{"entity": "researcher", "timestamp": "2026-03-09T08:25:55.438Z", "family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "affiliations": ["Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72"}}, "publications": [{"entity": "publication", "iuid": "ec2cc1f2f82349ebad78c1e7c3f76984", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ec2cc1f2f82349ebad78c1e7c3f76984.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ec2cc1f2f82349ebad78c1e7c3f76984"}}, "title": "Next generation pan-cancer blood proteome profiling using proximity extension assay.", "authors": [{"family": "\u00c1lvez", "given": "Mar\u00eda Bueno", "initials": "MB", "orcid": "0000-0002-2669-7796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7d09e4780a445b9b432d494c76d07e8.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "von Feilitzen", "given": "Kalle", "initials": "K", "orcid": "0000-0002-0257-7554", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4c4545bd2324b7d9b6696dab5bcb7dd.json"}}, {"family": "Zwahlen", "given": "Martin", "initials": "M", "orcid": "0000-0002-0064-4776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/456805fa3f4f47328f3923b78bf66996.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}, {"family": "Edqvist", "given": "Per-Henrik", "initials": "PH", "orcid": "0000-0002-8330-0134", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5219527c2dc6480da474f3c47dff9318.json"}}, {"family": "Sj\u00f6blom", "given": "Tobias", "initials": "T", "orcid": "0000-0001-6668-4140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/851b95a56b3244fb9bc7cec8294e7ae7.json"}}, {"family": "Lundin", "given": "Emma", "initials": "E", "orcid": "0009-0000-7711-1962", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c300121409e64e4c9a99f59d8b2a07c1.json"}}, {"family": "Rameika", "given": "Natallia", "initials": "N", "orcid": "0000-0002-7835-4357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9ea2e7b3c3f4df8aab2f25ac4f9923b.json"}}, {"family": "Enblad", "given": "Gunilla", "initials": "G", "orcid": "0000-0002-0594-724X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a285fb437854e2c998356b1a3124416.json"}}, {"family": "Lindman", "given": "Henrik", "initials": "H"}, {"family": "H\u00f6glund", "given": "Martin", "initials": "M", "orcid": "0000-0003-2468-0226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b04dde8160944595a255121a2571d2da.json"}}, {"family": "Hesselager", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0001-9613-1344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84c0500c4312423ca21366265e4aa4dc.json"}}, {"family": "St\u00e5lberg", "given": "Karin", "initials": "K", "orcid": "0000-0001-5527-8796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ca801fe1aba4d04a06eaf9f6e3407dd.json"}}, {"family": "Enblad", "given": "Malin", "initials": "M", "orcid": "0000-0001-5900-0900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd2f8ad89196420584d0f79ad24575d3.json"}}, {"family": "Simonson", "given": "Oscar E", "initials": "OE", "orcid": "0000-0002-3552-5558", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f721cc39cb13464b964a10eba1045a04.json"}}, {"family": "H\u00e4ggman", "given": "Michael", "initials": "M"}, {"family": "Axelsson", "given": "Tomas", "initials": "T"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M", "orcid": "0000-0002-7858-8233", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a08650cb00404b6dba35959f3cb0a53c.json"}}, {"family": "Nordlund", "given": "Jessica", "initials": "J", "orcid": "0000-0001-8699-9959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27ee07e408e24eefa23105dcc6aa252b.json"}}, {"family": "Zhong", "given": "Wen", "initials": "W", "orcid": "0000-0002-7422-6104", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6ffb1140aaa42c5ac63fe76653fc63b.json"}}, {"family": "Karlsson", "given": "Max", "initials": "M", "orcid": "0000-0002-7000-4416", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b93284f942e44f1086616357d77267c3.json"}}, {"family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}}, {"family": "Ponten", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0703-3940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f5294424542413c9ba4432c839c2b63.json"}}, {"family": "Fagerberg", "given": "Linn", "initials": "L", "orcid": "0000-0003-0198-7137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abbbf8193d5a4376a5c726768d039439.