{"entity": "researcher", "timestamp": "2026-11-12T14:49:39.732Z", "family": "Sigal", "given": "George B", "initials": "GB", "orcid": "0000-0001-7149-6400", "affiliations": ["Meso Scale Diagnostics, LLC., Rockville, MD, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1bdd57b1c144ee88add4986ec22ba49.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1bdd57b1c144ee88add4986ec22ba49"}}, "publications": [{"entity": "publication", "iuid": "5e010bc9bd3a4920ad315ed2ec136d15", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5e010bc9bd3a4920ad315ed2ec136d15.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5e010bc9bd3a4920ad315ed2ec136d15"}}, "title": "Plasma proteomics for biomarker discovery in childhood tuberculosis.", "authors": [{"family": "Fossati", "given": "Andrea", "initials": "A"}, {"family": "Wambi", "given": "Peter", "initials": "P"}, {"family": "Jaganath", "given": "Devan", "initials": "D"}, {"family": "Calderon", "given": "Roger", "initials": "R", "orcid": "0000-0001-8932-0489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f004638916a844eb815dbdb18ef51693.json"}}, {"family": "Castro", "given": "Robert", "initials": "R"}, {"family": "Mohapatra", "given": "Alexander", "initials": "A", "orcid": "0000-0003-0400-6146", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/797386110e33406896be06083504cd91.json"}}, {"family": "McKetney", "given": "Justin", "initials": "J", "orcid": "0000-0002-2405-8288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ee6e2b32dcf45a8af485c840da5a4e1.json"}}, {"family": "Luiz", "given": "Juaneta", "initials": "J"}, {"family": "Nerurkar", "given": "Rutuja", "initials": "R"}, {"family": "Nkereuwem", "given": "Esin", "initials": "E", "orcid": "0000-0001-9606-9069", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88c4d1af68ae44f59d5d659ea8cfaf56.json"}}, {"family": "Franke", "given": "Molly F", "initials": "MF", "orcid": "0000-0002-4890-5728", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/323c6e0fff6e49609925c7c2f292510d.json"}}, {"family": "Mousavian", "given": "Zaynab", "initials": "Z"}, {"family": "Collins", "given": "Jeffrey M", "initials": "JM"}, {"family": "Sigal", "given": "George B", "initials": "GB", "orcid": "0000-0001-7149-6400", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1bdd57b1c144ee88add4986ec22ba49.json"}}, {"family": "Segal", "given": "Mark R", "initials": "MR"}, {"family": "Kampman", "given": "Beate", "initials": "B", "orcid": "0000-0002-6546-4709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43579cdffc3042c6849a3ac2e5b34c6b.json"}}, {"family": "Wobudeya", "given": "Eric", "initials": "E"}, {"family": "Cattamanchi", "given": "Adithya", "initials": "A"}, {"family": "Ernst", "given": "Joel D", "initials": "JD", "orcid": "0000-0001-9951-6207", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00c9ec4930be46429677acf7d2c232b1.json"}}, {"family": "Zar", "given": "Heather J", "initials": "HJ"}, {"family": "Swaney", "given": "Danielle L", "initials": "DL", "orcid": "0000-0001-6119-6084", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56317207941d4aaf81ab4d55de5fcba4.json"}}, {"family": "COMBO Study Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2025-07-19", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "6657", "issn-l": "2041-1723"}, "abstract": "Failure to rapidly diagnose tuberculosis disease (TB) and initiate treatment is a driving factor of TB as a leading cause of death in children. Current TB diagnostic assays have poor performance in children, thus a global priority is the identification of novel non-sputum-based TB biomarkers. Here we use high-throughput proteomics to measure the plasma proteome for 511 children, with and without HIV, and across 4 countries, to distinguish TB status using standardized definitions. By employing a machine learning approach, we derive four parsimonious biosignatures encompassing 3 to 6 proteins that achieve AUCs of 0.87-0.88 and which all reach the minimum WHO target product profile accuracy thresholds for a TB screening test. This work provides insights into the unique host response in pediatric TB disease, as well as a non-sputum biosignature that could reduce delays in TB diagnosis and improve the detection and management of TB in children worldwide.", "doi": "10.1038/s41467-025-61515-5", "pmid": "40683862", "labels": {"Andrea Fossati": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC12276249"}, {"db": "pii", "key": "10.1038/s41467-025-61515-5"}], "notes": [], "created": "2026-11-06T08:02:57.559Z", "modified": "2026-11-06T08:02:58.010Z"}]}