{"entity": "researcher", "timestamp": "2026-08-20T20:49:10.565Z", "family": "Weiss", "given": "Tamina", "initials": "T", "orcid": "0009-0002-3605-0782", "affiliations": ["Wallenberg Centre for Molecular Medicine, Link\u00f6ping University, Link\u00f6ping 58183, Sweden.", "Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Faculty of Medicine and Health Sciences, Link\u00f6ping University, Link\u00f6ping 58225, Sweden.", "Science for Life Laboratory, SciLifeLab, Link\u00f6ping University, Link\u00f6ping 58183, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e72c8aa90d334d09a4f6f3c627ada8e2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e72c8aa90d334d09a4f6f3c627ada8e2"}}, "publications": [{"entity": "publication", "iuid": "7550b994b8cb4629bb0ebde41fec44d0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7550b994b8cb4629bb0ebde41fec44d0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7550b994b8cb4629bb0ebde41fec44d0"}}, "title": "The developmental factor TBX3 engages with the Wnt/\u03b2-catenin transcriptional complex in colorectal cancer to regulate metastasis genes.", "authors": [{"family": "Jauregi-Miguel", "given": "Amaia", "initials": "A", "orcid": "0000-0003-0938-7734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07967f3c084142c0a0d257a3b94c7bfa.json"}}, {"family": "S\u00f6derholm", "given": "Simon", "initials": "S", "orcid": "0000-0001-5350-7102", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e7e40c649fa49ed9ffe794d176fc899.json"}}, {"family": "Weiss", "given": "Tamina", "initials": "T", "orcid": "0009-0002-3605-0782", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e72c8aa90d334d09a4f6f3c627ada8e2.json"}}, {"family": "Nordin", "given": "Anna", "initials": "A", "orcid": "0000-0002-5868-4797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8bef8cedd8544225bfec5435b7dfa597.json"}}, {"family": "Ghezzi", "given": "Valeria", "initials": "V"}, {"family": "Br\u00fctsch", "given": "Salome M", "initials": "SM"}, {"family": "Pagella", "given": "Pierfrancesco", "initials": "P"}, {"family": "van de Grift", "given": "Yorick", "initials": "Y", "orcid": "0000-0003-0920-9030", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04cc508af3b44bf19170368d27e982a2.json"}}, {"family": "Zambanini", "given": "Gianluca", "initials": "G", "orcid": "0000-0003-1275-6027", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b00dff2c6ddf4b3e9177af40d612c558.json"}}, {"family": "Ulisse", "given": "Jacopo", "initials": "J", "orcid": "0000-0002-9371-9094", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42ed48fd6c9d4022a46da65e61f533e6.json"}}, {"family": "Mattia", "given": "Alessandro", "initials": "A", "orcid": "0009-0004-9008-8372", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea225a02717f427fb08f011dbf1b753f.json"}}, {"family": "Deviatiiarov", "given": "Ruslan", "initials": "R", "orcid": "0000-0003-0019-2076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/049ccf52c8b54a098f99f13a37c43b12.json"}}, {"family": "Faustini", "given": "Elena", "initials": "E", "orcid": "0009-0007-8549-4933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf70b5c38bb546479ac12f6bfea4e053.json"}}, {"family": "Moparthi", "given": "Lavanya", "initials": "L"}, {"family": "Zhong", "given": "Wenjing", "initials": "W"}, {"family": "Bj\u00f6rnsson", "given": "Bergthor", "initials": "B"}, {"family": "Sandstr\u00f6m", "given": "Per", "initials": "P", "orcid": "0000-0002-8078-9528", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57c3ae8e15b0405faa4328a39447cc38.json"}}, {"family": "Lundqvist", "given": "Erik", "initials": "E", "orcid": "0000-0001-5312-1023", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9b191ae3e864b81a055d93ae3a1b38a.json"}}, {"family": "Lottersberger", "given": "Francisca", "initials": "F", "orcid": "0000-0002-0677-8986", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7075525767d40b0bec6392c568ddb7e.json"}}, {"family": "Koch", "given": "Stefan", "initials": "S"}, {"family": "Moor", "given": "Andreas E", "initials": "AE", "orcid": "0000-0001-8715-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0ed89a4cc224a3c89c4cf5f577c95e1.json"}}, {"family": "Sun", "given": "Xiao-Feng", "initials": "XF", "orcid": "0000-0001-5804-9374", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7ebbd08fcb344b4a462fbfbbc456431.json"}}, {"family": "von Castelmur", "given": "Eleonore", "initials": "E", "orcid": "0000-0001-7061-4890", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dcabe716f43542e6a3a24d1eba14e5f8.json"}}, {"family": "Sheng", "given": "Guojun", "initials": "G"}, {"family": "Cant\u00f9", "given": "Claudio", "initials": "C", "orcid": "0000-0003-1547-5415", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf8cf56e956942f4baa10f2772c13734.json"}}], "type": "journal