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}], "type": "journal article", "published": "2023-07-18", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "4308", "issn-l": "2041-1723"}, "abstract": "A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein profiling to explore the proteome signature in blood across patients representing many of the major cancer types. Plasma profiles of 1463 proteins from more than 1400 cancer patients are measured in minute amounts of blood collected at the time of diagnosis and before treatment. An open access Disease Blood Atlas resource allows the exploration of the individual protein profiles in blood collected from the individual cancer patients. We also present studies in which classification models based on machine learning have been used for the identification of a set of proteins associated with each of the analyzed cancers. The implication for cancer precision medicine of next generation plasma profiling is discussed.", "doi": "10.1038/s41467-023-39765-y", "pmid": "37463882", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10354027"}, {"db": "pii", "key": "10.1038/s41467-023-39765-y"}], "notes": [], "created": "2023-12-04T14:49:43.596Z", "modified": "2023-12-04T14:49:44.157Z"}, {"entity": "publication", "iuid": "61e8816e8d6e421dbf1ee3ee3e0fb89c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/61e8816e8d6e421dbf1ee3ee3e0fb89c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/61e8816e8d6e421dbf1ee3ee3e0fb89c"}}, "title": "The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.", "authors": [{"family": "Winkler", "given": "Thomas W", "initials": "TW"}, {"family": "Justice", "given": "Anne E", "initials": "AE"}, {"family": "Graff", "given": "Mariaelisa", "initials": "M"}, {"family": "Barata", "given": "Llilda", "initials": "L"}, {"family": "Feitosa", "given": "Mary F", "initials": "MF"}, {"family": "Chu", "given": "Su", "initials": "S"}, {"family": "Czajkowski", "given": "Jacek", "initials": "J"}, {"family": "Esko", "given": "T\u00f5nu", "initials": "T"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}, {"family": "Kilpel\u00e4inen", "given": "Tuomas O", "initials": "TO"}, {"family": "Lu", "given": "Yingchang", "initials": "Y"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "Mihailov", "given": "Evelin", "initials": "E"}, {"family": "Pers", "given": "Tune H", "initials": "TH"}, {"family": "R\u00fceger", "given": "Sina", "initials": "S"}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "Ehret", "given": "Georg B", "initials": "GB", "orcid": "0000-0002-5730-0675", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1fe0233af4614b8b870be7bb90772368.json"}}, {"family": "Ferreira", "given": "Teresa", "initials": "T"}, {"family": "Heard-Costa", "given": "Nancy L", "initials": "NL"}, {"family": "Karjalainen", "given": "Juha", "initials": "J"}, {"family": "Lagou", "given": "Vasiliki", "initials": "V"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Neinast", "given": "Michael D", "initials": "MD"}, {"family": "Prokopenko", "given": "Inga", "initials": "I"}, {"family": "Simino", "given": "Jeannette", "initials": "J"}, {"family": "Teslovich", "given": "Tanya M", "initials": "TM"}, {"family": "Jansen", "given": "Rick", "initials": "R", "orcid": "0000-0002-3333-6737", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22e8fe75ac5c4fb6b92ab7738ea96339.json"}}, {"family": "Westra", "given": "Harm-Jan", "initials": "HJ", "orcid": "0000-0001-7038-567X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdcf5e246bc341d2ae66f80b783a84ef.json"}}, {"family": "White", "given": "Charles C", "initials": "CC"}, {"family": "Absher", "given": "Devin", "initials": "D"}, {"family": "Ahluwalia", "given": "Tarunveer S", "initials": "TS"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Albrecht", "given": "Eva", "initials": "E"}, {"family": "Alves", "given": "Alexessander Couto", "initials": "AC"}, {"family": "Bragg-Gresham", "given": "Jennifer L", "initials": "JL"}, {"family": "de Craen", "given": "Anton J M", "initials": "AJ"}, {"family": "Bis", "given": "Joshua C", "initials": "JC", "orcid": "0000-0002-3409-1110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de8dd43c6fe64ebbaf718500e4fef3d9.json"}}, {"family": "Bonnefond", "given": "Am\u00e9lie", "initials": "A"}, {"family": "Boucher", "given": "Gabrielle", "initials": "G"}, {"family": "Cadby", "given": "Gemma", "initials": "G"}, {"family": "Cheng", "given": "Yu-Ching", "initials": "YC"}, {"family": "Chiang", "given": "Charleston W K", "initials": "CW"}, {"family": "Delgado", "given": "Graciela", "initials": "G"}, {"family": "Demirkan", "given": "Ayse", "initials": "A"}, {"family": "Dueker", "given": "Nicole", "initials": "N"}, {"family": "Eklund", "given": "Niina", "initials": "N"}, {"family": "Eiriksdottir", "given": "Gudny", "initials": "G"}, {"family": "Eriksson", "given": "Joel", "initials": "J"}, {"family": "Feenstra", "given": "Bjarke", "initials": "B"}, {"family": "Fischer", "given": "Krista", "initials": "K"}, {"family": "Frau", "given": "Francesca", "initials": "F"}, {"family": "Galesloot", "given": "Tessel