{"entity": "researcher", "timestamp": "2026-09-28T23:05:53.991Z", "family": "Mitran", "given": "Bogdan", "initials": "B", "orcid": "0000-0001-7921-3268", "affiliations": ["Division of Molecular Imaging, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e157716dab874e03a244ccbc036ce429.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e157716dab874e03a244ccbc036ce429"}}, "publications": [{"entity": "publication", "iuid": "108fd8e1db4e48639489c89b3a993f01", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/108fd8e1db4e48639489c89b3a993f01.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/108fd8e1db4e48639489c89b3a993f01"}}, "title": "High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26.", "authors": [{"family": "Mitran", "given": "Bogdan", "initials": "B", "orcid": "0000-0001-7921-3268", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e157716dab874e03a244ccbc036ce429.json"}}, {"family": "Thisgaard", "given": "Helge", "initials": "H"}, {"family": "Rosenstr\u00f6m", "given": "Ulrika", "initials": "U"}, {"family": "Dam", "given": "Johan Hygum", "initials": "JH"}, {"family": "Larhed", "given": "Mats", "initials": "M"}, {"family": "Tolmachev", "given": "Vladimir", "initials": "V", "orcid": "0000-0002-6122-1734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/896ae9fae8b74251afe11b4354c62794.json"}}, {"family": "Orlova", "given": "Anna", "initials": "A", "orcid": "0000-0001-6120-2683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c374f429702489494c05f84f298b4b7.json"}}], "type": "journal article", "published": "2017-08-10", "journal": {"title": "Contrast Media Mol Imaging", "issn": "1555-4317", "volume": "2017", "issue": null, "pages": "6873684", "issn-l": "1555-4309"}, "abstract": "High gastrin releasing peptide receptor (GRPR) expression is associated with numerous cancers including prostate and breast cancer. The aim of the current study was to develop a 55Co-labeled PET agent based on GRPR antagonist RM26 for visualization of GRPR-expressing tumors. Labeling with 57Co and 55Co, stability, binding specificity, and in vitro and in vivo characteristics of 57Co-NOTA-PEG2-RM26 were studied. NOTA-PEG2-RM26 was successfully radiolabeled with 57Co and 55Co with high yields and demonstrated high stability. The radiopeptide showed retained binding specificity to GRPR in vitro and in vivo. 57Co-NOTA-PEG2-RM26 biodistribution in mice was characterized by rapid clearance of radioactivity from blood and normal non-GRPR-expressing organs and low hepatic uptake. The clearance was predominantly renal with a low degree of radioactivity reabsorption. Tumor-to-blood ratios were approximately 200 (3 h pi) and 1000 (24 h pi). The favorable biodistribution of cobalt-labeled NOTA-PEG2-RM26 translated into high contrast preclinical PET/CT (using 55Co) and SPECT/CT (using 57Co) images of PC-3 xenografts. The initial biological results suggest that 55Co-NOTA-PEG2-RM26 is a promising tracer for PET visualization of GRPR-expressing tumors.", "doi": "10.1155/2017/6873684", "pmid": "29097932", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5612608"}], "notes": [], "created": "2018-12-05T12:28:21.308Z", "modified": "2026-09-23T10:27:09.287Z"}]}