{"entity": "researcher", "timestamp": "2026-08-22T08:32:48.352Z", "family": "Akinola", "given": "Lois S", "initials": "LS", "orcid": "0000-0003-0168-4515", "affiliations": ["Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e84f88e142504d62a041a17112f5d911.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e84f88e142504d62a041a17112f5d911"}}, "publications": [{"entity": "publication", "iuid": "368fd135e8d64a3095568ade8c3c4f04", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/368fd135e8d64a3095568ade8c3c4f04.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/368fd135e8d64a3095568ade8c3c4f04"}}, "title": "Pharmacological characterization of 5-iodo-A-85380, a \u03b22-selective nicotinic receptor agonist, in mice.", "authors": [{"family": "Akinola", "given": "Lois S", "initials": "LS", "orcid": "0000-0003-0168-4515", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e84f88e142504d62a041a17112f5d911.json"}}, {"family": "Bagdas", "given": "Deniz", "initials": "D"}, {"family": "Alkhlaif", "given": "Yasmin", "initials": "Y"}, {"family": "Jackson", "given": "Asti", "initials": "A"}, {"family": "Gurdap", "given": "Cenk O", "initials": "CO", "orcid": "0000-0002-5327-2523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/caec9f4233794290bc6b96b11fde5c1d.json"}}, {"family": "Rahimpour", "given": "Elnaz", "initials": "E"}, {"family": "Carroll", "given": "F Ivy", "initials": "FI"}, {"family": "Papke", "given": "Roger L", "initials": "RL"}, {"family": "Damaj", "given": "M Imad", "initials": "MI"}], "type": "journal article", "published": "2022-11-00", "journal": {"title": "J Psychopharmacol", "issn": "1461-7285", "volume": "36", "issue": "11", "pages": "1280-1293", "issn-l": null}, "abstract": "Because of their implications in several pathological conditions, \u03b14\u03b22* nicotinic acetylcholine receptors (nAChRs) are potential targets for the treatment of nicotine dependence, pain, and many psychiatric and neurodegenerative diseases. However, they exist in various subtypes, and finding selective tools to investigate them has proved challenging. The nicotinic receptor agonist, 5-iodo-A-85380 (5IA), has helped in delineating the function of \u03b22-containing subtypes in vitro; however, much is still unknown about its behavioral effects. Furthermore, its effectiveness on \u03b16-containing subtypes is limited.\n\nTo investigate the effects of 5IA on nociception (formalin, hot-plate, and tail-flick tests), locomotion, hypothermia, and conditioned reward after acute and repeated administration, and to examine the potential role of \u03b22 and \u03b16 nAChR subunits in these effects. Lastly, its selectivity for expressed low sensitivity (LS) and high sensitivity (HS) \u03b14\u03b22 receptors is investigated.\n\n5IA dose-dependently induced hypothermia, locomotion suppression, conditioned place preference, and antinociception (only in the formalin test but not in the hot-plate or tail-flick tests). Furthermore, these effects were mediated by \u03b22 but not \u03b16 nicotinic subunits. Finally, we show that 5-iodo-A-85380 potently activates both stoichiometries of \u03b14\u03b22 nAChRs with differential efficacies, being a full agonist on HS \u03b14(2)\u03b22(3) nAChRs, and a partial agonist on LS \u03b14(3)\u03b22(2) nAChRs and \u03b16-containing subtypes as well.", "doi": "10.1177/02698811221132214", "pmid": "36321267", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9817006"}, {"db": "mid", "key": "NIHMS1851381"}], "notes": [], "created": "2026-08-21T12:31:59.374Z", "modified": "2026-08-21T12:31:59.472Z"}]}