E", "initials": "TE"}, {"family": "Geller", "given": "Frank", "initials": "F"}, {"family": "Goel", "given": "Anuj", "initials": "A"}, {"family": "Gorski", "given": "Mathias", "initials": "M"}, {"family": "Grammer", "given": "Tanja B", "initials": "TB"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S"}, {"family": "Haitjema", "given": "Saskia", "initials": "S"}, {"family": "Hottenga", "given": "Jouke-Jan", "initials": "JJ"}, {"family": "Huffman", "given": "Jennifer E", "initials": "JE"}, {"family": "Jackson", "given": "Anne U", "initials": "AU", "orcid": "0000-0002-9672-2547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d63df156aa9247d3a547cdcb2c86bff5.json"}}, {"family": "Jacobs", "given": "Kevin B", "initials": "KB"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0003-0548-5943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6266bc748e1345a49138a7604f817deb.json"}}, {"family": "Kaakinen", "given": "Marika", "initials": "M"}, {"family": "Kleber", "given": "Marcus E", "initials": "ME", "orcid": "0000-0003-0663-7275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22bc3077d1244542bcd6222f70dd7c96.json"}}, {"family": "Lahti", "given": "Jari", "initials": "J"}, {"family": "Mateo Leach", "given": "Irene", "initials": "I"}, {"family": "Lehne", "given": "Benjamin", "initials": "B"}, {"family": "Liu", "given": "Youfang", "initials": "Y"}, {"family": "Lo", "given": "Ken Sin", "initials": "KS"}, {"family": "Lorentzon", "given": "Mattias", "initials": "M"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Madden", "given": "Pamela A F", "initials": "PA"}, {"family": "Mangino", "given": "Massimo", "initials": "M", "orcid": "0000-0002-2167-7470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1c90171562c487392b4257d272d3c17.json"}}, {"family": "McKnight", "given": "Barbara", "initials": "B"}, {"family": "Medina-Gomez", "given": "Carolina", "initials": "C"}, {"family": "Monda", "given": "Keri L", "initials": "KL"}, {"family": "Montasser", "given": "May E", "initials": "ME"}, {"family": "M\u00fcller", "given": "Gabriele", "initials": "G"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M"}, {"family": "Nolte", "given": "Ilja M", "initials": "IM", "orcid": "0000-0001-5047-4077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f5412b9a3a24cd9886c668836025c1b.json"}}, {"family": "Panoutsopoulou", "given": "Kalliope", "initials": "K"}, {"family": "Pascoe", "given": "Laura", "initials": "L"}, {"family": "Paternoster", "given": "Lavinia", "initials": "L"}, {"family": "Rayner", "given": "Nigel W", "initials": "NW"}, {"family": "Renstr\u00f6m", "given": "Frida", "initials": "F"}, {"family": "Rizzi", "given": "Federica", "initials": "F"}, {"family": "Rose", "given": "Lynda M", "initials": "LM"}, {"family": "Ryan", "given": "Kathy A", "initials": "KA"}, {"family": "Salo", "given": "Perttu", "initials": "P"}, {"family": "Sanna", "given": "Serena", "initials": "S", "orcid": "0000-0002-3768-1749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34dda39900cb4971bdbeef61f721cab7.json"}}, {"family": "Scharnagl", "given": "Hubert", "initials": "H"}, {"family": "Shi", "given": "Jianxin", "initials": "J"}, {"family": "Smith", "given": "Albert Vernon", "initials": "AV", "orcid": "0000-0003-1942-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51752e0d35a74befa66a65b95ceaad38.json"}}, {"family": "Southam", "given": "Lorraine", "initials": "L"}, {"family": "Stan\u010d\u00e1kov\u00e1", "given": "Alena", "initials": "A"}, {"family": "Steinthorsdottir", "given": "Valgerdur", "initials": "V"}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ", "orcid": "0000-0001-8506-3585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cccd06a2fb54f769c5710c8758f2ebe.json"}}, {"family": "Sung", "given": "Yun Ju", "initials": "YJ"}, {"family": "Tachmazidou", "given": "Ioanna", "initials": "I"}, {"family": "Tanaka", "given": "Toshiko", "initials": "T"}, {"family": "Thorleifsson", "given": "Gudmar", "initials": "G", "orcid": "0000-0003-4623-9087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3460ce8189d243829543bd5919c42588.json"}}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "Pervjakova", "given": "Natalia", "initials": "N"}, {"family": "Tyrer", "given": "Jonathan P", "initials": "JP"}, {"family": "Vandenput", "given": "Liesbeth", "initials": "L"}, {"family": "van der Laan", "given": "Sander W", "initials": "SW"}, {"family": "van der