{"entity": "researcher", "timestamp": "2026-08-20T21:22:58.749Z", "family": "Johnson", "given": "Erik C B", "initials": "ECB", "orcid": "0000-0002-0604-2944", "affiliations": ["Emory University School of Medicine, Atlanta, GA, USA.", "Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0f475a90b6a4b13a0d74e2c2cd593a5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0f475a90b6a4b13a0d74e2c2cd593a5"}}, "publications": [{"entity": "publication", "iuid": "c889c9fd45524086a24104f2fd3095a2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c889c9fd45524086a24104f2fd3095a2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c889c9fd45524086a24104f2fd3095a2"}}, "title": "The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging.", "authors": [{"family": "Imam", "given": "Farhad", "initials": "F", "orcid": "0000-0003-2854-2568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4b307d7379c43498446d995e26ef596.json"}}, {"family": "Saloner", "given": "Rowan", "initials": "R", "orcid": "0000-0002-1351-6183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23de862940594622a28cb1e1c78b4447.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Krish", "given": "Varsha", "initials": "V"}, {"family": "Abdel-Azim", "given": "Gamal", "initials": "G"}, {"family": "Ali", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-1399-6631", "researcher": {"href": 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"Vilor-Tejedor", "given": "Natalia", "initials": "N"}, {"family": "Visser", "given": "Pieter Jelle", "initials": "PJ"}, {"family": "Walker", "given": "Keenan A", "initials": "KA", "orcid": "0000-0002-5989-9853", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3c771604ad24c5b98db69b514f30592.json"}}, {"family": "Winchester", "given": "Laura M", "initials": "LM"}, {"family": "Wyss-Coray", "given": "Tony", "initials": "T", "orcid": "0000-0001-5893-0831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ad3115d413a4a46ad05465b15306b21.json"}}, {"family": "Yang", "given": "Chengran", "initials": "C", "orcid": "0000-0003-4577-5590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f11aa3f425634c9cb9bf2c30752376c5.json"}}, {"family": "Bose", "given": "Niranjan", "initials": "N", "orcid": "0000-0002-1301-7827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/03a544bbd61f48efa4ff0fc7d1578d5a.json"}}, {"family": "Lovestone", "given": "Simon", "initials": "S"}, {"family": "Global Neurodegeneration Proteomics Consortium (GNPC)", "given": "", "initials": ""}], "type": "journal article", "published": "2025-08-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "31", "issue": "8", "pages": "2556-2566", "issn-l": "1078-8956"}, "abstract": "More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due to disease heterogeneity, prolonged preclinical and prodromal phases, poor understanding of disease mechanisms, and diagnostic challenges. Identifying novel biomarkers is crucial for improving early detection, prognosis, staging and subtyping of these conditions. High-dimensional molecular studies in biofluids ('omics') offer promise for scalable biomarker discovery, but challenges in assembling large, diverse datasets hinder progress. To address this, the Global Neurodegeneration Proteomics Consortium (GNPC)-a public-private partnership-established one of the world's largest harmonized proteomic datasets. It includes approximately 250 million unique protein measurements from multiple platforms from more than 35,000 biofluid samples (plasma, serum and cerebrospinal fluid) contributed by 23 partners, alongside associated clinical data spanning Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This dataset is accessible to GNPC members via the Alzheimer's Disease Data Initiative's AD Workbench, a secure cloud-based environment, and will be available to the wider research community on 15 July 2025. Here we present summary analyses of the plasma proteome revealing disease-specific differential protein abundance and transdiagnostic proteomic signatures of clinical severity. Furthermore, we describe a robust plasma proteomic signature of APOE \u03b54 carriership, reproducible across AD, PD, FTD and ALS, as well as distinct patterns of organ aging across these conditions. This work demonstrates the power of international collaboration, data sharing and open science to accelerate discovery in neurodegeneration