K", "orcid": "0000-0002-9997-7078", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e105f61b4238430f8796cddde76e109e.json"}}, {"family": "Kaiser", "given": "Jozef", "initials": "J", "orcid": "0000-0002-7397-125X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/254f4eaaabed4c129962666eae39778f.json"}}, {"family": "Boor", "given": "Peter", "initials": "P", "orcid": "0000-0001-9921-4284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b63df3a10ae4a30ace9ed532d5cbbe9.json"}}, {"family": "Fekete", "given": "Csaba", "initials": "C", "orcid": "0000-0002-8206-562X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/287c626305474cd2b978353f6142c6d0.json"}}, {"family": "Rozman", "given": "Jan", "initials": "J", "orcid": "0000-0002-8035-8904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3cc50094159441eca0b7a607b9b0d651.json"}}, {"family": "Kasparek", "given": "Petr", "initials": "P"}, {"family": "Prochazka", "given": "Jan", "initials": "J", "orcid": "0000-0003-4675-8995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25072706ca4845299319b9478d25ac06.json"}}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a4e65e5d3324132bba133349f00ae15.json"}}, {"family": "Bryja", "given": "Vitezslav", "initials": "V", "orcid": "0000-0002-9136-5085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1727f2bb33eb418eb3f700448c293f69.json"}}, {"family": "Gusev", "given": "Oleg", "initials": "O"}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9991e2eddb0840dca291de18a9d77d13.json"}}], "type": "journal article", "published": "2023-05-29", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "3092", "issn-l": "2041-1723"}, "abstract": "In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and mammals. Through the comparison of single nucleotide polymorphisms, we identify gene flow of FAME from Neandertals into modern humans. We conduct knockout experiments on animals and observe altered body weight and decreased energy expenditure in Fame knockout animals, corresponding to genome-wide association studies linking FAME with higher body mass index in humans. Gene expression and subcellular localization analyses reveal that FAME is a membrane-bound protein enriched in the kidneys. Although the gene knockout results in structurally normal kidneys, we detect higher albumin in urine and lowered ferritin in the blood. Through experimental validation, we confirm interactions between FAME and ferritin and show co-localization in vesicular and plasma membranes.", "doi": "10.1038/s41467-023-38663-7", "pmid": "37248239", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10226981"}, {"db": "pii", "key": "10.1038/s41467-023-38663-7"}], "notes": [], "created": "2026-08-21T11:49:24.558Z", "modified": "2026-08-21T11:49:25.693Z"}, {"entity": "publication", "iuid": "d21fe0af022344b29e0aa5dfd226d8c1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d21fe0af022344b29e0aa5dfd226d8c1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d21fe0af022344b29e0aa5dfd226d8c1"}}, "title": "HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment.", "authors": [{"family": "Johard", "given": "Helena", "initials": "H"}, {"family": "Omelyanenko", "given": "Anna", "initials": "A"}, {"family": "Fei", "given": "Gao", "initials": "G"}, {"family": "Zilberter", "given": "Misha", "initials": "M", "orcid": "0000-0001-7164-8312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c9182754d56463283774c15669b3fc4.json"}}, {"family": "Dave", "given": "Zankruti", "initials": "Z"}, {"family": "Abu-Youssef", "given": "Randa", "initials": "R", "orcid": "0000-0001-6162-830X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d33d83ecadf943f2ba61669aee0d31ff.json"}}, {"family": "Schmidt", "given": "Linn\u00e9a", "initials": "L"}, {"family": "Harisankar", "given": "Aditya", "initials": "A", "orcid": "0000-0001-6174-9611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1872d489e1d84a2cbb6f1297225010be.json"}}, {"family": "Vincent", "given": "C Theresa", "initials": "CT", "orcid": "0000-0002-7248-066X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/819bd3924a1a42b0b42d23233cfbd144.json"}}, {"family": "Walfridsson", "given": "Julian", "initials": "J"}, {"family": "Nelander", "given": "Sven", "initials": "S"}, {"family": "Harkany", "given": "Tibor", "initials": "T", "orcid": "0000-0002-6637-5900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f93a408b60e744fab7e3ecc88f3ab4de.json"}}, {"family": "Blomgren", "given": "Klas", "initials": "K", "orcid": "0000-0002-0476-7271", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7fd30a53f0624aa0956582ffc52a7c31.json"}}, {"family": "And\u00e4ng", "given": "Michael", "initials": "M", "orcid": "0000-0002-2886-7891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b33fbda4ef73424681617dfd7b54ffe9.json"}}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Mol. Cancer Res.", "issn": "1557-3125", "volume": "18", "issue": "10", "pages": "1522-1533", "issn-l": "1541-7786"}, "abstract": "Children suffering from neurologic cancers undergoing chemotherapy and radiotherapy are at high risk