{"entity": "researcher", "timestamp": "2026-08-20T20:57:38.643Z", "family": "Rask-Andersen", "given": "Mathias", "initials": "M", "orcid": "0000-0002-8008-4659", "affiliations": ["Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Box 256, 751 05, Uppsala, Sweden. mathias.rask-andersen@igp.uu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4efeec022fc40828f71781ecad2df00.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4efeec022fc40828f71781ecad2df00"}}, "publications": [{"entity": "publication", "iuid": "d81ca7a5afc947f893085bcf904db3c3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d81ca7a5afc947f893085bcf904db3c3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d81ca7a5afc947f893085bcf904db3c3"}}, "title": "Time-resolved Mendelian randomization detects substantial variation in the detrimental effect of obesity throughout life.", "authors": [{"family": "Karlsson", "given": "Torgny", "initials": "T", "orcid": "0000-0001-8095-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8b2bb8ecf4545ad946ae2203c870282.json"}}, {"family": "Hadizadeh", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-9855-7610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d0b9d82968f456798ee9dd0b1dfa7d9.json"}}, {"family": "Rask-Andersen", "given": "Mathias", "initials": "M", "orcid": "0000-0002-8008-4659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4efeec022fc40828f71781ecad2df00.json"}}, {"family": "Schmitz", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4480-891X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30e1b982f81a4c11ba59043beab3e4df.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}], "type": "journal article", "published": "2025-10-24", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "11", "issue": "43", "pages": "eadv0926", "issn-l": "2375-2548"}, "abstract": "The global burden of disease attributable to obesity continues to rise. The disease incidence is substantially higher in elderly populations, but how obesity affects disease risk across a lifetime is largely unknown. To quantify the long-term temporal impact of obesity, access to large-scale longitudinal cohorts spanning many decades would typically be required. However, these longitudinal studies are rare and may be heavily biased by the presence of unaccountable confounding. Here, we develop a method-time-resolved Mendelian randomization-to estimate the cumulative effect of body mass index on disease risk at different ages. Using the UK Biobank, we find strong age-varying patterns for type 2 diabetes mellitus, coronary artery disease, and atrial fibrillation, as well as for osteoarthritis. We demonstrate that some of the most notable temporal characteristics are sex specific, while other features are shared between sexes. Analyses suggest that these features can be manifestations of primary prevention strategies.", "doi": "10.1126/sciadv.adv0926", "pmid": "41134883", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12551696"}], "notes": [], "created": "2026-08-20T11:59:07.462Z", "modified": "2026-08-20T11:59:07.682Z"}, {"entity": "publication", "iuid": "a2c2d19225344675a0e02f2a47822dc1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a2c2d19225344675a0e02f2a47822dc1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a2c2d19225344675a0e02f2a47822dc1"}}, "title": "Illuminating the 'healthy obese' phenotype.", "authors": [{"family": "Rask-Andersen", "given": "Mathias", "initials": "M", "orcid": "0000-0002-8008-4659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4efeec022fc40828f71781ecad2df00.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "5", "issue": "2", "pages": "193-194", "issn-l": "2522-5812"}, "abstract": null, "doi": "10.1038/s42255-022-00733-3", "pmid": "36703016", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s42255-022-00733-3"}], "notes": [], "created": "2026-08-20T09:25:55.668Z", "modified": "2026-08-20T09:25:55.693Z"}, {"entity": "publication", "iuid": "901d0c0de7794ca9af712add9557b345", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/901d0c0de7794ca9af712add9557b345.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/901d0c0de7794ca9af712add9557b345"}}, "title": "A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens.", "authors": [{"family": "Liu", "given": "Wei", "initials": "W"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Rask-Andersen", "given": "Helge", "initials": "H"}, {"family": "Rask-Andersen", "given": "Mathias", "initials": "M", "orcid": "0000-0002-8008-4659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4efeec022fc40828f71781ecad2df00.json"}}], "type": "journal article", "published": "2021-12-01", "journal": {"title": "BMC Med", "issn": "1741-7015", "volume": "19", "issue": "1", "pages": "302", "issn-l": "1741-7015"}, "abstract": "Sensorineural hearing loss is one of the most common sensory deficiencies. However, the molecular contribution to age-related hearing loss is not fully elucidated.