{"entity": "researcher", "timestamp": "2026-08-20T20:46:18.822Z", "family": "Sharma", "given": "Sujata", "initials": "S", "orcid": "0000-0002-7588-2939", "affiliations": ["Johnson & Johnson Innovation Medicine, Spring House, PA, 19044, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4b8ed4795a048ccaa9a92c86894c8e5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4b8ed4795a048ccaa9a92c86894c8e5"}}, "publications": [{"entity": "publication", "iuid": "5eec1dde380d409885f27ec554dc25f2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5eec1dde380d409885f27ec554dc25f2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5eec1dde380d409885f27ec554dc25f2"}}, "title": "Structural basis for the oligomerization-facilitated NLRP3 activation.", "authors": [{"family": "Yu", "given": "Xiaodi", "initials": "X", "orcid": "0000-0001-7520-0646", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98e9c08373ce4e82928442709fe2a359.json"}}, {"family": "Matico", "given": "Rosalie E", "initials": "RE"}, {"family": "Miller", "given": "Robyn", "initials": "R"}, {"family": "Chauhan", "given": "Dhruv", "initials": "D"}, {"family": "Van Schoubroeck", "given": "Bertrand", "initials": "B"}, {"family": "Grauwen", "given": "Karolien", "initials": "K"}, {"family": "Suarez", "given": "Javier", "initials": "J"}, {"family": "Pietrak", "given": "Beth", "initials": "B"}, {"family": "Haloi", "given": "Nandan", "initials": "N", "orcid": "0000-0003-3542-333X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a499486a86ba4df7a27d26dad6222b47.json"}}, {"family": "Yin", "given": "Yanting", "initials": "Y"}, {"family": "Tresadern", "given": "Gary John", "initials": "GJ", "orcid": "0000-0002-4801-1644", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d1510a5374e41fdae4e040627213a4c.json"}}, {"family": "Perez-Benito", "given": "Laura", "initials": "L"}, {"family": "Lindahl", "given": "Erik", "initials": "E", "orcid": "0000-0002-2734-2794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9eb30fa60f9b4b95842ac9d9f3a0eaa9.json"}}, {"family": "Bottelbergs", "given": "Astrid", "initials": "A"}, {"family": "Oehlrich", "given": "Daniel", "initials": "D"}, {"family": "Van Opdenbosch", "given": "Nina", "initials": "N"}, {"family": "Sharma", "given": "Sujata", "initials": "S", "orcid": "0000-0002-7588-2939", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4b8ed4795a048ccaa9a92c86894c8e5.json"}}], "type": "journal article", "published": "2024-02-07", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "1164", "issn-l": "2041-1723"}, "abstract": "The NACHT-, leucine-rich-repeat-, and pyrin domain-containing protein 3 (NLRP3) is a critical intracellular inflammasome sensor and an important clinical target against inflammation-driven human diseases. Recent studies have elucidated its transition from a closed cage to an activated disk-like inflammasome, but the intermediate activation mechanism remains elusive. Here we report the cryo-electron microscopy structure of NLRP3, which forms an open octamer and undergoes a ~ 90\u00b0 hinge rotation at the NACHT domain. Mutations on open octamer's interfaces reduce IL-1\u03b2 signaling, highlighting its essential role in NLRP3 activation/inflammasome assembly. The centrosomal NIMA-related kinase 7 (NEK7) disrupts large NLRP3 oligomers and forms NEK7/NLRP3 monomers/dimers which is a critical step preceding the assembly of the disk-like inflammasome. These data demonstrate an oligomeric cooperative activation of NLRP3 and provide insight into its inflammasome assembly mechanism.", "doi": "10.1038/s41467-024-45396-8", "pmid": "38326375", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10850481"}, {"db": "pii", "key": "10.1038/s41467-024-45396-8"}, {"db": "PDB", "key": "8SWK"}, {"db": "PDB", "key": "8SXN"}, {"db": "PDB", "key": "8SWF"}], "notes": [], "created": "2026-08-20T08:53:06.542Z", "modified": "2026-08-20T08:53:06.767Z"}]}