Velde", "given": "Nathalie", "initials": "N"}, {"family": "van Setten", "given": "Jessica", "initials": "J"}, {"family": "van Vliet-Ostaptchouk", "given": "Jana V", "initials": "JV"}, {"family": "Verweij", "given": "Niek", "initials": "N"}, {"family": "Vlachopoulou", "given": "Efthymia", "initials": "E"}, {"family": "Waite", "given": "Lindsay L", "initials": "LL"}, {"family": "Wang", "given": "Sophie R", "initials": "SR"}, {"family": "Wang", "given": "Zhaoming", "initials": "Z"}, {"family": "Wild", "given": "Sarah H", "initials": "SH"}, {"family": "Willenborg", "given": "Christina", "initials": "C"}, {"family": "Wilson", "given": "James F", "initials": "JF"}, {"family": "Wong", "given": "Andrew", "initials": "A"}, {"family": "Yang", "given": "Jian", "initials": "J", "orcid": "0000-0002-4497-9615", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/813a309f6b5c46ff9bff0ac129512c48.json"}}, {"family": "Yengo", "given": "Lo\u00efc", "initials": "L"}, {"family": "Yerges-Armstrong", "given": "Laura M", "initials": "LM"}, {"family": "Yu", "given": "Lei", "initials": "L", "orcid": "0000-0001-6802-7494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be8d88789ed743178f16202e95c73023.json"}}, {"family": "Zhang", "given": "Weihua", "initials": "W"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Andersson", "given": "Ehm A", "initials": "EA"}, {"family": "Bakker", "given": "Stephan J L", "initials": "SJ"}, {"family": "Baldassarre", "given": "Damiano", "initials": "D", "orcid": "0000-0002-2766-8882", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8b84ab3a8e94c5f9f9668e5550f6ace.json"}}, {"family": "Banasik", "given": "Karina", "initials": "K"}, {"family": "Barcella", "given": "Matteo", "initials": "M"}, {"family": "Barlassina", "given": "Cristina", "initials": "C"}, {"family": "Bellis", "given": "Claire", "initials": "C"}, {"family": "Benaglio", "given": "Paola", "initials": "P"}, {"family": "Blangero", "given": "John", "initials": "J"}, {"family": "Bl\u00fcher", "given": "Matthias", "initials": "M", "orcid": "0000-0003-0208-2065", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/587f009a96714fa3910730cf316b5031.json"}}, {"family": "Bonnet", "given": "Fabrice", "initials": "F"}, {"family": "Bonnycastle", "given": "Lori L", "initials": "LL"}, {"family": "Boyd", "given": "Heather A", "initials": "HA"}, {"family": "Bruinenberg", "given": "Marcel", "initials": "M"}, {"family": "Buchman", "given": "Aron S", "initials": "AS"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Chen", "given": "Yii-Der Ida", "initials": "YD"}, {"family": "Chines", "given": "Peter S", "initials": "PS"}, {"family": "Claudi-Boehm", "given": "Simone", "initials": "S"}, {"family": "Cole", "given": "John", "initials": "J"}, {"family": "Collins", "given": "Francis S", "initials": "FS"}, {"family": "de Geus", "given": "Eco J C", "initials": "EJ"}, {"family": "de Groot", "given": "Lisette C P G M", "initials": "LC"}, {"family": "Dimitriou", "given": "Maria", "initials": "M", "orcid": "0000-0001-8362-2099", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/96daf7ad302d49ca938bb2d6043dda28.json"}}, {"family": "Duan", "given": "Jubao", "initials": "J"}, {"family": "Enroth", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5056-9137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae9be8ef3b1145239a4e0231e2a148cd.json"}}, {"family": "Eury", "given": "Elodie", "initials": "E"}, {"family": "Farmaki", "given": "Aliki-Eleni", "initials": "AE"}, {"family": "Forouhi", "given": "Nita G", "initials": "NG"}, {"family": "Friedrich", "given": "Nele", "initials": "N"}, {"family": "Gejman", "given": "Pablo V", "initials": "PV"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}, {"family": "Glorioso", "given": "Nicola", "initials": "N"}, {"family": "Go", "given": "Alan S", "initials": "AS"}, {"family": "Gottesman", "given": "Omri", "initials": "O"}, {"family": "Gr\u00e4\u00dfler", "given": "J\u00fcrgen", "initials": "J"}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Grarup", "given": "Niels", "initials": "N"}, {"family": "Gu", "given": "Yu-Mei", "initials": "YM"}, {"family": "Broer", "given": "Linda", "initials": "L"}, {"family": "Ham", "given": "Annelies C", "initials": "AC"}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Harris", "given": "Tamara B", "initials": "TB"}, {"family": "Hartman", "given": "Catharina A", "initials": "CA"}, {"family": "Hassinen", "given": "Maija", "initials": "M"}, {"family": "Hastie", "given": "Nicholas", "initials": "N"}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT"}, {"family": "Heath", "given": "Andrew C", "initials": "AC"}, {"family": "Henders", "given": "Anjali