{"entity": "researcher", "timestamp": "2026-09-26T23:46:15.418Z", "family": "Gruzieva", "given": "Olena", "initials": "O", "orcid": "0000-0003-4147-5654", "affiliations": ["Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.", "Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea131c862a264e4baac6e53e0cfbc9f7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea131c862a264e4baac6e53e0cfbc9f7"}}, "publications": [{"entity": "publication", "iuid": "fe04d09c101f4ebba4c16e5036d56576", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fe04d09c101f4ebba4c16e5036d56576.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fe04d09c101f4ebba4c16e5036d56576"}}, "title": "DNA Methylation Trajectories During Pregnancy.", "authors": [{"family": "Gruzieva", "given": "Olena", "initials": "O", "orcid": "0000-0003-4147-5654", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea131c862a264e4baac6e53e0cfbc9f7.json"}}, {"family": "Merid", "given": "Simon Kebede", "initials": "SK"}, {"family": "Chen", "given": "Su", "initials": "S"}, {"family": "Mukherjee", "given": "Nandini", "initials": "N"}, {"family": "Hedman", "given": "Anna M", "initials": "AM"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}, {"family": "Andolf", "given": "Ellika", "initials": "E"}, {"family": "Jiang", "given": "Yu", "initials": "Y"}, {"family": "Kere", "given": "Juha", "initials": "J"}, {"family": "Scheynius", "given": "Annika", "initials": "A"}, {"family": "S\u00f6derh\u00e4ll", "given": "Cilla", "initials": "C"}, {"family": "Ullemar", "given": "Vilhelmina", "initials": "V"}, {"family": "Karmaus", "given": "Wilfried", "initials": "W"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E"}, {"family": "Arshad", "given": "Syed Hasan", "initials": "SH"}, {"family": "Pershagen", "given": "G\u00f6ran", "initials": "G"}], "type": "journal article", "published": "2019-08-13", "journal": {"title": "Epigenet Insights", "issn": "2516-8657", "volume": "12", "pages": "2516865719867090", "issn-l": null}, "abstract": "There is emerging evidence on DNA methylation (DNAm) variability over time; however, little is known about dynamics of DNAm patterns during pregnancy. We performed an epigenome-wide longitudinal DNAm study of a well-characterized sample of young women from the Swedish Born into Life study, with repeated blood sampling before, during and after pregnancy (n = 21), using the Illumina Infinium MethylationEPIC array. We conducted a replication in the Isle of Wight third-generation birth cohort (n = 27), using the Infinium HumanMethylation450k BeadChip. We identified 196 CpG sites displaying intra-individual longitudinal change in DNAm with a false discovery rate (FDR) P < .05. Most of these (91%) showed a decrease in average methylation levels over the studied period. We observed several genes represented by \u2a7e3 differentially methylated CpGs: HOXB3, AVP, LOC100996291, and MicroRNA 10a. Of 36 CpGs available in the replication cohort, 17 were replicated, all but 2 with the same direction of association (replication P < .05). Biological pathway analysis demonstrated that FDR-significant CpGs belong to genes overrepresented in metabolism-related pathways, such as adipose tissue development, regulation of insulin receptor signaling, and mammary gland fat development. These results contribute to a better understanding of the biological mechanisms underlying important physiological alterations and adaptations for pregnancy and lactation.", "doi": "10.1177/2516865719867090", "pmid": "31453433", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6696836"}, {"db": "pii", "key": "10.1177_2516865719867090"}], "notes": [], "created": "2026-09-23T09:21:56.461Z", "modified": "2026-09-23T09:21:56.536Z"}]}