{"entity": "researcher", "timestamp": "2026-08-22T09:13:38.495Z", "family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A", "orcid": "0000-0002-5998-5700", "affiliations": ["Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5137f08ce7b4632aa2409148852618f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5137f08ce7b4632aa2409148852618f"}}, "publications": [{"entity": "publication", "iuid": "fa9c5d1a569f468ebda68f67a515d3b9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fa9c5d1a569f468ebda68f67a515d3b9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fa9c5d1a569f468ebda68f67a515d3b9"}}, "title": "TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells.", "authors": [{"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9a6eb8b1e3846938ac6ffeba8231be7.json"}}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A", "orcid": "0000-0002-5998-5700", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5137f08ce7b4632aa2409148852618f.json"}}, {"family": "Nguyen", "given": "Son", "initials": "S", "orcid": "0000-0002-0475-5158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/563175eaba7148b7816b90dbcb8fa578.json"}}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Wu", "given": "Vincent H", "initials": "VH", "orcid": "0000-0002-8640-6065", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa6136ee64f340b98cd54dfedf1160d9.json"}}, {"family": "Gostick", "given": "Emma", "initials": "E", "orcid": "0000-0002-3628-5824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6017423d47424552b7e50fc2ecd1f67b.json"}}, {"family": "Llewellyn-Lacey", "given": "Sian", "initials": "S", "orcid": "0000-0002-4703-0413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af57bac759494750a2c88baeb95c90e0.json"}}, {"family": "Hammer", "given": "Quirin", "initials": "Q", "orcid": "0000-0003-2968-6061", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd1d59f056c149db98064ff1b0b99ed6.json"}}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Vangeti", "given": "Sindhu", "initials": "S", "orcid": "0000-0003-3404-6878", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f234a13fb4fb443693add36d86c273e5.json"}}, {"family": "Yu", "given": "Meng", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Gaballa", "given": "Ahmed", "initials": "A", "orcid": "0000-0002-5277-5129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b062c2e7638440919938a93892cf7848.json"}}, {"family": "Uhlin", "given": "Michael", "initials": "M", "orcid": "0000-0002-2177-6727", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/116cfe482bb941159ee2e7175f1cd095.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d33bfbd945e647ac82e2d2699df02cb9.json"}}, {"family": "Brander", "given": "Christian", "initials": "C"}, {"family": "Nowak", "given": "Piotr", "initials": "P", "orcid": "0000-0003-2747-0734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b916fcba1024b208ed996cf957f499c.json"}}, {"family": "Goepfert", "given": "Paul A", "initials": "PA", "orcid": "0000-0001-8441-5737", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3914cf27200d4846b1cb5c505486fe95.json"}}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17fa6bdd651d4efb93f267863eda54fc.json"}}, {"family": "Betts", "given": "Michael R", "initials": "MR", "orcid": "0000-0002-7690-1484", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c646f9a798841e6aefdbff38bad73b3.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf1bb88eef764f8bb81bdd6d8a231113.json"}}], "type": "journal article", "published": "2020-07-03", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "5", "issue": "49", "issn-l": "2470-9468"}, "abstract": "CD8+ T cell exhaustion is a hallmark of many cancers and chronic infections. In mice, T cell factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection-associated HMG box (TOX) is required for the epigenetic remodeling and survival of exhausted CD8+ T cells. However, it has remained unclear to what extent these transcription factors play analogous roles in humans. In this study, we mapped the expression of TOX and TCF-1 as a function of differentiation and specificity in the human CD8+ T cell landscape. Here, we demonstrate that circulating TOX+ CD8+ T cells exist in most humans, but that TOX is not exclusively associated with exhaustion. Effector memory CD8+ T cells generally expressed TOX, whereas naive and early-differentiated memory CD8+ T cells generally expressed TCF-1. Cytolytic gene and protein expression signatures were also defined by the expression of TOX. In the context of a relentless immune challenge, exhausted HIV-specific CD8+ T cells commonly expressed TOX, often in clusters with various activation markers and inhibitory receptors, and expressed less TCF-1. However, polyfunctional memory CD8+ T cells specific for cytomegalovirus (CMV) or Epstein-Barr virus (EBV) also expressed TOX, either with or without TCF-1. A similar phenotype was observed among HIV-specific CD8+ T cells from individuals who maintained exceptional immune control of viral replication. Collectively, these data demonstrate that TOX is expressed by most circulating effector memory CD8+ T cell subsets and not exclusively linked to exhaustion.", "doi": "10.1126/sciimmunol.aba7918", "pmid": "32620560", "labels": [], "xrefs": [{"db": "pii", "key": "5/49/eaba7918"}], "notes": [], "created": "2026-08-21T12:23:34.438Z", "modified": "2026-08-21T12:23:34.912Z"}]}