{"entity": "researcher", "timestamp": "2026-08-20T21:08:25.193Z", "family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "affiliations": ["Clinical Microbiomics A/S, Copenhagen, Denmark."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3"}}, "publications": [{"entity": "publication", "iuid": "327b76ce89e14812bcff35c6b96d4942", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/327b76ce89e14812bcff35c6b96d4942.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/327b76ce89e14812bcff35c6b96d4942"}}, "title": "The association between the gut microbiome and 24-hour blood pressure measurements in the SCAPIS study", "authors": [{"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Holm", "given": "Jacob B", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2023-12-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.12.08.23299598", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:50:52.048Z", "modified": "2026-08-20T10:50:52.175Z"}, {"entity": "publication", "iuid": "8af06b272b154fac9f50b3bc455e6b3e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8af06b272b154fac9f50b3bc455e6b3e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8af06b272b154fac9f50b3bc455e6b3e"}}, "title": "Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort.", "authors": [{"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF"}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G"}, {"family": "J\u00f6nsson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-8298-539X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6a28f0ea6264c3893bbd362355ec85c.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-3873-7943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13bd5f11f5cc4420a1c57183bb8323c9.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Pita", "given": "Sara", "initials": "S", "orcid": "0000-0002-5163-7306", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc61e356bdb84493813be139de58922a.json"}}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Holm", "given": "Jacob B", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Ericson", "given": "Ulrika", "initials": "U"}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Ottosson", "given": "Filip", "initials": "F"}, {"family": "Larsson", "given": "Anna", "initials": "A"}, {"family": "Ericson", "given": "Dan", "initials": "D", "orcid": "0000-0003-0356-2351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a89ea38f5bb6487abe6f6973a3886019.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1fa67d262984bccbb6b45e913a09393.json"}}, {"family": "Malinovschi", "given": "Andrei", "initials": "A", "orcid": "0000-0002-4098-7765", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/394a2f4dcf5847ce98e1c758f5c4d710.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "journal article", "published": "2023-08-08", "journal": {"title": "Circulation", "issn": "1524-4539", "volume": "148", "issue": "6", "pages": "459-472", "issn-l": "0009-7322"}, "abstract": "Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.\n\nWe conducted a cross-sectional study of 8973 participants (50 to 65 years of age) without overt atherosclerotic disease from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary atherosclerosis was measured using coronary artery calcium score and coronary computed tomography angiography. Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of fecal samples, and associations with coronary atherosclerosis were evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflammatory markers, metabolites, and corresponding species in saliva.\n\nThe mean age of the study sample was 57.4 years, and 53.7% were female. Coronary artery calcification was detected in 40.3%, and 5.4% had at least 1 stenosis with >50% occlusion. Sixty-four species were associated with coronary artery calcium score independent of cardiovascular risk factors, with the strongest associations observed for Streptococcus anginosus and Streptococcus oralis subsp oralis (P<1\u00d710-5). Associations were largely similar across coronary computed tomography angiography-based measurements. Out of the 64 species, 19 species, including streptococci and other species commonly found in the oral cavity, were associated with high-sensitivity C-reactive protein plasma concentrations, and 16 with neutrophil counts. Gut microbial species that are commonly found in the oral cavity were negatively associated with plasma indole propionate and positively associated with plasma secondary bile acids and imidazole propionate. Five species, including 3 streptococci, correlated with the same species in saliva and were associated with worse dental health in the Malm\u00f6 Offspring Dental Study. Microbial functional potential of dissimilatory nitrate reduction, anaerobic fatty acid \u03b2-oxidation, and amino acid degradation were associated with coronary artery calcium score.\n\nThis study provides evidence of an association of a gut microbiota composition characterized by increased abundance of Streptococcus spp and other species commonly found in the oral cavity with coronary atherosclerosis and systemic inflammation markers. Further longitudinal and experimental studies are warranted to explore the potential implications of a bacterial component in atherogenesis.", "doi": "10.1161/CIRCULATIONAHA.123.063914", "pmid": "37435755", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10399955"}], "notes": [], "created": "2026-08-20T12:16:07.214Z", "modified": "2026-08-20T12:16:07.530Z"}, {"entity": "publication", "iuid": "d03b30b31a6340329b06b1fd7ac19066", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d03b30b31a6340329b06b1fd7ac19066.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d03b30b31a6340329b06b1fd7ac19066"}}, "title": "Author Correction: An online atlas of human plasma metabolite signatures of gut microbiome composition.", "authors": [{"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Bak Holm", "given": "Jacob", "initials": "J", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "published erratum", "published": "2023-05-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "2971", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-023-38607-1", "pmid": "37221166", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10205746"}, {"db": "pii", "key": "10.1038/s41467-023-38607-1"}], "notes": [], "created": "2026-08-20T08:52:39.931Z", "modified": "2026-08-20T08:52:40.062Z"}, {"entity": "publication", "iuid": "e72b254291b34e53ae929198d59868ec", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e72b254291b34e53ae929198d59868ec.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e72b254291b34e53ae929198d59868ec"}}, "title": "An online atlas of human plasma metabolite signatures of gut microbiome composition.", "authors": [{"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Bak Holm", "given": "Jacob", "initials": "J", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "journal article", "published": "2022-09-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "5370", "issn-l": "2041-1723"}, "abstract": "Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas ( https://gutsyatlas.serve.scilifelab.se/ ). We exemplify the potential of this resource by presenting novel associations between dietary factors and oral medication with the gut microbiome, and microbial species strongly associated with the uremic toxin p-cresol sulfate. This resource can be used as the basis for targeted studies of perturbation of specific metabolites and for identification of candidate plasma biomarkers of gut microbiota composition.", "doi": "10.1038/s41467-022-33050-0", "pmid": "36151114", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9508139"}, {"db": "pii", "key": "10.1038/s41467-022-33050-0"}], "notes": [], "created": "2026-08-20T08:52:18.907Z", "modified": "2026-08-20T08:52:19.472Z"}, {"entity": "publication", "iuid": "6288d2088a5f4c98937d224c432a65b9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6288d2088a5f4c98937d224c432a65b9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6288d2088a5f4c98937d224c432a65b9"}}, "title": "Streptococcus species abundance in the gut is linked to subclinical coronary atherosclerosis in 8973 participants from the SCAPIS cohort", "authors": [{"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "J\u00f6nsson", "given": "Daniel", "initials": "D"}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-1914-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edbc11d091084a2392a8dfc062f070e8.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Pita", "given": "Sara", "initials": "S"}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Holm", "given": "Jacob B", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB"}, {"family": "Ericson", "given": "Ulrika", "initials": "U"}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Larsson", "given": "Anna", "initials": "A"}, {"family": "Ericson", "given": "Dan", "initials": "D"}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2100-2446", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af7e26452d9f4f6b959164c5933db734.json"}}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1fa67d262984bccbb6b45e913a09393.json"}}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2022-05-25", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.05.25.22275561", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:11:25.774Z", "modified": "2026-08-20T10:11:25.964Z"}, {"entity": "publication", "iuid": "1bdae64c008244cd8ad1d2488fa9e21d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1bdae64c008244cd8ad1d2488fa9e21d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1bdae64c008244cd8ad1d2488fa9e21d"}}, "title": "An online atlas of human plasma metabolite signatures of gut microbiome composition", "authors": [{"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Nielsen", "given": "Nynne", "initials": "N", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Holm", "given": "Jacob Bak", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB"}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-1914-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edbc11d091084a2392a8dfc062f070e8.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2021-12-30", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268179", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:07:54.099Z", "modified": "2026-08-20T10:07:54.434Z"}]}