{"entity": "researcher", "timestamp": "2026-08-20T20:39:17.291Z", "family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "affiliations": ["Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.", "SciLifeLab, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6"}}, "publications": [{"entity": "publication", "iuid": "2d9110b0c8b04668b2246bf7842ab3fb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2d9110b0c8b04668b2246bf7842ab3fb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2d9110b0c8b04668b2246bf7842ab3fb"}}, "title": "Pathway activation model for personalized prediction of drug synergy.", "authors": [{"family": "Trac", "given": "Quang Thinh", "initials": "QT", "orcid": "0000-0003-2429-0287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13e232680de04f55b195706785e79988.json"}}, {"family": "Huang", "given": "Yue", "initials": "Y"}, {"family": "Erkers", "given": "Tom", "initials": "T"}, {"family": "\u00d6stling", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Bohlin", "given": "Anna", "initials": "A"}, {"family": "Osterroos", "given": "Albin", "initials": "A"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}}, {"family": "Jafari", "given": "Rozbeh", "initials": "R"}, {"family": "Siavelis", "given": "Ioannis", "initials": "I"}, {"family": "Backvall", "given": "Helena", "initials": "H"}, {"family": "Kiviluoto", "given": "Santeri", "initials": "S"}, {"family": "Orre", "given": "Lukas", "initials": "L"}, {"family": "Rantalainen", "given": "Mattias", "initials": "M"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Lehmann", "given": "Soren", "initials": "S"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Pawitan", "given": "Yudi", "initials": "Y"}, {"family": "Vu", "given": "Trung Nghia", "initials": "TN", "orcid": "0000-0001-7945-5750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c68ab75cfd4458aaa0cff82a637a24b.json"}}], "type": "journal article", "published": "2025-06-03", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "13", "issn-l": "2050-084X"}, "abstract": "Targeted monotherapies for cancer often fail due to inherent or acquired drug resistance. By aiming at multiple targets simultaneously, drug combinations can produce synergistic interactions that increase drug effectiveness and reduce resistance. Computational models based on the integration of omics data have been used to identify synergistic combinations, but predicting drug synergy remains a challenge. Here, we introduce Drug synergy Interaction Prediction (DIPx), an algorithm for personalized prediction of drug synergy based on biologically motivated tumor- and drug-specific pathway activation scores (PASs). We trained and validated DIPx in the AstraZeneca-Sanger (AZS) DREAM Challenge human cell-line dataset using two separate test sets: Test Set 1 comprised the combinations already present in the training set, while Test Set 2 contained combinations absent from the training set, thus indicating the model's ability to handle novel combinations. The Spearman's correlation coefficients between predicted and observed drug synergy were 0.50 (95% CI: 0.47-0.53) in Test Set 1 and 0.26 (95% CI: 0.22-0.30) in Test Set 2, compared to 0.38 (95% CI: 0.34-0.42) and 0.18 (95% CI: 0.16-0.20), respectively, for the best performing method in the Challenge. We show evidence that higher synergy is associated with higher functional interaction between the drug targets, and this functional interaction information is captured by PAS. We illustrate the use of PAS to provide a potential biological explanation in terms of activated pathways that mediate the synergistic effects of combined drugs. In summary, DIPx can be a useful tool for personalized prediction of drug synergy and exploration of activated pathways related to the effects of combined drugs.", "doi": "10.7554/eLife.100071", "pmid": "40459126", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12133153"}, {"db": "pii", "key": "100071"}], "notes": [], "created": "2026-08-20T13:50:31.337Z", "modified": "2026-08-20T13:50:31.440Z"}, {"entity": "publication", "iuid": "bedbdb85145a450f91e298b33e22145c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bedbdb85145a450f91e298b33e22145c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bedbdb85145a450f91e298b33e22145c"}}, "title": "Pathway