K", "initials": "AK"}, {"family": "Hernandez", "given": "Dena", "initials": "D"}, {"family": "Hillege", "given": "Hans", "initials": "H"}, {"family": "Holmen", "given": "Oddgeir", "initials": "O"}, {"family": "Hovingh", "given": "Kees G", "initials": "KG"}, {"family": "Hui", "given": "Jennie", "initials": "J"}, {"family": "Husemoen", "given": "Lise L", "initials": "LL"}, {"family": "Hutri-K\u00e4h\u00f6nen", "given": "Nina", "initials": "N"}, {"family": "Hysi", "given": "Pirro G", "initials": "PG"}, {"family": "Illig", "given": "Thomas", "initials": "T"}, {"family": "De Jager", "given": "Philip L", "initials": "PL"}, {"family": "Jalilzadeh", "given": "Shapour", "initials": "S"}, {"family": "J\u00f8rgensen", "given": "Torben", "initials": "T"}, {"family": "Jukema", "given": "J Wouter", "initials": "JW"}, {"family": "Juonala", "given": "Markus", "initials": "M"}, {"family": "Kanoni", "given": "Stavroula", "initials": "S"}, {"family": "Karaleftheri", "given": "Maria", "initials": "M"}, {"family": "Khaw", "given": "Kay Tee", "initials": "KT"}, {"family": "Kinnunen", "given": "Leena", "initials": "L"}, {"family": "Kittner", "given": "Steven J", "initials": "SJ"}, {"family": "Koenig", "given": "Wolfgang", "initials": "W"}, {"family": "Kolcic", "given": "Ivana", "initials": "I"}, {"family": "Kovacs", "given": "Peter", "initials": "P"}, {"family": "Krarup", "given": "Nikolaj T", "initials": "NT"}, {"family": "Kratzer", "given": "Wolfgang", "initials": "W"}, {"family": "Kr\u00fcger", "given": "Janine", "initials": "J"}, {"family": "Kuh", "given": "Diana", "initials": "D"}, {"family": "Kumari", "given": "Meena", "initials": "M"}, {"family": "Kyriakou", "given": "Theodosios", "initials": "T"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Lannfelt", "given": "Lars", "initials": "L"}, {"family": "Lanzani", "given": "Chiara", "initials": "C"}, {"family": "Lotay", "given": "Vaneet", "initials": "V"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Leander", "given": "Karin", "initials": "K"}, {"family": "Lindstr\u00f6m", "given": "Jaana", "initials": "J"}, {"family": "Linneberg", "given": "Allan", "initials": "A"}, {"family": "Liu", "given": "Yan-Ping", "initials": "YP"}, {"family": "Lobbens", "given": "St\u00e9phane", "initials": "S"}, {"family": "Luben", "given": "Robert", "initials": "R"}, {"family": "Lyssenko", "given": "Valeriya", "initials": "V"}, {"family": "M\u00e4nnist\u00f6", "given": "Satu", "initials": "S"}, {"family": "Magnusson", "given": "Patrik K", "initials": "PK"}, {"family": "McArdle", "given": "Wendy L", "initials": "WL"}, {"family": "Menni", "given": "Cristina", "initials": "C"}, {"family": "Merger", "given": "Sigrun", "initials": "S"}, {"family": "Milani", "given": "Lili", "initials": "L"}, {"family": "Montgomery", "given": "Grant W", "initials": "GW"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Narisu", "given": "Narisu", "initials": "N"}, {"family": "Nelis", "given": "Mari", "initials": "M"}, {"family": "Ong", "given": "Ken K", "initials": "KK"}, {"family": "Palotie", "given": "Aarno", "initials": "A"}, {"family": "P\u00e9russe", "given": "Louis", "initials": "L"}, {"family": "Pichler", "given": "Irene", "initials": "I"}, {"family": "Pilia", "given": "Maria G", "initials": "MG"}, {"family": "Pouta", "given": "Anneli", "initials": "A"}, {"family": "Rheinberger", "given": "Myriam", "initials": "M"}, {"family": "Ribel-Madsen", "given": "Rasmus", "initials": "R"}, {"family": "Richards", "given": "Marcus", "initials": "M"}, {"family": "Rice", "given": "Kenneth M", "initials": "KM"}, {"family": "Rice", "given": "Treva K", "initials": "TK"}, {"family": "Rivolta", "given": "Carlo", "initials": "C"}, {"family": "Salomaa", "given": "Veikko", "initials": "V"}, {"family": "Sanders", "given": "Alan R", "initials": "AR"}, {"family": "Sarzynski", "given": "Mark A", "initials": "MA"}, {"family": "Scholtens", "given": "Salome", "initials": "S"}, {"family": "Scott", "given": "Robert A", "initials": "RA"}, {"family": "Scott", "given": "William R", "initials": "WR"}, {"family": "Sebert", "given": "Sylvain", "initials": "S"}, {"family": "Sengupta", "given": "Sebanti", "initials": "S"}, {"family": "Sennblad", "given": "Bengt", "initials": "B"}, {"family": "Seufferlein", "given": "Thomas", "initials": "T"}, {"family": "Silveira", "given": "Angela", "initials": "A"}, {"family": "Slagboom", "given": "P Eline", "initials": "PE"}, {"family": "Smit", "given": "Jan H", "initials": "JH"}, {"family": "Spars\u00f8", "given": "Thomas H", "initials": "TH"}, {"family": "Stirrups", "given": "Kathleen", "initials": "K", "orcid": "0000-0002-6823-3252", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ca7e7404bd44d9582885e0ddf3ffa95.json"}}, {"family": "Stolk", "given": "Ronald