{"entity": "researcher", "timestamp": "2026-09-28T18:22:00.156Z", "family": "Ferraz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-0202-2401", "affiliations": ["Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, Box 534, 75121, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed1b02298827447a8b9fb82353bad1fb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed1b02298827447a8b9fb82353bad1fb"}}, "publications": [{"entity": "publication", "iuid": "e5367380f2254965a981ad463926f2a3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e5367380f2254965a981ad463926f2a3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e5367380f2254965a981ad463926f2a3"}}, "title": "Blood Compatibility of Sulfonated Cladophora Nanocellulose Beads.", "authors": [{"family": "Rocha", "given": "Igor", "initials": "I", "orcid": "0000-0003-2546-7224", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e45f21bac8d4f6ba4eda3d92e03bdbd.json"}}, {"family": "Lindh", "given": "Jonas", "initials": "J"}, {"family": "Hong", "given": "Jaan", "initials": "J"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Mihranyan", "given": "Albert", "initials": "A"}, {"family": "Ferraz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-0202-2401", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed1b02298827447a8b9fb82353bad1fb.json"}}], "type": "journal article", "published": "2018-03-07", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "23", "issue": "3", "issn-l": "1420-3049"}, "abstract": "Sulfonated cellulose beads were prepared by oxidation of Cladophora nanocellulose to 2,3-dialdehyde cellulose followed by sulfonation using bisulfite. The physicochemical properties of the sulfonated beads, i.e., high surface area, high degree of oxidation, spherical shape, and the possibility of tailoring the porosity, make them interesting candidates for the development of immunosorbent platforms, including their application in extracorporeal blood treatments. A desired property for materials used in such applications is blood compatibility; therefore in the present work, we investigate the hemocompatibility of the sulfonated cellulose beads using an in vitro whole blood model. Complement system activation (C3a and sC5b-9 levels), coagulation activation (thrombin-antithrombin (TAT) levels) and hemolysis were evaluated after whole blood contact with the sulfonated beads and the results were compared with the values obtained with the unmodified Cladophora nanocellulose. Results showed that neither of the cellulosic materials presented hemolytic activity. A marked decrease in TAT levels was observed after blood contact with the sulfonated beads, compared with Cladophora nanocellulose. However, the chemical modification did not promote an improvement in Cladophora nanocellulose hemocompatibility in terms of complement system activation. Even though the sulfonated beads presented a significant reduction in pro-coagulant activity compared with the unmodified material, further modification strategies need to be investigated to control the complement activation by the cellulosic materials.", "doi": "10.3390/molecules23030601", "pmid": "29518966", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6017088"}, {"db": "pii", "key": "molecules23030601"}], "notes": [], "created": "2026-09-23T10:13:20.016Z", "modified": "2026-09-23T10:51:45.615Z"}, {"entity": "publication", "iuid": "4dff9d22d5b843f882349d3e5c779bff", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4dff9d22d5b843f882349d3e5c779bff.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4dff9d22d5b843f882349d3e5c779bff"}}, "title": "Hemocompatibility of Ca2+ -Crosslinked Nanocellulose Hydrogels: Toward Efficient Management of Hemostasis.", "authors": [{"family": "Basu", "given": "Alex", "initials": "A"}, {"family": "Hong", "given": "Jaan", "initials": "J"}, {"family": "Ferraz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-0202-2401", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed1b02298827447a8b9fb82353bad1fb.json"}}], "type": "journal article", "published": "2017-11-00", "journal": {"title": "Macromol Biosci", "issn": "1616-5195", "volume": "17", "issue": "11", "issn-l": "1616-5187"}, "abstract": "The present work investigates Ca2+ -crosslinked nanofibrillated cellulose hydrogels as potential hemostatic wound dressings by studying core interactions between the materials and a central component of wounds and wound healing-the blood. Hydrogels of wood-derived anionic nanofibrillated cellulose (NFC) and NFC hydrogels that incorporate kaolin or collagen are studied in an in vitro whole blood model and with platelet-free plasma assays. The evaluation of thrombin and factor XIIa formation, platelet reduction, and the release of activated complement system proteins, shows that the NFC hydrogel efficiently triggered blood coagulation, with a rapid onset of clot formation, while displaying basal complement system activation. By using the NFC hydrogel as a carrier of kaolin, the onset of hemostasis is further boosted, while the NFC hydrogel containing collagen exhibits blood activating properties comparable to the anionic NFC hydrogel. The herein studied NFC hydrogels demonstrate great potential for being part of advanced wound healing dressings that can be tuned to target certain wounds (e.g., strongly hemorrhaging ones) or specific phases of the wound healing process for optimal wound management.", "doi": "10.1002/mabi.201700236", "pmid": "28941135", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T09:19:15.320Z", "modified": "2026-09-23T09:19:15.376Z"}]}