research.", "doi": "10.1038/s41591-025-03834-0", "pmid": "40665048", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12353841"}, {"db": "pii", "key": "10.1038/s41591-025-03834-0"}], "notes": [], "created": "2026-08-20T09:02:07.394Z", "modified": "2026-08-20T09:02:08.330Z"}, {"entity": "publication", "iuid": "cb979439e5aa4c79ba7fffcd342200cf", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cb979439e5aa4c79ba7fffcd342200cf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cb979439e5aa4c79ba7fffcd342200cf"}}, "title": "Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.", "authors": [{"family": "Saloner", "given": "Rowan", "initials": "R", "orcid": "0000-0002-1351-6183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23de862940594622a28cb1e1c78b4447.json"}}, {"family": "Staffaroni", "given": "Adam M", "initials": "AM", "orcid": "0000-0002-3903-9805", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fb13dffe3754b659cfa40e66aec0b93.json"}}, {"family": "Dammer", "given": "Eric B", "initials": "EB", "orcid": "0000-0003-2947-7606", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/173587b207be44c2a646799c4c833222.json"}}, {"family": "Johnson", "given": "Erik C B", "initials": "ECB", "orcid": "0000-0002-0604-2944", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0f475a90b6a4b13a0d74e2c2cd593a5.json"}}, {"family": "Paolillo", "given": "Emily W", "initials": "EW"}, {"family": "Wise", "given": "Amy", "initials": "A"}, {"family": "Heuer", "given": "Hilary W", "initials": "HW", "orcid": "0000-0002-3776-1685", "researcher": {"href": 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{"family": "Yokoyama", "given": "Jennifer S", "initials": "JS", "orcid": "0000-0001-7274-2634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/311301519c0448d29dd2a864358baaf5.json"}}, {"family": "Spina", "given": "Salvatore", "initials": "S", "orcid": "0000-0003-3570-9143", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88bea0e43c454afcb307564e8c3cf109.json"}}, {"family": "Grinberg", "given": "Lea T", "initials": "LT", "orcid": "0000-0002-6809-0618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0b4ccfa3c704ecf9b981049bd35719a.json"}}, {"family": "Seeley", "given": "William W", "initials": "WW", "orcid": "0000-0003-1410-2027", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0958f8776ce74a27995a79f43f257bc9.json"}}, {"family": "VandeVrede", "given": "Lawren", "initials": "L", "orcid": "0000-0002-8304-6711", "researcher": {"href": 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"Kremers", "given": "Walter", "initials": "W"}, {"family": "Lapid", "given": "Maria I", "initials": "MI", "orcid": "0000-0002-1163-5584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74d5ed7a4bbb4e67899b9923d1a2c219.json"}}, {"family": "Lee", "given": "Suzee E", "initials": "SE"}, {"family": "Litvan", "given": "Irene", "initials": "I", "orcid": "0000-0002-3485-3445", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3681bb8866844e9bbe29285f70aaadb.json"}}, {"family": "McMillan", "given": "Corey T", "initials": "CT", "orcid": "0000-0002-7581-6405", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/91e43fc35cce4333b02d6bbff648057e.json"}}, {"family": "Mendez", "given": "Mario F", "initials": "MF", "orcid": "0000-0001-6441-7989", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39dbe432437f49aaa11e5019d016b903.json"}}, {"family": "Miyagawa", "given": "Toji", "initials": "T"}, {"family": "Pantelyat", "given": "Alexander", "initials": "A", "orcid": "0000-0002-6427-7485", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa417580abf043f5abce19940013f2bd.json"}}, {"family": "Pascual", "given": "Belen", "initials": "B", "orcid": "0000-0002-4467-7406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7bff781ed18c4bbc854ee64028a3db2c.json"}}, {"family": "Masdeu", "given": "Joseph", "initials": "J"}, {"family": "Paulson", "given": "Henry L", "initials": "HL"}, {"family": "Petrucelli", "given": "Leonard", "initials": "L"}, {"family": "Pressman", "given": "Peter", "initials": "P", "orcid": "0000-0003-1760-1286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/224edc1960ad47ac85c091c96736279d.json"}}, {"family": "Rademakers", "given": "Rosa", "initials": "R"}, {"family": "Ramos", "given": "Eliana Marisa", "initials": "EM"}, {"family": "Rascovsky", "given": "Katya", "initials": "K"}, {"family": "Roberson", "given": "Erik