P", "initials": "RP"}, {"family": "Stringham", "given": "Heather M", "initials": "HM"}, {"family": "Swertz", "given": "Morris A", "initials": "MA"}, {"family": "Swift", "given": "Amy J", "initials": "AJ"}, {"family": "Syv\u00e4nen", "given": "Ann-Christine", "initials": "AC"}, {"family": "Tan", "given": "Sian-Tsung", "initials": "ST"}, {"family": "Thorand", "given": "Barbara", "initials": "B"}, {"family": "T\u00f6njes", "given": "Anke", "initials": "A"}, {"family": "Tremblay", "given": "Angelo", "initials": "A"}, {"family": "Tsafantakis", "given": "Emmanouil", "initials": "E"}, {"family": "van der Most", "given": "Peter J", "initials": "PJ"}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U"}, {"family": "Vohl", "given": "Marie-Claude", "initials": "MC"}, {"family": "Vonk", "given": "Judith M", "initials": "JM"}, {"family": "Waldenberger", "given": "Melanie", "initials": "M"}, {"family": "Walker", "given": "Ryan W", "initials": "RW"}, {"family": "Wennauer", "given": "Roman", "initials": "R"}, {"family": "Wid\u00e9n", "given": "Elisabeth", "initials": "E"}, {"family": "Willemsen", "given": "Gonneke", "initials": "G"}, {"family": "Wilsgaard", "given": "Tom", "initials": "T"}, {"family": "Wright", "given": "Alan F", "initials": "AF"}, {"family": "Zillikens", "given": "M Carola", "initials": "MC"}, {"family": "van Dijk", "given": "Suzanne C", "initials": "SC"}, {"family": "van Schoor", "given": "Natasja M", "initials": "NM"}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW", "orcid": "0000-0002-1692-8669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/181a8a467ca54344b574d248cc98f1d3.json"}}, {"family": "de Bakker", "given": "Paul I W", "initials": "PI"}, {"family": "Beckmann", "given": "Jacques S", "initials": "JS"}, {"family": "Beilby", "given": "John", "initials": "J"}, {"family": "Bennett", "given": "David A", "initials": "DA"}, {"family": "Bergman", "given": "Richard N", "initials": "RN"}, {"family": "Bergmann", "given": "Sven", "initials": "S"}, {"family": "B\u00f6ger", "given": "Carsten A", "initials": "CA"}, {"family": "Boehm", "given": "Bernhard O", "initials": "BO"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Boomsma", "given": "Dorret I", "initials": "DI"}, {"family": "Bornstein", "given": "Stefan R", "initials": "SR"}, {"family": "Bottinger", "given": "Erwin P", "initials": "EP"}, {"family": "Bouchard", "given": "Claude", "initials": "C"}, {"family": "Chambers", "given": "John C", "initials": "JC"}, {"family": "Chanock", "given": "Stephen J", "initials": "SJ"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "Cucca", "given": "Francesco", "initials": "F"}, {"family": "Cusi", "given": "Daniele", "initials": "D"}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Erdmann", "given": "Jeanette", "initials": "J"}, {"family": "Eriksson", "given": "Johan G", "initials": "JG"}, {"family": "Evans", "given": "Denis A", "initials": "DA"}, {"family": "de Faire", "given": "Ulf", "initials": "U"}, {"family": "Farrall", "given": "Martin", "initials": "M"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L"}, {"family": "Ford", "given": "Ian", "initials": "I"}, {"family": "Franke", "given": "Lude", "initials": "L", "orcid": "0000-0002-5159-8802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0a825c1d31c458e872fa6c79d30f02e.json"}}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8263a26f474946de8b61a2080051d37b.json"}}, {"family": "Froguel", "given": "Philippe", "initials": "P"}, {"family": "Gansevoort", "given": "Ron T", "initials": "RT"}, {"family": "Gieger", "given": "Christian", "initials": "C"}, {"family": "Gr\u00f6nberg", "given": "Henrik", "initials": "H", "orcid": "0000-0002-1073-2753", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33927307bf964b2fa09e09c0c867b542.json"}}, {"family": "Gudnason", "given": "Vilmundur", "initials": "V"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}}, {"family": "Hall", "given": "Per", "initials": "P"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "van der Harst", "given": "Pim", "initials": "P"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Heli\u00f6vaara", "given": "Markku", "initials": "M"}, {"family": "Hengstenberg", "given": "Christian", "initials": "C"}, {"family": "Hicks", "given": "Andrew A", "initials": "AA", "orcid": "0000-0001-6320-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08bfcbd859e848698883ad840f02594f.json"}}, {"family": "Hingorani", "given": "Aroon", "initials": "A"}, {"family": "Hofman", "given": "Albert", "initials": "A"}, {"family": "Hu", "given": "Frank", "initials": "F"}, {"family": "Huikuri", "given": "Heikki