{"entity": "researcher", "timestamp": "2026-08-20T20:45:16.913Z", "family": "Cianfanelli", "given": "Valentina", "initials": "V", "orcid": "0000-0002-3857-9463", "affiliations": ["Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.", "Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Ges\u00f9 Children's Hospital, Rome, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecd317d35f4142febdd006e4c19ecd3b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecd317d35f4142febdd006e4c19ecd3b"}}, "publications": [{"entity": "publication", "iuid": "5137acade2f14370b914614b3b1b44fa", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5137acade2f14370b914614b3b1b44fa.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5137acade2f14370b914614b3b1b44fa"}}, "title": "The PP2A-B55\u03b1 phosphatase is a master regulator of mitochondrial degradation and biogenesis.", "authors": [{"family": "Cianfanelli", "given": "Valentina", "initials": "V", "orcid": "0000-0002-3857-9463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecd317d35f4142febdd006e4c19ecd3b.json"}}, {"family": "Nanni", "given": "Monica", "initials": "M", "orcid": "0000-0001-5706-0053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09b0dc7e755640268eb404b8984fe701.json"}}, {"family": "Corr\u00e0", "given": "Samantha", "initials": "S", "orcid": "0000-0003-1985-6194", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34aed5b4b7d14834bcbcd1550714f9ef.json"}}, {"family": "Mauri", "given": "Sofia", "initials": "S", "orcid": "0000-0003-3931-1490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e0ea3075fda4ba18327bc96a9123f69.json"}}, {"family": "Sumpton", "given": "David", "initials": "D", "orcid": "0000-0002-9004-4079", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f3a17d1b74741f8bccfff7c0ad05b19.json"}}, {"family": "Lilla", "given": "Sergio", "initials": "S", "orcid": "0000-0003-3142-7640", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a5956d3819947df8122ec1601025bbc.json"}}, {"family": "De Cegli", "given": "Rossella", "initials": "R", "orcid": "0000-0002-8526-8692", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1269d7def39540659533698e1282ce13.json"}}, {"family": "Bordi", "given": "Matteo", "initials": "M", "orcid": "0000-0001-8207-8546", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c34176b2b1141f6a41d23f49de8e4ec.json"}}, {"family": "Milletti", "given": "Giacomo", "initials": "G", "orcid": "0000-0003-2391-342X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f829170c13433d95819874b6fa3952.json"}}, {"family": "Ferraina", "given": "Caterina", "initials": "C", "orcid": "0000-0002-3770-4437", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb9f5ebe210040f78d03e3bc8503c727.json"}}, {"family": "Hall", "given": "Arnaldur", "initials": "A", "orcid": "0000-0001-6847-4438", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4c8a78056504735b11d15abd86dc46d.json"}}, {"family": "Petraroia", "given": "Michele", "initials": "M", "orcid": "0009-0000-0329-1155", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10cc6330b16e4a338e87c3a38ccb36da.json"}}, {"family": "Clausi", "given": "Valentina", "initials": "V", "orcid": "0009-0008-2662-4774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/027ce4a5d2f745b392ee0a6e92f65b5d.json"}}, {"family": "Giorda", "given": "Ezio", "initials": "E", "orcid": "0000-0002-5875-832X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6005bedf7cd44c678a5e50a999ba06dd.json"}}, {"family": "Scarsella", "given": "Marco", "initials": "M", "orcid": "0000-0002-3386-9664", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8fe29ee7e764f6bb29092e11f52c6f9.json"}}, {"family": "Barbiera", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-2051-2359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c18e2aab6af747439958edfa9be888a7.json"}}, {"family": "Cadeddu", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1841-8395", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c209292faee4904bda06ce017551fd8.json"}}, {"family": "Colasanti", "given": "Marco", "initials": "M", "orcid": "0000-0002-5752-4943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/479c78cbd64a455a9b7f5cbedd475fa0.json"}}, {"family": "Persichini", "given": "Tiziana", "initials": "T", "orcid": "0000-0001-8291-6706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d80e8c50c4f45b8b13eda46cbbc3067.json"}}, {"family": "Maeda", "given": "Kenji", "initials": "K", "orcid": "0000-0002-9080-5691", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dc9c0792c6c44e29090a2683a73f884.json"}}, {"family": "Maya-Mendoza", "given": "Apolinar", "initials": "A", "orcid": "0000-0001-7452-9896", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8120d9952114478b9909d9906e0dd543.json"}}, {"family": "Bartek", "given": "Jiri", "initials": "J", "orcid": "0000-0003-2013-7525", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/288939950c0c4c6393d35c84e5128b5f.json"}}, {"family": "Di