activation model for personalized prediction of drug synergy", "authors": [{"family": "Trac", "given": "Quang Thinh", "initials": "QT", "orcid": "0000-0003-2429-0287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13e232680de04f55b195706785e79988.json"}}, {"family": "Huang", "given": "Yue", "initials": "Y"}, {"family": "Erkers", "given": "Tom", "initials": "T"}, {"family": "\u00d6stling", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Bohlin", "given": "Anna", "initials": "A"}, {"family": "Osterroos", "given": "Albin", "initials": "A"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}}, {"family": "Jafari", "given": "Rozbeh", "initials": "R"}, {"family": "Siavelis", "given": "Ioannis", "initials": "I"}, {"family": "Backvall", "given": "Helena", "initials": "H"}, {"family": "Kiviluoto", "given": "Santeri", "initials": "S"}, {"family": "Orre", "given": "Lukas", "initials": "L"}, {"family": "Rantalainen", "given": "Mattias", "initials": "M"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Lehmann", "given": "Soren", "initials": "S"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Pawitan", "given": "Yudi", "initials": "Y"}, {"family": "Vu", "given": "Trung Nghia", "initials": "TN", "orcid": "0000-0001-7945-5750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c68ab75cfd4458aaa0cff82a637a24b.json"}}], "type": "journal-article", "published": "2025-06-03", "journal": {"issn": "2050-084X", "volume": "13", "title": "Elife", "issn-l": "2050-084X"}, "abstract": null, "doi": "10.7554/elife.100071.4", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:50:47.280Z", "modified": "2026-08-20T13:50:47.339Z"}, {"entity": "publication", "iuid": "d2d49f05d7904b3bad53fde048184fbf", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d2d49f05d7904b3bad53fde048184fbf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d2d49f05d7904b3bad53fde048184fbf"}}, "title": "Pathway activation model for personalized prediction of drug synergy", "authors": [{"family": "Trac", "given": "Quang Thinh", "initials": "QT", "orcid": "0000-0003-2429-0287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13e232680de04f55b195706785e79988.json"}}, {"family": "Huang", "given": "Yue", "initials": "Y"}, {"family": "Erkers", "given": "Tom", "initials": "T"}, {"family": "\u00d6stling", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Bohlin", "given": "Anna", "initials": "A"}, {"family": "\u00d6sterroos", "given": "Albin", "initials": "A"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": 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"initials": "Y"}, {"family": "Vu", "given": "Trung Nghia", "initials": "TN", "orcid": "0000-0001-7945-5750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c68ab75cfd4458aaa0cff82a637a24b.json"}}], "type": "posted-content", "published": "2025-05-20", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.100071.3", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:50:38.643Z", "modified": "2026-08-20T13:50:38.705Z"}, {"entity": "publication", "iuid": "2d9b1475f2a74141957ffa60c7cde513", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2d9b1475f2a74141957ffa60c7cde513.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2d9b1475f2a74141957ffa60c7cde513"}}, "title": "Pathway activation model for personalized prediction of drug synergy", "authors": [{"family": "Trac", "given": "Quang Thinh", "initials": "QT", "orcid": "0000-0003-2429-0287", 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"authors": [{"family": "Trac", "given": "Quang Thinh", "initials": "QT", "orcid": "0000-0003-2429-0287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13e232680de04f55b195706785e79988.json"}}, {"family": "Huang", "given": "Yue", "initials": "Y"}, {"family": "Erkers", "given": "Tom", "initials": "T"}, {"family": "\u00d6stling", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Bohlin", "given": "Anna", "initials": "A"}, {"family": "\u00d6sterroos", "given": "Albin", "initials": "A"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}}, {"family": "Jafari", "given": "Rozbeh", "initials": "R", "orcid": "0000-0002-3396-4709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95546f158dde40709fbfbb822a8f89c5.json"}}, {"family": "Siavelis", "given": "Ioannis", 