V", "initials": "HV"}, {"family": "Hveem", "given": "Kristian", "initials": "K"}, {"family": "James", "given": "Alan L", "initials": "AL"}, {"family": "Jordan", "given": "Joanne M", "initials": "JM"}, {"family": "Jula", "given": "Antti", "initials": "A"}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Kajantie", "given": "Eero", "initials": "E"}, {"family": "Kathiresan", "given": "Sekar", "initials": "S", "orcid": "0000-0002-6724-032X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc6443809e2048b189070618dbf870ba.json"}}, {"family": "Kiemeney", "given": "Lambertus A L M", "initials": "LA"}, {"family": "Kivimaki", "given": "Mika", "initials": "M", "orcid": "0000-0002-4699-5627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59d7f4b1a8f8464eba40b0abe733aae9.json"}}, {"family": "Knekt", "given": "Paul B", "initials": "PB"}, {"family": "Koistinen", "given": "Heikki A", "initials": "HA"}, {"family": "Kooner", "given": "Jaspal S", "initials": "JS"}, {"family": "Koskinen", "given": "Seppo", "initials": "S"}, {"family": "Kuusisto", "given": "Johanna", "initials": "J"}, {"family": "Maerz", "given": "Winfried", "initials": "W"}, {"family": "Martin", "given": "Nicholas G", "initials": "NG"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Lakka", "given": "Timo A", "initials": "TA"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Lettre", "given": "Guillaume", "initials": "G"}, {"family": "Levinson", "given": "Douglas F", "initials": "DF"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Lokki", "given": "Marja-Liisa", "initials": "ML"}, {"family": "M\u00e4ntyselk\u00e4", "given": "Pekka", "initials": "P"}, {"family": "Melbye", "given": "Mads", "initials": "M"}, {"family": "Metspalu", "given": "Andres", "initials": "A"}, {"family": "Mitchell", "given": "Braxton D", "initials": "BD", "orcid": "0000-0003-4920-4744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/421a0966308444a481cb485753a4fa44.json"}}, {"family": "Moll", "given": "Frans L", "initials": "FL"}, {"family": "Murray", "given": "Jeffrey C", "initials": "JC"}, {"family": "Musk", "given": "Arthur W", "initials": "AW"}, {"family": "Nieminen", "given": "Markku S", "initials": "MS"}, {"family": "Nj\u00f8lstad", "given": "Inger", "initials": "I"}, {"family": "Ohlsson", "given": "Claes", "initials": "C"}, {"family": "Oldehinkel", "given": "Albertine J", "initials": "AJ"}, {"family": "Oostra", "given": "Ben A", "initials": "BA"}, {"family": "Palmer", "given": "Lyle J", "initials": "LJ"}, {"family": "Pankow", "given": "James S", "initials": "JS"}, {"family": "Pasterkamp", "given": "Gerard", "initials": "G"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Penninx", "given": "Brenda W", "initials": "BW"}, {"family": "Perola", "given": "Markus", "initials": "M"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Pola\u0161ek", "given": "Ozren", "initials": "O"}, {"family": "Pramstaller", "given": "Peter P", "initials": "PP"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM", "orcid": "0000-0002-7278-2190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b4dfcdad9074df781cd6c8f3c303789.json"}}, {"family": "Qi", "given": "Lu", "initials": "L"}, {"family": "Quertermous", "given": "Thomas", "initials": "T"}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "Rankinen", "given": "Tuomo", "initials": "T"}, {"family": "Rauramaa", "given": "Rainer", "initials": "R"}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Rioux", "given": "John D", "initials": "JD"}, {"family": "Rivadeneira", "given": "Fernando", "initials": "F"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI", "orcid": "0000-0001-7191-1723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50edc25b80cc48b699db367e372fded5.json"}}, {"family": "Rudan", "given": "Igor", "initials": "I"}, {"family": "den Ruijter", "given": "Hester M", "initials": "HM"}, {"family": "Saltevo", "given": "Juha", "initials": "J"}, {"family": "Sattar", "given": "Naveed", "initials": "N"}, {"family": "Schunkert", "given": "Heribert", "initials": "H"}, {"family": "Schwarz", "given": "Peter E H", "initials": "PE"}, {"family": "Shuldiner", "given": "Alan R", "initials": "AR", "orcid": "0000-0001-9921-4305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74986bb485984a1b8bb58e4fed676ab1.json"}}, {"family": "Sinisalo", "given": "Juha", "initials": "J"}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "S\u00f8rensen", "given": "Thorkild I