{"entity": "researcher", "timestamp": "2026-09-23T23:13:49.336Z", "family": "Parmar", "given": "Malin", "initials": "M", "orcid": "0000-0001-5002-4199", "affiliations": ["Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, SE-221 84, Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8d36e78309f45f8879f07e42682b29d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8d36e78309f45f8879f07e42682b29d"}}, "publications": [{"entity": "publication", "iuid": "1d629cb35a5146c787baaa4ade6dd381", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1d629cb35a5146c787baaa4ade6dd381.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1d629cb35a5146c787baaa4ade6dd381"}}, "title": "Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery.", "authors": [{"family": "Alekseenko", "given": "Zhanna", "initials": "Z", "orcid": "0000-0002-6560-9699", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/445652e37bbe48729174f49e389b79b2.json"}}, {"family": "Dias", "given": "Jos\u00e9 M", "initials": "JM", "orcid": "0000-0002-1402-0323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/baa189d497af4380b7db4c1aba55ae80.json"}}, {"family": "Adler", "given": "Andrew F", "initials": "AF"}, {"family": "Kozhevnikova", "given": "Mariya", "initials": "M"}, {"family": "van Lunteren", "given": "Josina Anna", "initials": "JA"}, {"family": "Nolbrant", "given": "Sara", "initials": "S", "orcid": "0000-0003-2184-1741", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4659a9108d743a59cf24d5a5df71582.json"}}, {"family": "Jeggari", "given": "Ashwini", "initials": "A"}, {"family": "Vasylovska", "given": "Svitlana", "initials": "S", "orcid": "0000-0003-0682-3449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f1b1e3a159d40679255275a858f6fec.json"}}, {"family": "Yoshitake", "given": "Takashi", "initials": "T"}, {"family": "Kehr", "given": "Jan", "initials": "J"}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}}, {"family": "Alexeyenko", "given": "Andrey", "initials": "A", "orcid": "0000-0001-8812-6481", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8078f1505d9747e1ac76cf2f6d4ee606.json"}}, {"family": "Parmar", "given": "Malin", "initials": "M", "orcid": "0000-0001-5002-4199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8d36e78309f45f8879f07e42682b29d.json"}}, {"family": "Ericson", "given": "Johan", "initials": "J", "orcid": "0000-0002-8019-7127", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2963ca6a73bb409baea88ca67eeca936.json"}}], "type": "journal article", "published": "2022-06-01", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "3046", "issn-l": "2041-1723"}, "abstract": "Stem cell therapies for Parkinson's disease (PD) have entered first-in-human clinical trials using a set of technically related methods to produce mesencephalic dopamine (mDA) neurons from human pluripotent stem cells (hPSCs). Here, we outline an approach for high-yield derivation of mDA neurons that principally differs from alternative technologies by utilizing retinoic acid (RA) signaling, instead of WNT and FGF8 signaling, to specify mesencephalic fate. Unlike most morphogen signals, where precise concentration determines cell fate, it is the duration of RA exposure that is the key-parameter for mesencephalic specification. This concentration-insensitive patterning approach provides robustness and reduces the need for protocol-adjustments between hPSC-lines. RA-specified progenitors promptly differentiate into functional mDA neurons in vitro, and successfully engraft and relieve motor deficits after transplantation in a rat PD model. Our study provides a potential alternative route for cell therapy and disease modelling that due to its robustness could be particularly expedient when use of autologous- or immunologically matched cells is considered.", "doi": "10.1038/s41467-022-30777-8", "pmid": "35650213", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9160024"}, {"db": "pii", "key": "10.1038/s41467-022-30777-8"}], "notes": [], "created": "2026-09-23T09:56:17.450Z", "modified": "2026-09-23T10:30:52.184Z"}, {"entity": "publication", "iuid": "c8cb2040ab624607a18c99d0bae82d86", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c8cb2040ab624607a18c99d0bae82d86.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c8cb2040ab624607a18c99d0bae82d86"}}, "title": "Author Correction: Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.", "authors": [{"family": "Tiklov\u00e1", "given": "Katar\u00edna", "initials": "K"}, {"family": "Nolbrant", "given": "Sara", "initials": "S", "orcid": "0000-0003-2184-1741", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4659a9108d743a59cf24d5a5df71582.json"}}, {"family": "Fiorenzano", "given": "Alessandro", "initials": "A"}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Sharma", "given": "Yogita", "initials": "Y"}, {"family": "Heuer", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0300-7606", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/258221d35b8c419fa4759d7eeee333b9.json"}}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Hoban", "given": "Deirdre B", "initials": "DB"}, {"family": "Cardoso", "given": "Tiago", "initials": "T", "orcid": "0000-0003-2686-458X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4db727de3c2849c8a4e4b64ec2a187ec.json"}}, {"family": "Adler", "given": "Andrew F", "initials": "AF"}, {"family": "Birtele", "given": "Marcella", "initials": "M"}, {"family": "Lund\u00e9n-Miguel", "given": "Hilda", "initials": "H"}, {"family": "Volakakis", "given": "Nikolaos", "initials": "N"}, {"family": "Kirkeby", "given": "Agnete", "initials": "A"}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}, {"family": "Parmar", "given": "Malin", "initials": "M", "orcid": "0000-0001-5002-4199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8d36e78309f45f8879f07e42682b29d.json"}}], "type": "journal article", "published": "2020-07-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "11", "issue": "1", "pages": "3630", "issn-l": "2041-1723"}, "abstract": "An amendment to this paper has been published and can be accessed via a link at the top of the