{"entity": "researcher", "timestamp": "2026-09-30T01:54:50.952Z", "family": "Tremlett", "given": "Helen", "initials": "H", "orcid": "0000-0001-5804-2535", "affiliations": ["Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. helen.tremlett@ubc.ca."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e885cbe51def496aa35ad882105f4de5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e885cbe51def496aa35ad882105f4de5"}}, "publications": [{"entity": "publication", "iuid": "4d5901dbcd4348daa8c85c8f8945dabb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4d5901dbcd4348daa8c85c8f8945dabb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4d5901dbcd4348daa8c85c8f8945dabb"}}, "title": "Common variation near IRF6 is associated with IFN-\u03b2-induced liver injury in multiple sclerosis.", "authors": [{"family": "Kowalec", "given": "Kaarina", "initials": "K"}, {"family": "Wright", "given": "Galen E B", "initials": "GEB", "orcid": "0000-0003-2415-7339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba835e4dce8440b480c6e8ab980b77b0.json"}}, {"family": "Dr\u00f6gem\u00f6ller", "given": "Britt I", "initials": "BI", "orcid": "0000-0002-3348-5855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57e3e42631ae4552a386d0d105e48639.json"}}, {"family": "Aminkeng", "given": "Folefac", "initials": "F"}, {"family": "Bhavsar", "given": "Amit P", "initials": "AP"}, {"family": "Kingwell", "given": "Elaine", "initials": "E"}, {"family": "Yoshida", "given": "Eric M", "initials": "EM"}, {"family": "Traboulsee", "given": "Anthony", "initials": "A"}, {"family": "Marrie", "given": "Ruth Ann", "initials": "RA"}, {"family": "Kremenchutzky", "given": "Marcelo", "initials": "M"}, {"family": "Campbell", "given": "Trudy L", "initials": "TL"}, {"family": "Duquette", "given": "Pierre", "initials": "P"}, {"family": "Chalasani", "given": "Naga", "initials": "N"}, {"family": "Wadelius", "given": "Mia", "initials": "M", "orcid": "0000-0002-6368-2622", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a663f51c194a8f8060b6fa54f11ac6.json"}}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P"}, {"family": "Xia", "given": "Zongqi", "initials": "Z"}, {"family": "De Jager", "given": "Philip L", "initials": "PL", "orcid": "0000-0002-8057-2505", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4684858b1fd74dab972859106e0e50a0.json"}}, {"family": "Denny", "given": "Joshua C", "initials": "JC"}, {"family": "Davis", "given": "Mary F", "initials": "MF"}, {"family": "Ross", "given": "Colin J D", "initials": "CJD"}, {"family": "Tremlett", "given": "Helen", "initials": "H", "orcid": "0000-0001-5804-2535", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e885cbe51def496aa35ad882105f4de5.json"}}, {"family": "Carleton", "given": "Bruce C", "initials": "BC"}], "type": "journal article", "published": "2018-08-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "50", "issue": "8", "pages": "1081-1085", "issn-l": "1061-4036"}, "abstract": "Multiple sclerosis (MS) is a disease of the central nervous system treated with disease-modifying therapies, including the biologic, interferon-\u03b2 (IFN-\u03b2). Up to 60% of IFN-\u03b2-exposed MS patients develop abnormal biochemical liver test results1,2, and 1 in 50 experiences drug-induced liver injury3. Since genomic variation contributes to other forms of drug-induced liver injury4,5, we aimed to identify biomarkers of IFN-\u03b2-induced liver injury using a two-stage genome-wide association study. The rs2205986 variant, previously linked to differential expression of IRF6, surpassed genome-wide significance in the combined two-stage analysis (P = 2.3 \u00d7 10-8, odds ratio = 8.3, 95% confidence interval = 3.6-19.2). Analysis of an independent cohort of IFN-\u03b2-treated MS patients identified via electronic medical records showed that rs2205986 was also associated with increased peak levels of aspartate aminotransferase (P = 7.6 \u00d7 10-5) and alkaline phosphatase (P = 4.9 \u00d7 10-4). We show that these findings may be applicable to predicting IFN-\u03b2-induced liver injury, offering insight into its safer use.", "doi": "10.1038/s41588-018-0168-y", "pmid": "30013178", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1021645"}, {"db": "pmc", "key": "PMC6513312"}, {"db": "pii", "key": "10.1038/s41588-018-0168-y"}], "notes": [], "created": "2019-01-17T13:56:55.215Z", "modified": "2026-09-23T10:18:17.508Z"}]}