article", "published": "2025-05-13", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "122", "issue": "19", "pages": "e2419691122", "issn-l": "0027-8424"}, "abstract": "Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear \u03b2-catenin. Yet, little is known about how \u03b2-catenin generates context-specific transcriptional outcomes. Understanding this will reveal how aberrant Wnt/\u03b2-catenin signaling causes neoplasia specifically of the colorectal epithelium. We have previously identified the transcription factor TBX3 as a tissue-specific component of the Wnt/\u03b2-catenin nuclear complex during mouse forelimb development. In this study, we show that TBX3 is functionally active in human colorectal cancer (CRC). Here, genome-wide binding and transcriptomics analyses reveal that TBX3 regulates cancer metastasis genes in cooperation with Wnt/\u03b2-catenin. Proteomics proximity labeling performed across Wnt pathway activation shows that TBX3 engages with several transcription factors and chromatin remodeling complexes found at Wnt responsive elements (WRE). Protein sequence and structure analysis of TBX3 revealed short motifs, including an exposed Asn-Pro-Phe (NPF), that mediate these interactions. Deletion of these motifs abrogates TBX3's proximity to its protein partners and its ability to enhance the Wnt-dependent transcription. TBX3 emerges as a key modulator of the oncogenic activity of Wnt/\u03b2-catenin in CRC, and its mechanism of action exposes protein-interaction surfaces as putative druggable targets.", "doi": "10.1073/pnas.2419691122", "pmid": "40343989", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12088458"}], "notes": [], "created": "2026-08-20T09:31:48.379Z", "modified": "2026-08-20T09:31:49.077Z"}, {"entity": "publication", "iuid": "e63b7bef74d24951b7cafcd1cb96cd2c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e63b7bef74d24951b7cafcd1cb96cd2c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e63b7bef74d24951b7cafcd1cb96cd2c"}}, "title": "Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions.", "authors": [{"family": "Nordin", "given": "Anna", "initials": "A", "orcid": "0000-0002-5868-4797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8bef8cedd8544225bfec5435b7dfa597.json"}}, {"family": "Zambanini", "given": "Gianluca", "initials": "G", "orcid": "0000-0003-1275-6027", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b00dff2c6ddf4b3e9177af40d612c558.json"}}, {"family": "Enar Jonasson", "given": "Mattias", "initials": "M", "orcid": "0000-0001-5528-3405", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55518b46d2b646ccafa1c598c50cb2af.json"}}, {"family": "Weiss", "given": "Tamina", "initials": "T", "orcid": "0009-0002-3605-0782", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e72c8aa90d334d09a4f6f3c627ada8e2.json"}}, {"family": "van de Grift", "given": "Yorick", "initials": "Y"}, {"family": "Pagella", "given": "Pierfrancesco", "initials": "P", "orcid": "0000-0001-6912-0957", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3280806842e04b08a4b595b30e1eee3f.json"}}, {"family": "Cant\u00f9", "given": "Claudio", "initials": "C", "orcid": "0000-0003-1547-5415", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf8cf56e956942f4baa10f2772c13734.json"}}], "type": "journal article", "published": "2025-03-15", "journal": {"title": "Development", "issn": "1477-9129", "volume": "152", "issue": "6", "issn-l": "0950-1991"}, "abstract": "Gene regulators physically associate with the genome, in a combinatorial fashion, to drive tissue-specific gene expression. Uncovering the genome-wide activity of all gene regulators across tissues is therefore needed to understand gene regulation during development. Here, we take a first step towards this goal. Using CUT&RUN, we systematically mapped genome-wide binding profiles of key transcription factors and co-factors that mediate ontogenetically relevant signaling pathways in select mouse tissues at two developmental stages. Computation of the datasets unveiled tissue- and time-specific activity for each gene regulator. We identified 'popular' regulatory regions that are bound by a multitude of regulators, which tend to be more evolutionarily conserved. Consistently, they lie near the transcription start site of genes for which dysregulation results in early embryonic lethality. Moreover, the human homologs of these regions are similarly bound by many gene regulators and are highly conserved, indicating a retained relevance for human development. This work constitutes a decisive step towards understanding how the genome is simultaneously read and used by gene regulators in a holistic fashion to drive embryonic development.", "doi": "10.1242/dev.204311", "pmid": "40013513", "labels": [], "xrefs": [{"db": "pii", "key": "367215"}], "notes": [], "created": "2026-08-20T12:38:27.004Z", "modified": "2026-08-20T12:38:27.145Z"}]}