Malta", "given": "Chiara", "initials": "C", "orcid": "0000-0001-6524-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bef2e1eff2cf49f6ba6da220d8e76d2c.json"}}, {"family": "Locatelli", "given": "Franco", "initials": "F", "orcid": "0000-0002-7976-3654", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2687cc638c754f099e9a76deec1d8911.json"}}, {"family": "Zanivan", "given": "Sara", "initials": "S"}, {"family": "Ismail", "given": "Shehab", "initials": "S", "orcid": "0000-0002-4150-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1587edc23d6043eb8c3be75259ef47e2.json"}}, {"family": "Ziviani", "given": "Elena", "initials": "E"}, {"family": "Cecconi", "given": "Francesco", "initials": "F", "orcid": "0000-0002-5614-4359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1736eeb3ba3d4b0f80058b507487c5e1.json"}}], "type": "journal article", "published": "2025-10-03", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "11", "issue": "40", "pages": "eadw7376", "issn-l": "2375-2548"}, "abstract": "Mitochondrial homeostasis relies on a tight balance between mitochondrial biogenesis and degradation. Although mitophagy is one of the main pathways involved in the clearance of damaged or old mitochondria, its coordination with mitochondrial biogenesis is poorly characterized. Here, by unbiased approaches including last-generation liquid chromatography coupled to mass spectrometry and transcriptomics, we identify the protein phosphatase PP2A-B55\u03b1/PPP2R2A as a Parkin-dependent regulator of mitochondrial number. Upon mitochondrial damage, PP2A-B55\u03b1 determines the amplitude of mitophagy induction and execution by regulating both early and late mitophagy events. A few minutes after the insult, ULK1 is released from the inhibitory regulation of PP2A-B55\u03b1, whereas 2 to 4 hours later, PP2A-B55\u03b1 promotes the nuclear translocation of TFEB, the master regulator of autophagy and lysosome genes, to support mitophagy execution. Moreover, PP2A-B55\u03b1 controls a transcriptional program of mitochondrial biogenesis by stabilizing the Parkin substrate and PGC-1\u03b1 inhibitor PARIS. PP2A-B55\u03b1 targeting rescues neurodegenerative phenotypes in a fly model of Parkinson's disease, thus suggesting potential therapeutic application.", "doi": "10.1126/sciadv.adw7376", "pmid": "41042873", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12494018"}], "notes": [], "created": "2026-08-20T11:59:09.713Z", "modified": "2026-08-20T11:59:10.839Z"}, {"entity": "publication", "iuid": "b7277dd6ce53475d840bb9e1376bb4fd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b7277dd6ce53475d840bb9e1376bb4fd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b7277dd6ce53475d840bb9e1376bb4fd"}}, "title": "AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.", "authors": [{"family": "Maiani", "given": "Emiliano", "initials": "E", "orcid": "0000-0003-1432-5394", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28a7ce582c73429f8723c52f53c39136.json"}}, {"family": "Milletti", "given": "Giacomo", "initials": "G", "orcid": "0000-0003-2391-342X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f829170c13433d95819874b6fa3952.json"}}, {"family": "Nazio", "given": "Francesca", "initials": "F"}, {"family": "Holdgaard", "given": "S\u00f8s Gr\u00f8nb\u00e6k", "initials": "SG"}, {"family": "Bartkova", "given": "Jirina", "initials": "J"}, {"family": "Rizza", "given": "Salvatore", "initials": "S", "orcid": "0000-0001-7335-4684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6105a9f41af4c54bdf0b74c11a5701f.json"}}, {"family": "Cianfanelli", "given": "Valentina", "initials": "V", "orcid": "0000-0002-3857-9463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecd317d35f4142febdd006e4c19ecd3b.json"}}, {"family": "Lorente", "given": "Mar", "initials": "M"}, {"family": "Simoneschi", "given": "Daniele", "initials": "D", "orcid": "0000-0003-0448-4295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ef930f13dc34b09893d417f99a1822c.json"}}, {"family": "Di Marco", "given": "Miriam", "initials": "M"}, {"family": "D'Acunzo", "given": "Pasquale", "initials": "P", "orcid": "0000-0001-7237-0076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae134a21c0f44416a8f7825d3985d465.json"}}, {"family": "Di Leo", "given": "Luca", "initials": "L", "orcid": "0000-0002-2419-2196", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b38f503dd3d34de885137408e2b10daf.json"}}, {"family": "Rasmussen", "given": "Rikke", "initials": "R"}, {"family": "Montagna", "given": "Costanza", "initials": "C"}, {"family": "Raciti", "given": "Marilena", "initials": "M"}, {"family": "De Stefanis", "given": "Cristiano", "initials": "C"}, {"family": "Gabicagogeascoa", "given": "Estibaliz", "initials": "E"}, {"family": "Rona", "given": "Gergely", "initials": "G"}, {"family": "Salvador", "given": "N\u00e9lida", "initials": "N"}, {"family": "Pupo", "given": "Emanuela", "initials": "E"}, {"family": "Merchut-Maya", "given": "Joanna Maria", "initials": "JM"}, {"family": "Daniel", "given": "Colin