{"entity": "researcher", "timestamp": "2026-09-24T02:38:15.598Z", "family": "Frapard", "given": "Sol\u00e8ne", "initials": "S", "orcid": "0000-0002-2649-7225", "affiliations": ["Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e911ee0112d04fe89b254e4624490460.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e911ee0112d04fe89b254e4624490460"}}, "publications": [{"entity": "publication", "iuid": "f98dbb1664c44b5a8643ba272b89f74c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f98dbb1664c44b5a8643ba272b89f74c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f98dbb1664c44b5a8643ba272b89f74c"}}, "title": "Claustrum and dorsal endopiriform cortex complex cell-identity is determined by Nurr1 and regulates hallucinogenic-like states in mice.", "authors": [{"family": "Mantas", "given": "Ioannis", "initials": "I", "orcid": "0000-0001-6288-5439", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1039fe5afaeb467ebfbfc5b99a4a13b9.json"}}, {"family": "Flais", "given": "Ivana", "initials": "I"}, {"family": "Masarapu", "given": "Yuvarani", "initials": "Y", "orcid": "0000-0002-3267-2085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecae6e58dddd40b7a547bd7eb38aa4fd.json"}}, {"family": "Ionescu", "given": "Tudor", "initials": "T"}, {"family": "Frapard", "given": "Sol\u00e8ne", "initials": "S", "orcid": "0000-0002-2649-7225", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e911ee0112d04fe89b254e4624490460.json"}}, {"family": "Jung", "given": "Felix", "initials": "F"}, {"family": "Le Merre", "given": "Pierre", "initials": "P", "orcid": "0000-0003-4205-7411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ebebeabbd3a4bc89ea05d00cc47013a.json"}}, {"family": "Saarinen", "given": "Marcus", "initials": "M"}, {"family": "Tiklova", "given": "Katarina", "initials": "K"}, {"family": "Salmani", "given": "Behzad Yaghmaeian", "initials": "BY", "orcid": "0000-0002-4221-6243", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a2cd9cba2dc43f29a4fff6d0c729c83.json"}}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X", "orcid": "0000-0002-9461-8682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4395a11b24bf40308b6d3a8467763517.json"}}, {"family": "Chergui", "given": "Karima", "initials": "K"}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a9c4a7494ba4284ab52158e6cbc85da.json"}}, {"family": "Hengerer", "given": "Bastian", "initials": "B", "orcid": "0000-0002-7811-9795", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/baaddee4cd7548998431491d4d85d14e.json"}}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}], "type": "journal article", "published": "2024-09-18", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "8176", "issn-l": "2041-1723"}, "abstract": "The Claustrum/dorsal endopiriform cortex complex (CLA) is an enigmatic brain region with extensive glutamatergic projections to multiple cortical areas. The transcription factor Nurr1 is highly expressed in the CLA, but its role in this region is not understood. By using conditional gene-targeted mice, we show that Nurr1 is a crucial regulator of CLA neuron identity. Although CLA neurons remain intact in the absence of Nurr1, the distinctive gene expression pattern in the CLA is abolished. CLA has been hypothesized to control hallucinations, but little is known of how the CLA responds to hallucinogens. After the deletion of Nurr1 in the CLA, both hallucinogen receptor expression and signaling are lost. Furthermore, functional ultrasound and Neuropixel electrophysiological recordings revealed that the hallucinogenic-receptor agonists' effects on functional connectivity between prefrontal and sensorimotor cortices are altered in Nurr1-ablated mice. Our findings suggest that Nurr1-targeted strategies provide additional avenues for functional studies of the CLA.", "doi": "10.1038/s41467-024-52429-9", "pmid": "39289358", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11408527"}, {"db": "pii", "key": "10.1038/s41467-024-52429-9"}, {"db": "GEO", "key": "GSE229770"}, {"db": "GEO", "key": "GSE229732"}], "notes": [], "created": "2026-09-23T11:12:28.263Z", "modified": "2026-09-23T11:12:28.442Z"}, {"entity": "publication", "iuid": "fde18c9d8655405ab17f536d4358b325", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fde18c9d8655405ab17f536d4358b325.