\n\nWe performed genome-wide association studies (GWAS) for hearing loss-related traits in the UK Biobank (N = 362,396) and selected a high confidence set of ten hearing-associated gene products for staining in human cochlear samples: EYA4, LMX1A, PTK2/FAK, UBE3B, MMP2, SYNJ2, GRM5, TRIOBP, LMO-7, and NOX4.\n\nAll proteins were found to be expressed in human cochlear structures. Our findings illustrate cochlear structures that mediate mechano-electric transduction of auditory stimuli, neuronal conductance, and neuronal plasticity to be involved in age-related hearing loss.\n\nOur results suggest common genetic variation to influence structural resilience to damage as well as cochlear recovery after trauma, which protect against accumulated damage to cochlear structures and the development of hearing loss over time.", "doi": "10.1186/s12916-021-02169-0", "pmid": "34847940", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8638543"}, {"db": "pii", "key": "10.1186/s12916-021-02169-0"}], "notes": [], "created": "2026-08-20T12:20:22.906Z", "modified": "2026-08-20T12:20:22.972Z"}, {"entity": "publication", "iuid": "8e6b0e2577da43849f6581246899f246", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8e6b0e2577da43849f6581246899f246.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8e6b0e2577da43849f6581246899f246"}}, "title": "Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.", "authors": [{"family": "Rask-Andersen", "given": "Mathias", "initials": "M", "orcid": "0000-0002-8008-4659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4efeec022fc40828f71781ecad2df00.json"}}, {"family": "Karlsson", "given": "Torgny", "initials": "T"}, {"family": "Ek", "given": "Weronica E", "initials": "WE"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2019-01-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "10", "issue": "1", "pages": "339", "issn-l": "2041-1723"}, "abstract": "Body mass and body fat composition are of clinical interest due to their links to cardiovascular- and metabolic diseases. Fat stored in the trunk has been suggested to be more pathogenic compared to fat stored in other compartments. In this study, we perform genome-wide association studies (GWAS) for the proportion of body fat distributed to the arms, legs and trunk estimated from segmental bio-electrical impedance analysis (sBIA) for 362,499 individuals from the UK Biobank. 98 independent associations with body fat distribution are identified, 29 that have not previously been associated with anthropometric traits. A high degree of sex-heterogeneity is observed and the effects of 37 associated variants are stronger in females compared to males. Our findings also implicate that body fat distribution in females involves mesenchyme derived tissues and cell types, female endocrine tissues as well as extracellular matrix maintenance and remodeling.", "doi": "10.1038/s41467-018-08000-4", "pmid": "30664634", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6341104"}, {"db": "pii", "key": "10.1038/s41467-018-08000-4"}], "notes": [], "created": "2026-08-20T08:50:34.732Z", "modified": "2026-08-20T08:50:34.827Z"}, {"entity": "publication", "iuid": "461111e242e64632bb34c5c8d7cfcaf5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/461111e242e64632bb34c5c8d7cfcaf5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/461111e242e64632bb34c5c8d7cfcaf5"}}, "title": "Genome-Wide Association Study of Body Fat Distribution identifies Novel Adiposity Loci and Sex-Specific Genetic Effects", "authors": [{"family": "Rask-Andersen", "given": "Mathias", "initials": "M", "orcid": "0000-0002-8008-4659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4efeec022fc40828f71781ecad2df00.json"}}, {"family": "Karlsson", "given": "Torgny", "initials": "T"}, {"family": "Ek", "given": "Weronica E", "initials": "WE"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "posted-content", "published": "2017-10-23", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/207498", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:07:47.044Z", "modified": "2026-08-20T11:07:47.105Z"}]}