D", "initials": "ED", "orcid": "0000-0002-1810-9763", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40883bce8ac346ce9a1af92fb3cc37ef.json"}}, {"family": "Savica", "given": "Rodolfo", "initials": "R"}, {"family": "Snyder", "given": "Allison", "initials": "A", "orcid": "0000-0002-1857-928X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78cd2d461324416fa032b6396fec0ac2.json"}}, {"family": "Sullivan", "given": "Anna Campbell", "initials": "AC"}, {"family": "Tartaglia", "given": "M Carmela", "initials": "MC", "orcid": "0000-0002-5944-8497", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c00b66ee5da4b94bdb661f4b681e443.json"}}, {"family": "Vandebergh", "given": "Marijne", "initials": "M", "orcid": "0000-0001-9645-2615", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ffdcde6e9dc84432bb26451ee3e29f02.json"}}, {"family": "Boeve", "given": "Brad F", "initials": "BF", "orcid": "0000-0002-4153-8187", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b870766e14a4775af72cf630316814b.json"}}, {"family": "Rosen", "given": "Howie J", "initials": "HJ"}, {"family": "Rojas", "given": "Julio C", "initials": "JC"}, {"family": "Boxer", "given": "Adam L", "initials": "AL"}, {"family": "Casaletto", "given": "Kaitlin B", "initials": "KB"}, {"family": "ALLFTD Consortium", "given": "", "initials": ""}], "type": "published erratum", "published": "2025-07-00", "journal": {"title": "Nat Aging", "issn": "2662-8465", "volume": "5", "issue": "7", "pages": "1372", "issn-l": null}, "abstract": null, "doi": "10.1038/s43587-025-00931-0", "pmid": "40624197", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12270897"}, {"db": "pii", "key": "10.1038/s43587-025-00931-0"}], "notes": [], "created": "2026-08-20T09:26:17.582Z", "modified": "2026-08-20T09:26:17.895Z"}, {"entity": "publication", "iuid": "a6698ce8d3bf4f6998fe40047d22152b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a6698ce8d3bf4f6998fe40047d22152b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a6698ce8d3bf4f6998fe40047d22152b"}}, "title": "Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.", "authors": [{"family": "Saloner", "given": "Rowan", "initials": "R", "orcid": "0000-0002-1351-6183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23de862940594622a28cb1e1c78b4447.json"}}, {"family": "Staffaroni", "given": "Adam M", "initials": "AM", "orcid": "0000-0002-3903-9805", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fb13dffe3754b659cfa40e66aec0b93.json"}}, {"family": "Dammer", "given": "Eric B", "initials": "EB", "orcid": "0000-0003-2947-7606", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/173587b207be44c2a646799c4c833222.json"}}, {"family": "Johnson", "given": "Erik C B", "initials": "ECB", "orcid": "0000-0002-0604-2944", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0f475a90b6a4b13a0d74e2c2cd593a5.json"}}, {"family": "Paolillo", "given": "Emily W", "initials": "EW"}, {"family": "Wise", "given": "Amy", "initials": "A"}, {"family": "Heuer", "given": "Hilary W", "initials": "HW", "orcid": "0000-0002-3776-1685", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4979afc18224dfdba4c92a8e31c7021.json"}}, {"family": "Forsberg", "given": "Leah K", "initials": "LK", "orcid": "0000-0003-4086-9598", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b39e6c71715c40e494da5b833499fcb4.json"}}, {"family": "Lario-Lago", "given": "Argentina", "initials": "A"}, {"family": "Webb", "given": "Julia D", "initials": "JD"}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Santillo", "given": "Alexander F", "initials": "AF", "orcid": "0000-0001-9717-0820", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5513ff79fb5146d385766be673d9a6ed.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Kramer", "given": "Joel H", "initials": "JH"}, {"family": "Miller", "given": "Bruce L", "initials": "BL"}, {"family": "Li", "given": "Jingyao", "initials": "J"}, {"family": "Loureiro", "given": "Joseph", "initials": "J", "orcid": "0000-0001-7222-9160", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab81f68ce2004371a738cc9d9f660377.json"}}, {"family": "Sivasankaran", "given": "Rajeev", "initials": "R", "orcid": "0000-0003-3917-0181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48e126ef85f84c18a7b4eb37b7e19183.json"}}, {"family": "Worringer", "given": "Kathleen A", "initials": "KA"}, {"family": "Seyfried", "given": "Nicholas T", "initials": "NT", "orcid": "0000-0002-4507-624X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/299b298ea1b44a30908d9acff917bfa1.json"}}, {"family": "Yokoyama", "given": "Jennifer