{"entity": "researcher", "timestamp": "2026-09-23T15:56:56.592Z", "family": "Gordon", "given": "Max", "initials": "M", "orcid": "0000-0002-8080-5815", "affiliations": ["Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/f25fcb52a7a442379dda7fbc40b58808.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/f25fcb52a7a442379dda7fbc40b58808"}}, "publications": [{"entity": "publication", "iuid": "2657c6b7a6b940e180547a5408c2fa02", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2657c6b7a6b940e180547a5408c2fa02.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2657c6b7a6b940e180547a5408c2fa02"}}, "title": "Plasma protein profiling predicts cancer in patients with non-specific symptoms.", "authors": [{"family": "Wannberg", "given": "Fredrika", "initials": "F", "orcid": "0009-0001-8505-3122", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7745725fe4343e0965f95f93f145311.json"}}, {"family": "\u00c1lvez", "given": "Mar\u00eda Bueno", "initials": "MB", "orcid": "0000-0002-2669-7796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7d09e4780a445b9b432d494c76d07e8.json"}}, {"family": "Qvick", "given": "Alvida", "initials": "A", "orcid": "0000-0001-6688-947X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a35044600074308842f40b8e5746e51.json"}}, {"family": "Pongracz", "given": "Tamas", "initials": "T", "orcid": "0000-0002-8089-4352", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a51cf5d750e437e9751fe8807c09fec.json"}}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Adolfsson", "given": "Emma", "initials": "E", "orcid": "0000-0002-7954-0696", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8859eed6bd484335914958b9e80acd1c.json"}}, {"family": "Essehorn", "given": "Louise", "initials": "L"}, {"family": "Gordon", "given": "Max", "initials": "M", "orcid": "0000-0002-8080-5815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f25fcb52a7a442379dda7fbc40b58808.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Helenius", "given": "Gisela", "initials": "G"}, {"family": "Hjalmar", "given": "Viktoria", "initials": "V"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M", "orcid": "0000-0002-7858-8233", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a08650cb00404b6dba35959f3cb0a53c.json"}}, {"family": "Rosell", "given": "Axel", "initials": "A", "orcid": "0000-0001-6280-0562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48a8b0bd9a9e4294b5e4de28ef9044df.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0009-0008-9471-3234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/91cd1fc926dc4be6974170db786ab3c1.json"}}], "type": "journal article", "published": "2025-12-29", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "17", "issue": "1", "pages": "151", "issn-l": "2041-1723"}, "abstract": "Cancer detection is challenging, especially in patients with diffuse symptoms that overlap with non-malignant conditions. Here we show that plasma protein profiling can identify cancer among patients with non-specific symptoms. Using proximity extension assay-based proteomics of 1463 plasma proteins from 456 patients presenting with non-specific symptoms sampled prior to cancer diagnostic work-up and diagnosis, we identify 29 proteins associated with new cancer diagnoses. We develop a model able to stratify 160 cancer cases and 296 non-cancer cases with an area under the curve of 0.80, maintaining performance (0.82) in an independent replication cohort of 238 patients. The model also distinguishes cancer from autoimmune, inflammatory and infectious diseases. Designed as a triage tool, our model based on a blood test could help prioritize patients at higher cancer risk for rapid and highly sensitive diagnostic modalities such as positron emission tomography-computed tomography. These findings emphasize the potential of blood proteome profiling to support timely diagnosis and transform clinical medicine.", "doi": "10.1038/s41467-025-67688-3", "pmid": "41457066", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12774938"}, {"db": "pii", "key": "10.1038/s41467-025-67688-3"}], "notes": [], "created": "2026-09-23T13:26:16.784Z", "modified": "2026-09-23T13:26:17.022Z"}, {"entity": "publication", "iuid": "d0feb64cb8c84b08bdcdf4560f1e49a7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d0feb64cb8c84b08bdcdf4560f1e49a7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d0feb64cb8c84b08bdcdf4560f1e49a7"}}, "title": "Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers.", "authors": [{"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Norin", "given": "Nina Greilert", "initials": "NG"}, {"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c3d94a38dda465b83f13ec070fef017.json"}}, {"family": "Gordon", "given": "Max", "initials": "M", "orcid": "0000-0002-8080-5815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f25fcb52a7a442379dda7fbc40b58808.json"}}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/265c9b3e11de4fcaa270a0eb20faf65c.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6265be732af0469d9d58bf5a46e8cf7d.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2023-03-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "1577", "issn-l": "2041-1723"}, "abstract": "Vaccination offers protection against severe COVID-19 caused by SARS-CoV-2 omicron but is less effective against infection. Characteristics such as serum antibody titer correlation to protection, viral abundance and clearance of omicron infection in vaccinated individuals are scarce. We present a 4-week twice-weekly SARS-CoV-2 qPCR screening in 368 triple vaccinated healthcare workers. Spike-specific IgG levels, neutralization titers and mucosal spike-specific IgA-levels were determined at study start and qPCR-positive participants were sampled repeatedly for two weeks. 81 (cumulative incidence 22%) BA.1, BA.1.1 and BA.2 infections were detected. High serum antibody titers are shown to be protective against infection (p < 0.01), linked to reduced viral load (p < 0.01) and time to viral clearance (p < 0.05). Pre-omicron SARS-CoV-2 infection is independently associated to increased protection against omicron, largely mediated by mucosal spike specific IgA responses (nested models lr test p = 0.02 and 0.008). Only 10% of infected participants remain asymptomatic through the course of their infection. We demonstrate that high levels of vaccine-induced spike-specific WT antibodies are linked to increased protection against infection and to reduced viral load if infected, and suggest that the additional protection offered by pre-omicron SARS-CoV-2 infection largely is mediated by mucosal spike-specific IgA.", "doi": "10.1038/s41467-023-36984-1", "pmid": "36949041", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10031702"}, {"db": "pii", "key": "10.1038/s41467-023-36984-1"}], "notes": [], "created": "2026-09-23T08:54:06.322Z", "modified": "2026-09-23T08:54:06.466Z"}]}