A", "initials": "TI"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Stefania", "given": "Bandinelli", "initials": "B"}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Stumvoll", "given": "Michael", "initials": "M"}, {"family": "Tardif", "given": "Jean-Claude", "initials": "JC"}, {"family": "Tremoli", "given": "Elena", "initials": "E"}, {"family": "Tuomilehto", "given": "Jaakko", "initials": "J"}, {"family": "Uitterlinden", "given": "Andr\u00e9 G", "initials": "AG"}, {"family": "Uusitupa", "given": "Matti", "initials": "M"}, {"family": "Verbeek", "given": "Andr\u00e9 L M", "initials": "AL"}, {"family": "Vermeulen", "given": "Sita H", "initials": "SH"}, {"family": "Viikari", "given": "Jorma S", "initials": "JS"}, {"family": "Vitart", "given": "Veronique", "initials": "V"}, {"family": "V\u00f6lzke", "given": "Henry", "initials": "H"}, {"family": "Vollenweider", "given": "Peter", "initials": "P"}, {"family": "Waeber", "given": "G\u00e9rard", "initials": "G"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Wallaschofski", "given": "Henri", "initials": "H"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Watkins", "given": "Hugh", "initials": "H"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E"}, {"family": "CHARGE Consortium", "given": "", "initials": ""}, {"family": "DIAGRAM Consortium", "given": "", "initials": ""}, {"family": "GLGC Consortium", "given": "", "initials": ""}, {"family": "Global-BPGen Consortium", "given": "", "initials": ""}, {"family": "ICBP Consortium", "given": "", "initials": ""}, {"family": "MAGIC Consortium", "given": "", "initials": ""}, {"family": "Chakravarti", "given": "Aravinda", "initials": "A"}, {"family": "Clegg", "given": "Deborah J", "initials": "DJ"}, {"family": "Cupples", "given": "L Adrienne", "initials": "LA"}, {"family": "Gordon-Larsen", "given": "Penny", "initials": "P"}, {"family": "Jaquish", "given": "Cashell E", "initials": "CE"}, {"family": "Rao", "given": "D C", "initials": "DC"}, {"family": "Abecasis", "given": "Goncalo R", "initials": "GR"}, {"family": "Assimes", "given": "Themistocles L", "initials": "TL", "orcid": "0000-0003-2349-0009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/610f47c94b0c4fe2bb2da6921aa8a1ef.json"}}, {"family": "Barroso", "given": "In\u00eas", "initials": "I"}, {"family": "Berndt", "given": "Sonja I", "initials": "SI"}, {"family": "Boehnke", "given": "Michael", "initials": "M"}, {"family": "Deloukas", "given": "Panos", "initials": "P", "orcid": "0000-0001-9251-070X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d034d0cd32a84b959bd29f8ef8c91979.json"}}, {"family": "Fox", "given": "Caroline S", "initials": "CS"}, {"family": "Groop", "given": "Leif C", "initials": "LC"}, {"family": "Hunter", "given": "David J", "initials": "DJ"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Kaplan", "given": "Robert C", "initials": "RC"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Mohlke", "given": "Karen L", "initials": "KL"}, {"family": "O'Connell", "given": "Jeffrey R", "initials": "JR"}, {"family": "Schlessinger", "given": "David", "initials": "D"}, {"family": "Strachan", "given": "David P", "initials": "DP"}, {"family": "Stefansson", "given": "Kari", "initials": "K", "orcid": "0000-0003-1676-864X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9edf80871ac84e76a4d1316fc7079d7d.json"}}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM"}, {"family": "Hirschhorn", "given": "Joel N", "initials": "JN"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "North", "given": "Kari E", "initials": "KE", "orcid": "0000-0002-8903-0366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d43affb5fa064e0d98d5b6e5cd017461.json"}}, {"family": "Borecki", "given": "Ingrid B", "initials": "IB"}, {"family": "Kutalik", "given": "Zolt\u00e1n", "initials": "Z", "orcid": "0000-0001-8285-7523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e566b994d65a4365b224cd4ae369827a.json"}}, {"family": "Loos", "given": "Ruth J F", "initials": "RJ", "orcid": "0000-0002-8532-5087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/179eb6511eba4d33b633599c5652e344.json"}}], "type": "journal article", "published": "2015-10-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "11", "issue": "10", "pages": "e1005378", "issn-l": "1553-7390"}, "abstract": "Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men \u226450y, men >50y, women \u226450y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (\u226550y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. ", "doi": "10.1371/journal.pgen.1005378", "pmid": "26426971", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "PGENETICS-D-14-03117"}, {"db": "pmc", "key": "PMC4591371"}], "notes": [], "created": "2018-12-05T08:45:37.291Z", "modified": "2025-11-30T11:22:50.301Z"}]}