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"initials": "A"}, {"family": "\u00d6sterroos", "given": "Albin", "initials": "A"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}}, {"family": "Jafari", "given": "Rozbeh", "initials": "R", "orcid": "0000-0002-3396-4709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95546f158dde40709fbfbb822a8f89c5.json"}}, {"family": "Siavelis", "given": "Ioannis", "initials": "I"}, {"family": "B\u00e4ckvall", "given": "Helena", "initials": "H"}, {"family": "Kiviluoto", "given": "Santeri", "initials": "S"}, {"family": "Orre", "given": "Lukas M", "initials": "LM"}, {"family": "Rantalainen", "given": "Mattias", "initials": "M"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Lehmann", "given": "S\u00f6ren", "initials": "S"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Pawitan", "given": "Yudi", "initials": "Y"}, {"family": "Vu", "given": "Trung Nghia", "initials": "TN", "orcid": "0000-0001-7945-5750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c68ab75cfd4458aaa0cff82a637a24b.json"}}], "type": "posted-content", "published": "2024-06-08", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.06.05.597583", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:55:06.724Z", "modified": "2026-08-20T10:55:06.811Z"}, {"entity": "publication", "iuid": "b14473323e934321b8443c64c0102100", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b14473323e934321b8443c64c0102100.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b14473323e934321b8443c64c0102100"}}, "title": "Delineating functional and molecular impact of ex vivo sample handling in precision medicine.", "authors": [{"family": "Struyf", "given": "Nona", "initials": "N", "orcid": "0000-0002-6975-0753", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be1087023d40465ca8133ea9845cd968.json"}}, {"family": "\u00d6sterroos", "given": "Albin", "initials": "A", "orcid": "0000-0001-8749-7299", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aafab8cd17e94d52a3cdeaf86d3acfa6.json"}}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}}, {"family": "Arnroth", "given": "Cornelia", "initials": "C"}, {"family": "James", "given": "Tojo", "initials": "T"}, {"family": "Sunandar", "given": "Stephanie", "initials": "S"}, {"family": "Mermelekas", "given": "Georgios", "initials": "G"}, {"family": "Bohlin", "given": "Anna", "initials": "A"}, {"family": "Hamberg Levedahl", "given": "Kerstin", "initials": "K"}, {"family": "Bengtz\u00e9n", "given": "Sofia", "initials": "S"}, {"family": "Jafari", "given": "Rozbeh", "initials": "R", "orcid": "0000-0002-3396-4709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95546f158dde40709fbfbb822a8f89c5.json"}}, {"family": "Orre", "given": "Lukas M", "initials": "LM", "orcid": "0000-0002-0384-1003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e290f7cb5dfd49eb93e63cb704459516.json"}}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Lehmann", "given": "S\u00f6ren", "initials": "S"}, {"family": "\u00d6stling", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Seashore-Ludlow", "given": "Brinton", "initials": "B", "orcid": "0000-0001-8658-5967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a8ea4c3fdb14de1b651d0367b0a70a4.json"}}, {"family": "Erkers", "given": "Tom", "initials": "T", "orcid": "0000-0002-2754-6287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a1539d1d6a944eb882fdb80eb450706.json"}}], "type": "journal article", "published": "2024-02-19", "journal": {"title": "NPJ Precis Oncol", "issn": "2397-768X", "volume": "8", "issue": "1", "pages": "38", "issn-l": null}, "abstract": "Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229 acute myeloid leukemia (AML) patient samples to assess the impact of sample handling on high-throughput functional drug testing, mass spectrometry-based proteomics, and flow cytometry. Our data revealed novel and previously described changes in cell phenotype and drug response dependent on sample biobanking. Specifically, myeloid