{"entity": "researcher", "timestamp": "2026-09-26T00:43:51.343Z", "family": "Str\u00f6mblad", "given": "Staffan", "initials": "S", "orcid": "0000-0002-1236-6339", "affiliations": ["Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden staffan.stromblad@ki.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/eaaec7c2564a4cb5827a794027518796.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/eaaec7c2564a4cb5827a794027518796"}}, "publications": [{"entity": "publication", "iuid": "f5aa84a9852742eeb7c097da2a0a9e4f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f5aa84a9852742eeb7c097da2a0a9e4f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f5aa84a9852742eeb7c097da2a0a9e4f"}}, "title": "An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer.", "authors": [{"family": "S\u00f6derqvist", "given": "Sara", "initials": "S"}, {"family": "Viljamaa", "given": "Annika", "initials": "A", "orcid": "0009-0002-8511-8181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad54bd86380f48b99fc405a6466f5e5e.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N"}, {"family": "Keller", "given": "Anna-Lena", "initials": "AL"}, {"family": "Ruksha", "given": "Kseniya", "initials": "K"}, {"family": "Strell", "given": "Carina", "initials": "C", "orcid": "0000-0002-3783-7256", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f288539ea7eb406480c84ec1a5605a91.json"}}, {"family": "Hekmati", "given": "Neda", "initials": "N"}, {"family": "Niculae", "given": "Alexandra", "initials": "A"}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Salm\u00e9n", "given": "Caroline", "initials": "C"}, {"family": "Costa", "given": "T\u00e2nia D F", "initials": "TDF", "orcid": "0000-0002-6296-5225", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93606f4fc34a4e088f63303d4bb9b7dc.json"}}, {"family": "Zhao", "given": "Miao", "initials": "M", "orcid": "0000-0002-4895-1177", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75b5d6dc5cde46b8aca859fb961bf1de.json"}}, {"family": "Str\u00f6mblad", "given": "Staffan", "initials": "S", "orcid": "0000-0002-1236-6339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eaaec7c2564a4cb5827a794027518796.json"}}, {"family": "Zacharouli", "given": "Argyro", "initials": "A"}, {"family": "Ghorbani", "given": "Poya", "initials": "P"}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Milanova", "given": "Stefina", "initials": "S"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Fern\u00e1ndez Moro", "given": "Carlos", "initials": "C", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "journal article", "published": "2025-09-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8307", "issn-l": "2041-1723"}, "abstract": "Pancreatic cancer is an aggressive disease with a dense fibrotic stroma and is often accompanied by chronic inflammation. Peritumoral inflammation is typically viewed as a reaction to nearby tumor growth. Here, we report that the inflamed pancreatic lobules are frequently invaded by tumor cells, forming a distinct, non-fibrotic tumor niche. Using a semi-supervised machine learning approach for annotations of clinical samples and multiplex protein profiling, we show that tumor cells at the invasion front are closely associated with acinar cells undergoing damage-induced changes, and with activated fibroblasts expressing markers of injury. The invaded lobules are linked to classical tumor phenotypes, in contrast to fibrotic areas where tumor cells display a more basal profile, highlighting microenvironment-dependent tumor subtype differences. In female mice, lobular invasion similarly aligns with the classical tumor phenotype. Together, our data reveal that pancreatic tumors colonize injured lobules, creating a unique niche that shapes tumor characteristics and contributes to disease biology.", "doi": "10.1038/s41467-025-63864-7", "pmid": "41006303", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12475445"}, {"db": "pii", "key": "10.1038/s41467-025-63864-7"}], "notes": [], "created": "2026-09-23T11:34:17.684Z", "modified": "2026-09-23T11:34:17.901Z"}, {"entity": "publication", "iuid": "ccfdd4ef24174d7d80dd99a82207b179", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ccfdd4ef24174d7d80dd99a82207b179.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ccfdd4ef24174d7d80dd99a82207b179"}}, "title": "Active and inactive \u03b21 integrins segregate into distinct nanoclusters in focal adhesions.", "authors": [{"family": "Spiess", "given": "Matthias", "initials": "M"}, {"family": "Hernandez-Varas", "given": "Pablo", "initials": "P"}, {"family": "Oddone", "given": "Anna", "initials": "A", "orcid": "0000-0002-8348-3073", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d93ebc7adf8649b4b4d95a061f63250b.json"}}, {"family": "Olofsson", "given": "Helene", "initials": "H"}, {"family": "Blom", "given": "Hans", "initials": "H"}, {"family": "Waithe", "given": "Dominic", "initials": "D", "orcid": "0000-0003-2685-4226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d8dc3cd02e1470599d4842b3546f9d0.json"}}, {"family": "Lock", "given": "John G", "initials": "JG"}, {"family": "Lakadamyali", "given": "Melike", "initials": "M", "orcid": "0000-0002-7524-6414", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d32b52e3d3bb451f9a6e39e3586af474.json"}}, {"family": "Str\u00f6mblad", "given": "Staffan", "initials": "S", "orcid": "0000-0002-1236-6339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eaaec7c2564a4cb5827a794027518796.json"}}], "type": "journal article", "published": "2018-06-04", "journal": {"title": "J. Cell Biol.", "issn": "1540-8140", "volume": "217", "issue": "6", "pages": "1929-1940", "issn-l": "0021-9525"}, "abstract": "Integrins are the core constituents of cell-matrix adhesion complexes such as focal adhesions (FAs) and play key roles in physiology and disease. Integrins fluctuate between active and inactive conformations, yet whether the activity state influences the spatial organization of integrins within FAs has remained unclear. In this study, we address this question and also ask whether integrin activity may be regulated either independently for each integrin molecule or through locally coordinated mechanisms. We used two distinct superresolution microscopy techniques, stochastic optical reconstruction microscopy (STORM) and stimulated emission depletion microscopy (STED), to visualize active versus inactive \u03b21 integrins. We first reveal a spatial hierarchy of integrin organization with integrin molecules arranged in nanoclusters, which align to form linear substructures that in turn build FAs. Remarkably, within FAs, active and inactive \u03b21 integrins segregate into distinct nanoclusters, with active integrin nanoclusters being more organized. This unexpected segregation indicates synchronization of integrin activities within nanoclusters, implying the existence of a coordinate mechanism of integrin activity regulation.", "doi": "10.1083/jcb.201707075", "pmid": "29632027", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5987715"}, {"db": "pii", "key": "jcb.201707075"}], "notes": [], "created": "2019-01-17T13:53:43.772Z", "modified": "2026-09-23T07:37:15.546Z"}]}