of reduced neurocognitive abilities likely via damage to proliferating neural stem cells (NSC). Therefore, strategies to protect NSCs are needed. We argue that induced cell-cycle arrest/quiescence in NSCs during cancer treatment can represent such a strategy. Here, we show that hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are dynamically expressed over the cell cycle in NSCs, depolarize the membrane potential, underlie spontaneous calcium oscillations and are required to maintain NSCs in the actively proliferating pool. Hyperpolarizing pharmacologic inhibition of HCN channels during exposure to ionizing radiation protects NSCs cells in neurogenic brain regions of young mice. In contrast, brain tumor-initiating cells, which also express HCN channels, remain proliferative during HCN inhibition. IMPLICATIONS: Our finding that NSCs can be selectively rescued while cancer cells remain sensitive to the treatment, provide a foundation for reduction of cognitive impairment in children with neurologic cancers.", "doi": "10.1158/1541-7786.MCR-20-0292", "pmid": "32665429", "labels": [], "xrefs": [{"db": "pii", "key": "1541-7786.MCR-20-0292"}], "notes": [], "created": "2026-08-20T12:14:19.364Z", "modified": "2026-08-21T09:32:07.659Z"}, {"entity": "publication", "iuid": "c7007d8367a94ed991de1e1aeddeb2a7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c7007d8367a94ed991de1e1aeddeb2a7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c7007d8367a94ed991de1e1aeddeb2a7"}}, "title": "Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants.", "authors": [{"family": "Korchynska", "given": "Solomiia", "initials": "S"}, {"family": "Krassnitzer", "given": "Maria", "initials": "M"}, {"family": "Malenczyk", "given": "Katarzyna", "initials": "K"}, {"family": "Prasad", "given": "Rashmi B", "initials": "RB"}, {"family": "Tretiakov", "given": "Evgenii O", "initials": "EO"}, {"family": "Rehman", "given": "Sabah", "initials": "S"}, {"family": "Cinquina", "given": "Valentina", "initials": "V"}, {"family": "Gernedl", "given": "Victoria", "initials": "V"}, {"family": "Farlik", "given": "Matthias", "initials": "M"}, {"family": "Petersen", "given": "Julian", "initials": "J"}, {"family": "Hannes", "given": "Sophia", "initials": "S"}, {"family": "Schachenhofer", "given": "Julia", "initials": "J"}, {"family": "Reisinger", "given": "Sonali N", "initials": "SN"}, {"family": "Zambon", "given": "Alice", "initials": "A"}, {"family": "Asplund", "given": "Olof", "initials": "O"}, {"family": "Artner", "given": "Isabella", "initials": "I"}, {"family": "Keimpema", "given": "Erik", "initials": "E"}, {"family": "Lubec", "given": "Gert", "initials": "G"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Bock", "given": "Christoph", "initials": "C"}, {"family": "Pollak", "given": "Daniela D", "initials": "DD"}, {"family": "Romanov", "given": "Roman A", "initials": "RA"}, {"family": "Pifl", "given": "Christian", "initials": "C"}, {"family": "Groop", "given": "Leif", "initials": "L"}, {"family": "H\u00f6kfelt", "given": "Tomas Gm", "initials": "TG"}, {"family": "Harkany", "given": "Tibor", "initials": "T", "orcid": "0000-0002-6637-5900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f93a408b60e744fab7e3ecc88f3ab4de.json"}}], "type": "journal article", "published": "2020-01-02", "journal": {"title": "EMBO J.", "issn": "1460-2075", "volume": "39", "issue": "1", "pages": "e100882", "issn-l": "0261-4189"}, "abstract": "Maternal drug abuse during pregnancy is a rapidly escalating societal problem. Psychostimulants, including amphetamine, cocaine, and methamphetamine, are amongst the illicit drugs most commonly consumed by pregnant women. Neuropharmacology concepts posit that psychostimulants affect monoamine signaling in the nervous system by their affinities to neurotransmitter reuptake and vesicular transporters to heighten neurotransmitter availability extracellularly. Exacerbated dopamine signaling is particularly considered as a key determinant of psychostimulant action. Much less is known about possible adverse effects of these drugs on peripheral organs, and if in utero exposure induces lifelong pathologies. Here, we addressed this question by combining human RNA-seq data with cellular and mouse models of neuroendocrine development. We show that episodic maternal exposure to psychostimulants during pregnancy coincident with the intrauterine specification of pancreatic \u03b2 cells permanently impairs their ability of insulin production, leading to glucose intolerance in adult female but not male offspring. We link psychostimulant action specifically to serotonin signaling and implicate the sex-specific epigenetic reprogramming of serotonin-related gene regulatory networks upstream from the transcription factor Pet1/Fev as determinants of reduced insulin production.", "doi": "10.15252/embj.2018100882", "pmid": "31750562", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6939201"}, {"db": "GEO", "key": "GSE140072"}], "notes": [], "created": "2026-08-21T12:53:51.290Z", "modified": "2026-08-21T12:53:51.349Z"}]}