cells with a CD117 (c-KIT) positive phenotype decreased after biobanking, potentially distorting cell population representations and affecting drugs targeting these cells. Additionally, highly granular AML cell numbers decreased after freezing. Secondly, protein expression levels, as well as sensitivity to drugs targeting cell proliferation, metabolism, tyrosine kinases (e.g., JAK, KIT, FLT3), and BH3 mimetics were notably affected by biobanking. Moreover, drug response profiles of paired fresh and frozen samples showed that freezing samples can lead to systematic errors in drug sensitivity scores. While a high correlation between fresh and frozen for the entire drug library was observed, freezing cells had a considerable impact at an individual level, which could influence outcomes in translational studies. Our study highlights conditions where standardization is needed to improve reproducibility, and where validation of data generated from biobanked cohorts may be particularly important.", "doi": "10.1038/s41698-024-00528-7", "pmid": "38374206", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10876937"}, {"db": "pii", "key": "10.1038/s41698-024-00528-7"}], "notes": [], "created": "2026-08-20T09:24:34.463Z", "modified": "2026-08-20T09:24:34.644Z"}, {"entity": "publication", "iuid": "e18900613386411ca6ad306c75d7d436", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e18900613386411ca6ad306c75d7d436.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e18900613386411ca6ad306c75d7d436"}}, "title": "Delineating functional and molecular impact of ex vivo sample handling in precision medicine", "authors": [{"family": "Erkers", "given": "Tom", "initials": "T"}, {"family": "Struyf", "given": "Nona", "initials": "N"}, {"family": "Arnroth", "given": "Cornelia", "initials": "C"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}}, {"family": "James", "given": "Tojo", "initials": "T"}, {"family": "Sunandar", "given": "Stephanie", "initials": "S"}, {"family": "Bohlin", "given": "Anna", "initials": "A"}, {"family": "Hamberg-Levedahl", "given": "Kerstin", "initials": "K"}, {"family": "Bengtz\u00e9n", "given": "Sofia", "initials": "S"}, {"family": "Jafari", "given": "Rozbeh", "initials": "R", "orcid": "0000-0002-3396-4709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95546f158dde40709fbfbb822a8f89c5.json"}}, {"family": "Orre", "given": "Lukas", "initials": "L"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Lehmann", "given": "S\u00f6ren", "initials": "S"}, {"family": "Ostling", "given": "Paivi", "initials": "P"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Seashore-Ludlow", "given": "Brinton", "initials": "B", "orcid": "0000-0001-8658-5967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a8ea4c3fdb14de1b651d0367b0a70a4.json"}}], "type": "posted-content", "published": "2023-07-26", "journal": {"issn-l": null}, "abstract": null, "doi": "10.21203/rs.3.rs-3072667/v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:59:12.192Z", "modified": "2026-08-20T12:59:12.224Z"}, {"entity": "publication", "iuid": "0982a4fafbd9457fa5129dfa54859ac3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0982a4fafbd9457fa5129dfa54859ac3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0982a4fafbd9457fa5129dfa54859ac3"}}, "title": "Proteomics identifies neddylation as a potential therapy target in small intestinal neuroendocrine tumors.", "authors": [{"family": "Fotouhi", "given": "Omid", "initials": "O"}, {"family": "Kjellin", "given": "Hanna", "initials": "H"}, {"family": "Juhlin", "given": "C Christofer", "initials": "CC", "orcid": "0000-0002-5945-9081", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c155b3a3146b41909170a016a7f5b07a.json"}}, {"family": "Pan", "given": "Yanbo", "initials": "Y"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}}, {"family": "Ghaderi", "given": "Mehran", "initials": "M"}, {"family": "Yousef", "given": "Abdelhamid", "initials": "A"}, {"family": "Andersson-Sand", "given": "Hillevi", "initials": "H"}, {"family": "Kharaziha", "given": "Pedram", "initials": "P"}, {"family": "Caramuta", "given": "Stefano", "initials": "S"}, {"family": "Kjellman", "given": "Magnus", "initials": "M"}, {"family": "Zedenius", "given": "Jan", "initials": "J"}, {"family": "Larsson", "given": "Catharina", "initials": "C"}, {"family": "Orre", "given": "Lukas