{"entity": "researcher", "timestamp": "2026-08-20T20:58:05.404Z", "family": "Kalashnikova", "given": "\u041elga B", "initials": "\u041eB", "orcid": "0000-0002-1856-1055", "affiliations": ["Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation, St. Petersburg, Russia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6e234bc02a543cfa5fe0aace31cca64.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6e234bc02a543cfa5fe0aace31cca64"}}, "publications": [{"entity": "publication", "iuid": "048922da2a384daa953047cd1a0fa998", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998"}}, "title": "Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.", "authors": [{"family": "Visentin", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0271-7200", "researcher": {"href": 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{"family": "Ruocco", "given": "Valeria", "initials": "V"}, {"family": "Orsi", "given": "Silvia", "initials": "S", "orcid": "0009-0009-8860-5875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43396caacda04fd295d0239acccb814e.json"}}, {"family": "Cellini", "given": "Alessandro", "initials": "A"}, {"family": "Angotzi", "given": "Francesco", "initials": "F"}, {"family": "Serafin", "given": "Andrea", "initials": "A"}, {"family": "Yi", "given": "Shuhua", "initials": "S", "orcid": "0000-0002-6291-812X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/035067b80e0e4efa9edf81ffa61c8e1c.json"}}, {"family": "Eichhorst", "given": "Barbara", "initials": "B"}, {"family": "Woyach", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0002-3403-9144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f223eed5e0dc4decad48346341db0f6b.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Bortoluzzi", "given": "Stefania", "initials": "S", "orcid": "0000-0001-8240-3070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0831daa98b3b4ea980ccd20da78a22fb.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "39", "issue": "12", "pages": "2957-2967", "issn-l": "0887-6924"}, "abstract": "In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-Akt. Conversely, apoptosis-related pathways were suppressed in tCLL. While the BTK gene was upregulated, the BCL2L11 gene, coding for the pro-apoptotic protein BIM, was downregulated. Notably, patients with tCLL were characterized by a trend (p = 0.058) for a longer time to the next treatment with BTK inhibitors (BTKi) compared to those treated with a venetoclax-based (Ven-based) regimen. We underscore the adverse outcomes of tCLL, its distinct molecular features and gene expression patterns. Therefore, our data suggest that identifying tCLL could help tailor therapeutic approaches.", "doi": "10.1038/s41375-025-02755-8", "pmid": "40973766", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12634426"}, {"db": "pii", "key": "10.1038/s41375-025-02755-8"}], "notes": [], "created": "2026-08-20T08:47:27.388Z", "modified": "2026-08-20T08:47:52.757Z"}, {"entity": "publication", "iuid": "21da3bc10c124fba848c5665f16e4db7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/21da3bc10c124fba848c5665f16e4db7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/21da3bc10c124fba848c5665f16e4db7"}}, "title": "COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.", "authors": [{"family": "Chatzikonstantinou", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4105-1253", "researcher": {"href": 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{"family": "Olivieri", "given": "Jacopo", "initials": "J"}, {"family": "Orsucci", "given": "Lorella", "initials": "L"}, {"family": "Papaioannou", "given": "Maria", "initials": "M"}, {"family": "Pavlovsky", "given": "Miguel Arturo", "initials": "MA"}, {"family": "Piskunova", "given": "Inga", "initials": "I"}, {"family": "Popov", "given": "Viola Maria", "initials": "VM", "orcid": "0000-0002-1200-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c76e0ce7f5094aabba4b02d70c0fa02a.json"}}, {"family": "Quaglia", "given": "Francesca Maria", "initials": "FM", "orcid": "0000-0003-4347-3775", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d5b6e74655f741ffa2f0d112bbb4fc78.json"}}, {"family": "Quaresmini", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0993-9693", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12d35dab37ac4569bc29693ee59e7295.json"}}, {"family": "Qvist", "given": "Kristian", "initials": "K"}, {"family": "Reda", "given": "Gianluigi", "initials": "G", "orcid": "0000-0003-4687-7089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc2be38bcf024aa4a06c571c1ed7ffcf.json"}}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM", "orcid": "0000-0002-8370-5190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f66f2d62db5d49d2a7443f5e0b5d3eed.json"}}, {"family": "Ruchlemer", "given": "Rosa", "initials": "R"}, {"family": "Saghumyan", "given": "Gevorg", "initials": "G"}, {"family": "Shrestha", "given": "Amit", "initials": "A"}, {"family": "\u0160imkovi\u010d", "given": "Martin", "initials": "M"}, {"family": "\u0160pa\u010dek", "given": "Martin", "initials": "M"}, {"family": "Sportoletti", "given": "Paolo", "initials": "P"}, {"family": "Stanca", "given": "Oana", "initials": "O"}, {"family": "Stavroyianni", "given": "Niki", "initials": "N"}, {"family": "Tadmor", "given": "Tamar", "initials": "T", "orcid": "0000-0002-3435-8612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ce4288f837e475e8ad1ea911d78fa4c.json"}}, {"family": "Te Raa", "given": "Doreen", "initials": "D"}, {"family": "Tonino", "given": "Sanne H", "initials": "SH"}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Van Der Spek", "given": "Ellen", "initials": "E"}, {"family": "van Gelder", "given": "Michel", "initials": "M"}, {"family": "van Kampen", "given": "Roel", "initials": "R"}, {"family": "Varettoni", "given": "Marzia", "initials": "M"}, {"family": "Visentin", "given": "Andrea", "initials": "A"}, {"family": "Vitale", "given": "Candida", "initials": "C", "orcid": "0000-0002-2592-8724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f78e00de5d57477aa5f65785c650a158.json"}}, {"family": "Wasik-Szczepanek", "given": "Ewa", "initials": "E"}, {"family": "Wr\u00f3bel", "given": "Tomasz", "initials": "T"}, {"family": "San Segundo", "given": "Lucrecia Y\u00e1\u00f1ez", "initials": "LY"}, {"family": "Yassin", "given": "Mohamed", "initials": "M"}, {"family": "Coscia", "given": "Marta", "initials": "M"}, {"family": "Rambaldi", "given": "Alessandro", "initials": "A"}, {"family": "Montserrat", "given": "Emili", "initials": "E"}, {"family": "Fo\u00e0", "given": "Robin", "initials": "R", "orcid": "0000-0002-5021-3026", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12670d8c9f80419ebbd57a1dde9f9596.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "35", "issue": "12", "pages": "3444-3454", "issn-l": "0887-6924"}, "abstract": "Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.", "doi": "10.1038/s41375-021-01450-8", "pmid": "34725454", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8559135"}, {"db": "pii", "key": "10.1038/s41375-021-01450-8"}], "notes": [], "created": "2026-08-20T08:47:17.647Z", "modified": "2026-08-20T08:47:44.704Z"}]}