{"entity": "researcher", "timestamp": "2026-08-20T21:37:56.696Z", "family": "Allen", "given": "Kaitlin N", "initials": "KN", "orcid": "0000-0001-8036-1110", "affiliations": ["Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee49cf351f0c4f0583cf4fbbc9bf6062.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee49cf351f0c4f0583cf4fbbc9bf6062"}}, "publications": [{"entity": "publication", "iuid": "5747b955d1ce4f45ab8564863b6011a9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5747b955d1ce4f45ab8564863b6011a9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5747b955d1ce4f45ab8564863b6011a9"}}, "title": "The Antarctic Weddell seal genome reveals evidence of selection on cardiovascular phenotype and lipid handling.", "authors": [{"family": "Noh", "given": "Hyun Ji", "initials": "HJ"}, {"family": "Turner-Maier", "given": "Jason", "initials": "J"}, {"family": "Schulberg", "given": "S Anne", "initials": "SA"}, {"family": "Fitzgerald", "given": "Michael L", "initials": "ML"}, {"family": "Johnson", "given": "Jeremy", "initials": "J"}, {"family": "Allen", "given": "Kaitlin N", "initials": "KN", "orcid": "0000-0001-8036-1110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee49cf351f0c4f0583cf4fbbc9bf6062.json"}}, {"family": "H\u00fcckst\u00e4dt", "given": "Luis A", "initials": "LA"}, {"family": "Batten", "given": "Annabelle J", "initials": "AJ"}, {"family": "Alfoldi", "given": "Jessica", "initials": "J", "orcid": "0000-0001-9713-6200", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fdea3b614934331a6398fb24feb54c6.json"}}, {"family": "Costa", "given": "Daniel P", "initials": "DP"}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Zapol", "given": "Warren M", "initials": "WM"}, {"family": "Buys", "given": "Emmanuel S", "initials": "ES"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}, {"family": "Hindle", "given": "Allyson G", "initials": "AG", "orcid": "0000-0002-1983-9573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49459b37810943aca91c847060596160.json"}}], "type": "journal article", "published": "2022-02-17", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "5", "issue": "1", "pages": "140", "issn-l": "2399-3642"}, "abstract": "The Weddell seal (Leptonychotes weddellii) thrives in its extreme Antarctic environment. We generated the Weddell seal genome assembly and a high-quality annotation to investigate genome-wide evolutionary pressures that underlie its phenotype and to study genes implicated in hypoxia tolerance and a lipid-based metabolism. Genome-wide analyses included gene family expansion/contraction, positive selection, and diverged sequence (acceleration) compared to other placental mammals, identifying selection in coding and non-coding sequence in five pathways that may shape cardiovascular phenotype. Lipid metabolism as well as hypoxia genes contained more accelerated regions in the Weddell seal compared to genomic background. Top-significant genes were SUMO2 and EP300; both regulate hypoxia inducible factor signaling. Liver expression of four genes with the strongest acceleration signals differ between Weddell seals and a terrestrial mammal, sheep. We also report a high-density lipoprotein-like particle in Weddell seal serum not present in other mammals, including the shallow-diving harbor seal.", "doi": "10.1038/s42003-022-03089-2", "pmid": "35177770", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8854659"}, {"db": "pii", "key": "10.1038/s42003-022-03089-2"}], "notes": [], "created": "2026-08-20T09:25:05.912Z", "modified": "2026-08-20T09:25:06.076Z"}]}