{"entity": "researcher", "timestamp": "2026-08-28T00:39:18.178Z", "family": "Trofimov", "given": "Alexander", "initials": "A", "orcid": "0000-0001-6745-6035", "affiliations": ["CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.", "CiBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504, Coimbra, Portugal.", "Integrative Brain Function Neurobiology Lab, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, 197022, St. Petersburg, Russia.", "Department of Biology, School of Sciences and Humanities, Nazarbayev University, 010000, Astana, Kazakhstan."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed1b911a20934ca3a3d89d329d251607.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed1b911a20934ca3a3d89d329d251607"}}, "publications": [{"entity": "publication", "iuid": "a63562f8b79e4f968c797d41e9c307b4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a63562f8b79e4f968c797d41e9c307b4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a63562f8b79e4f968c797d41e9c307b4"}}, "title": "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress.", "authors": [{"family": "Rodrigues", "given": "Beatriz", "initials": "B"}, {"family": "Leit\u00e3o", "given": "Ricardo A", "initials": "RA"}, {"family": "Santos", "given": "M\u00f3nica", "initials": "M", "orcid": "0000-0003-3229-8270", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8968fc0a6f94a20ba50b28fc4bebdf8.json"}}, {"family": "Trofimov", "given": "Alexander", "initials": "A", "orcid": "0000-0001-6745-6035", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed1b911a20934ca3a3d89d329d251607.json"}}, {"family": "Silva", "given": "Mariline", "initials": "M"}, {"family": "In\u00e1cio", "given": "\u00c2ngela S", "initials": "\u00c2S"}, {"family": "Abreu", "given": "M\u00f3nica", "initials": "M"}, {"family": "Nobre", "given": "Rui J", "initials": "RJ"}, {"family": "Costa", "given": "J\u00e9ssica", "initials": "J"}, {"family": "Cardoso", "given": "Ana Lu\u00edsa", "initials": "AL"}, {"family": "Milosevic", "given": "Ira", "initials": "I"}, {"family": "Pe\u00e7a", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Oliveiros", "given": "B\u00e1rbara", "initials": "B"}, {"family": "Pereira de Almeida", "given": "Lu\u00eds", "initials": "L"}, {"family": "Pinheiro", "given": "Paulo S", "initials": "PS", "orcid": "0000-0002-9024-1021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8977124563114a24b9aaad40fec269f8.json"}}, {"family": "Carvalho", "given": "Ana Lu\u00edsa", "initials": "AL", "orcid": "0000-0001-8368-6666", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc3043661fca4019b591058727edf354.json"}}], "type": "journal article", "published": "2025-03-00", "journal": {"title": "Mol. Psychiatry", "issn": "1476-5578", "volume": "30", "issue": "3", "pages": "1034-1046", "issn-l": "1359-4184"}, "abstract": "Chronic stress exerts profound negative effects on cognitive and emotional behaviours and is a major risk factor for the development of neuropsychiatric disorders. However, the molecular links between chronic stress and its deleterious effects on neuronal and synaptic function remain elusive. Here, using a combination of in vitro and in vivo approaches, we demonstrate that the upregulation of miR-186-5p triggered by chronic stress may be a key mediator of such changes, leading to synaptic dysfunction. Our results show that the expression levels of miR-186-5p are increased both in the prefrontal cortex (PFC) of mice exposed to chronic stress and in cortical neurons chronically exposed to dexamethasone. Additionally, viral overexpression of miR-186-5p in the PFC of na\u00efve mice induces anxiety- and depressive-like behaviours. The upregulation of miR-186-5p through prolonged glucocorticoid receptor activation in vitro, or in a mouse model of chronic stress, differentially affects glutamatergic and GABAergic synaptic transmission, causing an imbalance in excitation/inhibition that leads to altered neuronal network activity. At glutamatergic synapses, we observed both a reduction in synaptic AMPARs and synaptic transmission, whereas GABAergic synaptic transmission was strengthened. These changes could be rescued in vitro by a miR-186-5p inhibitor. Overall, our results establish a novel molecular link between chronic glucocorticoid receptor activation, the upregulation of miR-186-5p and the synaptic changes induced by chronic stress, that may be amenable to therapeutic intervention.", "doi": "10.1038/s41380-024-02715-1", "pmid": "39237722", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11835755"}, {"db": "pii", "key": "10.1038/s41380-024-02715-1"}], "notes": [], "created": "2026-08-21T11:47:02.149Z", "modified": "2026-08-21T11:47:02.344Z"}]}