paper.", "doi": "10.1038/s41467-020-17421-z", "pmid": "32669619", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7363905"}, {"db": "pii", "key": "10.1038/s41467-020-17421-z"}], "notes": [], "created": "2026-09-23T13:52:40.881Z", "modified": "2026-09-23T13:52:40.946Z"}, {"entity": "publication", "iuid": "84f943c268304f2191d00a764095eb9e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/84f943c268304f2191d00a764095eb9e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/84f943c268304f2191d00a764095eb9e"}}, "title": "Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.", "authors": [{"family": "Tiklov\u00e1", "given": "Katar\u00edna", "initials": "K"}, {"family": "Nolbrant", "given": "Sara", "initials": "S", "orcid": "0000-0003-2184-1741", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4659a9108d743a59cf24d5a5df71582.json"}}, {"family": "Fiorenzano", "given": "Alessandro", "initials": "A"}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Sharma", "given": "Yogita", "initials": "Y"}, {"family": "Heuer", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0300-7606", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/258221d35b8c419fa4759d7eeee333b9.json"}}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Hoban", "given": "Deirdre B", "initials": "DB"}, {"family": "Cardoso", "given": "Tiago", "initials": "T", "orcid": "0000-0003-2686-458X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4db727de3c2849c8a4e4b64ec2a187ec.json"}}, {"family": "Adler", "given": "Andrew F", "initials": "AF"}, {"family": "Birtele", "given": "Marcella", "initials": "M"}, {"family": "Lund\u00e9n-Miguel", "given": "Hilda", "initials": "H"}, {"family": "Volakakis", "given": "Nikolaos", "initials": "N"}, {"family": "Kirkeby", "given": "Agnete", "initials": "A"}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}, {"family": "Parmar", "given": "Malin", "initials": "M", "orcid": "0000-0001-5002-4199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8d36e78309f45f8879f07e42682b29d.json"}}], "type": "journal article", "published": "2020-05-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "11", "issue": "1", "pages": "2434", "issn-l": "2041-1723"}, "abstract": "Cell replacement is a long-standing and realistic goal for the treatment of Parkinson's disease (PD). Cells for transplantation can be obtained from fetal brain tissue or from stem cells. However, after transplantation, dopamine (DA) neurons are seen to be a minor component of grafts, and it has remained difficult to determine the identity of other cell types. Here, we report analysis by single-cell RNA sequencing (scRNA-seq) combined with comprehensive histological analyses to characterize intracerebral grafts from human embryonic stem cells (hESCs) and fetal tissue after functional maturation in a pre-clinical rat PD model. We show that neurons and astrocytes are major components in both fetal and stem cell-derived grafts. Additionally, we identify a cell type closely resembling a class of recently identified perivascular-like cells in stem cell-derived grafts. Thus, this study uncovers previously unknown cellular diversity in a clinically relevant cell replacement PD model.", "doi": "10.1038/s41467-020-16225-5", "pmid": "32415072", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7229159"}, {"db": "pii", "key": "10.1038/s41467-020-16225-5"}], "notes": [], "created": "2026-09-23T07:37:31.639Z", "modified": "2026-09-23T07:37:31.854Z"}, {"entity": "publication", "iuid": "f47257d40a034c53baf53af1507c9e1f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f47257d40a034c53baf53af1507c9e1f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f47257d40a034c53baf53af1507c9e1f"}}, "title": "Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.", "authors": [{"family": "Tiklov\u00e1", "given": "Katar\u00edna", "initials": "K"}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Lahti", "given": "Laura", "initials": "L"}, {"family": "Fiorenzano", "given": "Alessandro", "initials": "A"}, {"family": "Nolbrant", "given": "Sara", "initials": "S"}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Volakakis", "given": "Nikolaos", "initials": "N"}, {"family": "Yokota", "given": "Chika", "initials": "C"}, {"family": "Hilscher", "given": "Markus M", "initials": "MM"}, {"family": "Hauling", "given": "Thomas", "initials": "T"}, {"family": "Holmstr\u00f6m", "given": "Fredrik", "initials": "F"}, {"family": "Joodmardi", "given": "Eliza", "initials": "E"}, {"family": "Nilsson", "given": "Mats", "initials": "M"}, {"family": "Parmar", "given": "Malin", "initials": "M", "orcid": "0000-0001-5002-4199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8d36e78309f45f8879f07e42682b29d.json"}}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2019-02-04", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "10", "issue": "1", "pages": "581", "issn-l": "2041-1723"}, "abstract": "Midbrain dopamine (mDA) neurons constitute a heterogenous group of cells that have been intensely studied, not least because their degeneration causes major symptoms in Parkinson's disease. Understanding the diversity of mDA neurons - previously well characterized anatomically - requires a systematic molecular classification at the genome-wide gene expression level. Here, we use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3, a marker for mDA neurons. Analyses include cells isolated during development up until adulthood and the results are validated by histological characterization of newly identified markers. This identifies seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons. Five of them express dopaminergic markers, while two express glutamatergic and GABAergic markers, respectively. Analysis also indicate evolutionary conservation of diversity in humans. This comprehensive molecular characterization will provide a valuable resource for elucidating mDA neuron subgroup development and function in the mammalian brain.", "doi": "10.1038/s41467-019-08453-1", "pmid": "30718509", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6362095"}, {"db": "pii", "key": "10.1038/s41467-019-08453-1"}], "notes": [], "created": "2026-09-23T06:38:21.932Z", "modified": "2026-09-23T06:38:22.034Z"}]}