J", "initials": "CJ"}, {"family": "Carinci", "given": "Marianna", "initials": "M"}, {"family": "Cesarini", "given": "Valeriana", "initials": "V"}, {"family": "O'sullivan", "given": "Alfie", "initials": "A"}, {"family": "Jeong", "given": "Yeon-Tae", "initials": "YT"}, {"family": "Bordi", "given": "Matteo", "initials": "M", "orcid": "0000-0001-8207-8546", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c34176b2b1141f6a41d23f49de8e4ec.json"}}, {"family": "Russo", "given": "Francesco", "initials": "F"}, {"family": "Campello", "given": "Silvia", "initials": "S", "orcid": "0000-0003-0536-2484", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2efe505b1c654d21a2e1bc7747b8d739.json"}}, {"family": "Gallo", "given": "Angela", "initials": "A"}, {"family": "Filomeni", "given": "Giuseppe", "initials": "G", "orcid": "0000-0002-2719-1412", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d3fdc6c498f4104a43fa2d2198ef484.json"}}, {"family": "Lanzetti", "given": "Letizia", "initials": "L", "orcid": "0000-0001-7541-5524", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2da7f657203439d8bc75b048c181dd2.json"}}, {"family": "Sears", "given": "Rosalie C", "initials": "RC", "orcid": "0000-0003-1558-2413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6cc5e16675434a58b04b0db6ad618167.json"}}, {"family": "Hamerlik", "given": "Petra", "initials": "P"}, {"family": "Bartolazzi", "given": "Armando", "initials": "A", "orcid": "0000-0001-7820-5127", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d5a218ebfcd45b4aae83562b6801f33.json"}}, {"family": "Hynds", "given": "Robert E", "initials": "RE", "orcid": "0000-0002-2170-8791", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d363c63598224cb0bd24dffc46d0d3eb.json"}}, {"family": "Pearce", "given": "David R", "initials": "DR", "orcid": "0000-0001-8443-2924", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e102ef6912747fba625f94fb0d8b774.json"}}, {"family": "Swanton", "given": "Charles", "initials": "C", "orcid": "0000-0002-4299-3018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e624db9004da4812a607b34b20cea0e7.json"}}, {"family": "Pagano", "given": "Michele", "initials": "M"}, {"family": "Velasco", "given": "Guillermo", "initials": "G", "orcid": "0000-0002-1994-2386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bc733f7578d48739bceff94fbc156cb.json"}}, {"family": "Papaleo", "given": "Elena", "initials": "E"}, {"family": "De Zio", "given": "Daniela", "initials": "D", "orcid": "0000-0002-9454-402X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9493b5e7aab54818b2142490af5ea7b9.json"}}, {"family": "Maya-Mendoza", "given": "Apolinar", "initials": "A", "orcid": "0000-0001-7452-9896", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8120d9952114478b9909d9906e0dd543.json"}}, {"family": "Locatelli", "given": "Franco", "initials": "F"}, {"family": "Bartek", "given": "Jiri", "initials": "J", "orcid": "0000-0003-2013-7525", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/288939950c0c4c6393d35c84e5128b5f.json"}}, {"family": "Cecconi", "given": "Francesco", "initials": "F", "orcid": "0000-0002-5614-4359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1736eeb3ba3d4b0f80058b507487c5e1.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "592", "issue": "7856", "pages": "799-803", "issn-l": "0028-0836"}, "abstract": "Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance. The key cell-fate decision to replicate the genome is controlled by two major signalling pathways that act in parallel-the MYC pathway and the cyclin D-cyclin-dependent kinase (CDK)-retinoblastoma protein (RB) pathway1,2. Both MYC and the cyclin D-CDK-RB axis are commonly deregulated in cancer, and this is associated with increased genomic instability. The autophagic tumour-suppressor protein AMBRA1 has been linked to the control of cell proliferation, but the underlying molecular mechanisms remain poorly understood. Here we show that AMBRA1 is an upstream master regulator of the transition from G1 to S phase and thereby prevents replication stress. Using a combination of cell and molecular approaches and in vivo models, we reveal that AMBRA1 regulates the abundance of D-type cyclins by mediating their degradation. Furthermore, by controlling the transition from G1 to S phase, AMBRA1 helps to maintain genomic integrity during DNA replication, which counteracts developmental abnormalities and tumour growth. Finally, we identify the CHK1 kinase as a potential therapeutic target in AMBRA1-deficient tumours. These results advance our understanding of the control of replication-phase entry and genomic integrity, and identify the AMBRA1-cyclin D pathway as a crucial cell-cycle-regulatory mechanism that is deeply interconnected with genomic stability in embryonic development and tumorigenesis.", "doi": "10.1038/s41586-021-03422-5", "pmid": "33854232", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1776644"}, {"db": "pmc", "key": "PMC8864551"}, {"db": "pii", "key": "10.1038/s41586-021-03422-5"}], "notes": [], "created": "2026-08-20T08:56:26.998Z", "modified": "2026-08-20T08:57:56.476Z"}]}