{"entity": "researcher", "timestamp": "2026-08-22T06:57:29.494Z", "family": "Hollander", "given": "Peter", "initials": "P", "orcid": "0000-0002-0226-5681", "affiliations": ["Clinical and Experimental Pathology, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e41d94e388844c40a3f467fbee197a0b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e41d94e388844c40a3f467fbee197a0b"}}, "publications": [{"entity": "publication", "iuid": "72ab1577d0f44928ae9edb64349809a1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/72ab1577d0f44928ae9edb64349809a1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/72ab1577d0f44928ae9edb64349809a1"}}, "title": "Checkpoint CD47 expression in classical Hodgkin lymphoma.", "authors": [{"family": "Gholiha", "given": "Alex Reza", "initials": "AR", "orcid": "0000-0002-3393-1106", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d47518bd66114a30a8f52de713203cf1.json"}}, {"family": "Hollander", "given": "Peter", "initials": "P", "orcid": "0000-0002-0226-5681", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e41d94e388844c40a3f467fbee197a0b.json"}}, {"family": "L\u00f6f", "given": "Liza", "initials": "L"}, {"family": "Glimelius", "given": "Ingrid", "initials": "I", "orcid": "0000-0001-6158-3041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3e9c94f8a6a45978cf6a428fb108db2.json"}}, {"family": "Hedstrom", "given": "Gustaf", "initials": "G"}, {"family": "Molin", "given": "Daniel", "initials": "D"}, {"family": "Hjalgrim", "given": "Henrik", "initials": "H"}, {"family": "Smedby", "given": "Karin E", "initials": "KE"}, {"family": "Hashemi", "given": "Jamileh", "initials": "J"}, {"family": "Amini", "given": "Rose-Marie", "initials": "RM", "orcid": "0000-0003-0901-5252", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae2f974dbafa4cdbbe268c635adcd278.json"}}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Br. J. Haematol.", "issn": "1365-2141", "volume": "197", "issue": "5", "pages": "580-589", "issn-l": "0007-1048"}, "abstract": "The glycoprotein CD47 regulates antiphagocytic activity via signal regulatory protein alpha (SIRPa). This study investigated CD47 expression on Hodgkin and Reed-Sternberg (HRS) cells in the classical Hodgkin lymphoma (cHL) tumour microenvironment and its correlation with prognosis, programmed-death (PD) immune markers, and SIRPa+ leukocytes. We conducted immunohistochemistry with CD47 and SIRPa antibodies on diagnostic biopsies (tissue microarrays) from cHL patients from two cohorts (n = 178). In cohort I (n = 136) patients with high expression of CD47 on HRS cells (n = 48) had a significantly inferior event-free survival [hazard ratio (HR) = 5.57; 95% confidence interval (CI), 2.78-11.20; p < 0.001] and overall survival (OS) (HR = 8.54; 95% CI, 3.19-22.90; p < 0.001) compared with patients with low expression (n = 88). The survival results remained statistically significant in multivariable Cox regression adjusted for known prognostic factors. In cohort II (n = 42) high HRS cell CD47 expression also carried shorter event-free survival (EFS) (HR = 5.96; 95% CI, 1.20-29.59; p = 0.029) and OS (HR = 5.61; 95% CI, 0.58-54.15; p = 0.136), although it did not retain statistical significance in the multivariable analysis. Further, high CD47 expression did not correlate with SIRPa+ leukocytes or PD-1, PD-L1 and PD-L2 expression. This study provides a deeper understanding of the role of CD47 in cHL during an era of emerging CD47 therapies.", "doi": "10.1111/bjh.18137", "pmid": "35301709", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9310712"}], "notes": [], "created": "2026-08-21T12:17:48.431Z", "modified": "2026-08-21T12:17:48.598Z"}]}