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fde18c9d8655405ab17f536d4358b325"}}, "title": "Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice.", "authors": [{"family": "Masarapu", "given": "Yuvarani", "initials": "Y", "orcid": "0000-0002-3267-2085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecae6e58dddd40b7a547bd7eb38aa4fd.json"}}, {"family": "Cekanaviciute", "given": "Egle", "initials": "E", "orcid": "0000-0003-3306-1806", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44f617fae1ec4a5e93e6e5393d74aa1b.json"}}, {"family": "Andrusivova", "given": "Zaneta", "initials": "Z"}, {"family": "Westholm", "given": "Jakub O", "initials": "JO", "orcid": "0000-0002-6849-6220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/966341b184974f0f81c34e36cadd74e0.json"}}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Fallegger", "given": "Robin", "initials": "R", "orcid": "0000-0003-3264-6028", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c0497384810432fb0a9e166ece4712f.json"}}, {"family": "Badia-I-Mompel", "given": "Pau", "initials": "P", "orcid": "0000-0002-1004-3923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1840e6190eae436f86ee079f4364d45f.json"}}, {"family": "Boyko", "given": "Valery", "initials": "V", "orcid": "0000-0002-3724-9294", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92a4153a548e40948f1da9aa104d91f0.json"}}, {"family": "Vasisht", "given": "Shubha", "initials": "S"}, {"family": "Saravia-Butler", "given": "Amanda", "initials": "A"}, {"family": "Gebre", "given": "Samrawit", "initials": "S"}, {"family": "L\u00e1z\u00e1r", "given": "Enik\u0151", "initials": "E", "orcid": "0000-0001-8664-7531", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/422fbfd83b1646e28d5021ac7b8f598c.json"}}, {"family": "Graziano", "given": "Marta", "initials": "M"}, {"family": "Frapard", "given": "Sol\u00e8ne", "initials": "S", "orcid": "0000-0002-2649-7225", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e911ee0112d04fe89b254e4624490460.json"}}, {"family": "Hinshaw", "given": "Robert G", "initials": "RG", "orcid": "0000-0003-0060-7753", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b695d8a6535e43419c64a2a5587c78c9.json"}}, {"family": "Bergmann", "given": "Olaf", "initials": "O", "orcid": "0000-0003-1065-4107", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5c930ddb65b49a4962c6c3d223e39ea.json"}}, {"family": "Taylor", "given": "Deanne M", "initials": "DM", "orcid": "0000-0002-3302-4610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08e1b154497e47629b28f27ea5e14ed3.json"}}, {"family": "Wallace", "given": "Douglas C", "initials": "DC", "orcid": "0000-0002-7480-8278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e305f45b4ac4631a6cd05d2a426b6c1.json"}}, {"family": "Sylv\u00e9n", "given": "Christer", "initials": "C"}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314d93feac4048799b81ca9cb04fc078.json"}}, {"family": "Saez-Rodriguez", "given": "Julio", "initials": "J", "orcid": "0000-0002-8552-8976", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/504df2e61c124714b9afecf767798a00.json"}}, {"family": "Galazka", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-4153-0249", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8ee9225af3242c694262e35105782b9.json"}}, {"family": "Costes", "given": "Sylvain V", "initials": "SV", "orcid": "0000-0002-8542-2389", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05e9f957d1fa4a6bb16528119f2d71bc.json"}}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a9c4a7494ba4284ab52158e6cbc85da.json"}}], "type": "journal article", "published": "2024-06-11", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "4778", "issn-l": "2041-1723"}, "abstract": "Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate the impact of spaceflight on the mouse brain in female mice. Our comparative analysis between ground control and spaceflight-exposed animals revealed significant alterations in essential brain processes including neurogenesis, synaptogenesis and synaptic transmission, particularly affecting the cortex, hippocampus, striatum and neuroendocrine structures. Additionally, we observed astrocyte activation and signs of immune dysfunction. At the pathway level, some spaceflight-induced changes in the brain exhibit similarities with neurodegenerative disorders, marked by oxidative stress and protein misfolding. Our integrated spatial multiomics approach serves as a stepping stone towards understanding spaceflight-induced CNS impairments at the level of individual brain regions and cell types, and provides a basis for comparison in future spaceflight studies. For broader scientific impact, all datasets from this study are available through an interactive data portal, as well as the National Aeronautics and Space Administration (NASA) Open Science Data Repository (OSDR).", "doi": "10.1038/s41467-024-48916-8", "pmid": "38862479", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11166911"}, {"db": "pii", "key": "10.1038/s41467-024-48916-8"}], "notes": [], "created": "2026-09-23T09:04:16.331Z", "modified": "2026-09-23T09:04:17.047Z"}]}