M", "initials": "LM"}], "type": "journal article", "published": "2019-10-00", "journal": {"title": "Oncogene", "issn": "1476-5594", "volume": "38", "issue": "43", "pages": "6881-6897", "issn-l": "0950-9232"}, "abstract": "Patients with small intestinal neuroendocrine tumors (SI-NETs) frequently develop spread disease; however, the underlying molecular mechanisms of disease progression are not known and effective preventive treatment strategies are lacking. Here, protein expression profiling was performed by HiRIEF-LC-MS in 14 primary SI-NETs from patients with and without liver metastases detected at the time of surgery and initial treatment. Among differentially expressed proteins, overexpression of the ubiquitin-like protein NEDD8 was identified in samples from patients with liver metastasis. Further, NEDD8 correlation analysis indicated co-expression with RBX1, a key component in cullin-RING ubiquitin ligases (CRLs). In vitro inhibition of neddylation with the therapeutic agent pevonedistat (MLN4924) resulted in a dramatic decrease of proliferation in SI-NET cell lines. Subsequent mass spectrometry-based proteomics analysis of pevonedistat effects and effects of the proteasome inhibitor bortezomib revealed stabilization of multiple targets of CRLs including p27, an established tumor suppressor in SI-NET. Silencing of NEDD8 and RBX1 using siRNA resulted in a stabilization of p27, suggesting that the cellular levels of NEDD8 and RBX1 affect CRL activity. Inhibition of CRL activity, by either NEDD8/RBX1 silencing or pevonedistat treatment of cells resulted in induction of apoptosis that could be partially rescued by siRNA-based silencing of p27. Differential expression of both p27 and NEDD8 was confirmed in a second cohort of SI-NET using immunohistochemistry. Collectively, these findings suggest a role for CRLs and the ubiquitin proteasome system in suppression of p27 in SI-NET, and inhibition of neddylation as a putative therapeutic strategy in SI-NET.", "doi": "10.1038/s41388-019-0938-8", "pmid": "31406256", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41388-019-0938-8"}], "notes": [], "created": "2026-08-20T08:48:19.511Z", "modified": "2026-08-20T08:48:19.644Z"}, {"entity": "publication", "iuid": "49f3a3aead094c1d9cdc5f1db9d5f064", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/49f3a3aead094c1d9cdc5f1db9d5f064.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/49f3a3aead094c1d9cdc5f1db9d5f064"}}, "title": "Publisher Correction: Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow.", "authors": [{"family": "Zhu", "given": "Yafeng", "initials": "Y"}, {"family": "Orre", "given": "Lukas M", "initials": "LM"}, {"family": "Johansson", "given": "Henrik J", "initials": "HJ", "orcid": "0000-0003-4729-4205", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8acb3ba52a54c7a82f2a096516a8e05.json"}}, {"family": "Huss", "given": "Mikael", "initials": "M"}, {"family": "Boekel", "given": "Jorrit", "initials": "J"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M", "orcid": "0000-0001-9471-6592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e443cdb01cc44a7fa786941b5c0b62d6.json"}}, {"family": "Fernandez-Woodbridge", "given": "Alejandro", "initials": "A"}, {"family": "Branca", "given": "Rui M M", "initials": "RMM"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}], "type": "journal article", "published": "2018-05-08", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "9", "issue": "1", "pages": "1852", "issn-l": "2041-1723"}, "abstract": "In the original version of this Article, extraneous text not belonging to the Article was accidentally appended to the results section. This error has now been corrected in both the PDF and HTML versions of the Article.", "doi": "10.1038/s41467-018-04279-5", "pmid": "29739940", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5940664"}, {"db": "pii", "key": "10.1038/s41467-018-04279-5"}], "notes": [], "created": "2026-08-20T08:50:12.334Z", "modified": "2026-08-20T08:50:12.461Z"}]}