{"entity": "researcher", "timestamp": "2026-09-23T15:41:16.587Z", "family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "affiliations": ["Division of Immunology and Allergy, Dept of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden anna.smed.sorensen@ki.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/f747dcba0d814f518dea6be7f16729c7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/f747dcba0d814f518dea6be7f16729c7"}}, "publications": [{"entity": "publication", "iuid": "82646e11f8fe457c8f73f7cc2ad8dba1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/82646e11f8fe457c8f73f7cc2ad8dba1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/82646e11f8fe457c8f73f7cc2ad8dba1"}}, "title": "Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19.", "authors": [{"family": "Yu", "given": "Meng", "initials": "M", "orcid": "0000-0002-9798-6624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f84fdd49f44048aabed4a6158dcbc054.json"}}, {"family": "Charles", "given": "Afandi", "initials": "A", "orcid": "0000-0003-0022-3303", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77e038d2bbad40b4a7245320d8ed3393.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c3d94a38dda465b83f13ec070fef017.json"}}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Azizmohammadi", "given": "Lida", "initials": "L"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R", "orcid": "0000-0002-0985-8658", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6886b0c153c940298130477dc0bbb86e.json"}}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Nie", "given": "Mu", "initials": "M"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b59c59772714231a670ba7c4f01e72c.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06fd44d1b18443a88b9fc5632989602d.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/53b1b006cbd5453892092be445705616.json"}}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Maecker", "given": "Holden", "initials": "H", "orcid": "0000-0003-0795-9946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/907c7565d5ae41c380024e1b01f61399.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97bff95cb9014c8fb848e3c1c470df5d.json"}}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5945a41c8836474a8decf9c8b8db52ab.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1304f32971904c4e901803d46c5f7ffe.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6265be732af0469d9d58bf5a46e8cf7d.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1fe004217b9b4c5ab49fae1023ddedf1.json"}}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f747dcba0d814f518dea6be7f16729c7.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "2164", "issn-l": "2041-1723"}, "abstract": "Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. We find that during acute infection SARS-CoV-2-specific circulating Tfh (cTfh) cells expand with disease severity. SARS-CoV-2-specific cTfh cell frequencies correlate with plasmablast frequencies and SARS-CoV-2 antibody titers, avidity and neutralization. Furthermore, cTfh cells but not other memory CD4 T cells, from severe patients better induce plasmablast differentiation and antibody production compared to cTfh cells from mild patients. However, virus-specific cTfh cell development is delayed in patients that display or later develop severe disease compared to those with mild disease, which correlates with delayed induction of high-avidity neutralizing antibodies. Our study suggests that impaired generation of functional virus-specific cTfh cells delays high-quality antibody production at an early stage, potentially enabling progression to severe disease.", "doi": "10.1038/s41467-023-37835-9", "pmid": "37061513", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10105364"}, {"db": "pii", "key": "10.1038/s41467-023-37835-9"}], "notes": [], "created": "2026-09-23T09:04:34.180Z", "modified": "2026-09-23T09:04:34.927Z"}, {"entity": "publication", "iuid": "0452659a9bb54a47b4350cd5c9249078", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0452659a9bb54a47b4350cd5c9249078.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0452659a9bb54a47b4350cd5c9249078"}}, "title": "Monocytes in sarcoidosis are potent tumour necrosis factor producers and predict disease outcome.", "authors": [{"family": "Lepzien", "given": "Rico", "initials": "R", "orcid": "0000-0001-8584-2917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccda0ac97543425da795d9ba88f84960.json"}}, {"family": "Liu", "given": "Sang", "initials": "S"}, {"family": "Czarnewski", "given": "Paulo", "initials": "P", "orcid": "0000-0001-8150-4021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/501677a1262c438aa4077b205bb39a72.json"}}, {"family": "Nie", "given": "Mu", "initials": "M"}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Baharom", "given": "Faezzah", "initials": "F", "orcid": "0000-0003-4513-3600", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eed9bff0092b4ae79cdc1932fc2ca9e0.json"}}, {"family": "Pourazar", "given": "Jamshid", "initials": "J", "orcid": "0000-0003-0041-4644", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f54a94f833f4b139053ce46d19f0987.json"}}, {"family": "Rankin", "given": "Gregory", "initials": "G", "orcid": "0000-0002-8753-830X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d06fa477efd4781812c316b2a25bb5f.json"}}, {"family": "Eklund", "given": "Anders", "initials": "A", "orcid": "0000-0002-7263-7057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fba997bc47244098aa5f96470872b407.json"}}, {"family": "Bottai", "given": "Matteo", "initials": "M", "orcid": "0000-0002-3531-2739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f99e997bd9f64033b06e9b812ab72c02.json"}}, {"family": "Kullberg", "given": "Susanna", "initials": "S", "orcid": "0000-0003-2844-4773", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8f33678d7c54cf1b2874b5e3f7293a7.json"}}, {"family": "Blomberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-2452-7347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ab86771e4eb466f802d4faaeed05d5e.json"}}, {"family": "Grunewald", "given": "Johan", "initials": "J", "orcid": "0000-0003-0473-3984", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/532d61b0fa4f4324abaaf1a67bcf95b2.json"}}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f747dcba0d814f518dea6be7f16729c7.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Eur. Respir. J.", "issn": "1399-3003", "volume": "58", "issue": "1", "issn-l": "0903-1936"}, "abstract": "Pulmonary sarcoidosis is an inflammatory disease characterised by granuloma formation and heterogeneous clinical outcome. Tumour necrosis factor (TNF) is a pro-inflammatory cytokine contributing to granuloma formation and high levels of TNF have been shown to associate with progressive disease. Mononuclear phagocytes (MNPs) are potent producers of TNF and highly responsive to inflammation. In sarcoidosis, alveolar macrophages have been well studied. However, MNPs also include monocytes/monocyte-derived cells and dendritic cells, which are poorly studied in sarcoidosis, despite their central role in inflammation.\n\nTo determine the role of pulmonary monocyte-derived cells and dendritic cells during sarcoidosis.\n\nWe performed in-depth phenotypic, functional and transcriptomic analysis of MNP subsets from blood and bronchoalveolar lavage (BAL) fluid from 108 sarcoidosis patients and 30 healthy controls. We followed the clinical development of patients and assessed how the repertoire and function of MNP subsets at diagnosis correlated with 2-year disease outcome.\n\nMonocytes/monocyte-derived cells were increased in blood and BAL of sarcoidosis patients compared to healthy controls. Interestingly, high frequencies of blood intermediate monocytes at time of diagnosis associated with chronic disease development. RNA sequencing analysis showed highly inflammatory MNPs in BAL of sarcoidosis patients. Furthermore, frequencies of BAL monocytes/monocyte-derived cells producing TNF without exogenous stimulation at time of diagnosis increased in patients that were followed longitudinally. In contrast to alveolar macrophages, the frequency of TNF-producing BAL monocytes/monocyte-derived cells at time of diagnosis was highest in sarcoidosis patients that developed progressive disease.\n\nOur data show that pulmonary monocytes/monocyte-derived cells are highly inflammatory and can be used as a predictor of disease outcome in sarcoidosis patients.", "doi": "10.1183/13993003.03468-2020", "pmid": "33446605", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8295505"}, {"db": "pii", "key": "13993003.03468-2020"}], "notes": [], "created": "2026-09-23T08:47:02.875Z", "modified": "2026-09-23T08:47:03.427Z"}]}