S", "initials": "JS", "orcid": "0000-0001-7274-2634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/311301519c0448d29dd2a864358baaf5.json"}}, {"family": "Spina", "given": "Salvatore", "initials": "S", "orcid": "0000-0003-3570-9143", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88bea0e43c454afcb307564e8c3cf109.json"}}, {"family": "Grinberg", "given": "Lea T", "initials": "LT", "orcid": "0000-0002-6809-0618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0b4ccfa3c704ecf9b981049bd35719a.json"}}, {"family": "Seeley", "given": "William W", "initials": "WW", "orcid": "0000-0003-1410-2027", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0958f8776ce74a27995a79f43f257bc9.json"}}, {"family": "VandeVrede", "given": "Lawren", "initials": "L", "orcid": "0000-0002-8304-6711", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d67a6a9f2a294554bb41963033911c96.json"}}, {"family": "Ljubenkov", "given": "Peter A", "initials": "PA"}, {"family": "Bayram", "given": "Ece", "initials": "E", "orcid": "0000-0002-6875-4242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0860925521a949c09b70413a25f72ffa.json"}}, {"family": "Bozoki", "given": "Andrea", "initials": "A"}, {"family": "Brushaber", "given": "Danielle", "initials": "D", "orcid": "0009-0007-0543-0228", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73e62329a4994ce7a0679a977ce7b406.json"}}, {"family": "Considine", "given": "Ciaran M", "initials": "CM"}, {"family": "Day", "given": "Gregory S", "initials": "GS", "orcid": "0000-0001-5133-5538", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4128a4391c4b48569dc870a5b6b4a0d8.json"}}, {"family": "Dickerson", "given": "Bradford C", "initials": "BC", "orcid": "0000-0002-5958-3445", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46643f030be0486ebd9874bbfa043df7.json"}}, {"family": "Domoto-Reilly", "given": "Kimiko", "initials": "K", "orcid": "0000-0002-7396-1633", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bcbff90ec52844fa888794c1925251a7.json"}}, {"family": "Faber", "given": "Kelley", "initials": "K"}, {"family": "Galasko", "given": "Douglas R", "initials": "DR", "orcid": "0000-0001-6195-3241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/121bb3e5f79e4e39b05245941be139cd.json"}}, {"family": "Gendron", "given": "Tania", "initials": "T", "orcid": "0000-0002-7335-2627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c054dc10b1e8415e9c67eae4fdba85b6.json"}}, {"family": "Geschwind", "given": "Daniel H", "initials": "DH", "orcid": "0000-0003-2896-3450", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9558c50c9aed46339f21b1dedb588c19.json"}}, {"family": "Ghoshal", "given": "Nupur", "initials": "N", "orcid": "0000-0002-6680-6731", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c08d5ffa2d0740ada3048fe392ba42ce.json"}}, {"family": "Graff-Radford", "given": "Neill", "initials": "N"}, {"family": "Hales", "given": "Chadwick M", "initials": "CM"}, {"family": "Honig", "given": "Lawrence S", "initials": "LS", "orcid": "0000-0002-9703-2265", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0dc2515a2d34ecaabf18e8780981173.json"}}, {"family": "Hsiung", "given": "Ging-Yuek R", "initials": "GR", "orcid": "0000-0002-8017-0856", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/247a803688da4c4a8a41d6fa8a0886d1.json"}}, {"family": "Huey", "given": "Edward D", "initials": "ED"}, {"family": "Kornak", "given": "John", "initials": "J"}, {"family": "Kremers", "given": "Walter", "initials": "W"}, {"family": "Lapid", "given": "Maria I", "initials": "MI", "orcid": "0000-0002-1163-5584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74d5ed7a4bbb4e67899b9923d1a2c219.json"}}, {"family": "Lee", "given": "Suzee E", "initials": "SE"}, {"family": "Litvan", "given": "Irene", "initials": "I", "orcid": "0000-0002-3485-3445", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3681bb8866844e9bbe29285f70aaadb.json"}}, {"family": "McMillan", "given": "Corey T", "initials": "CT", "orcid": "0000-0002-7581-6405", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/91e43fc35cce4333b02d6bbff648057e.json"}}, {"family": "Mendez", "given": "Mario F", "initials": "MF", "orcid": "0000-0001-6441-7989", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39dbe432437f49aaa11e5019d016b903.json"}}, {"family": "Miyagawa", "given": "Toji", "initials": "T"}, {"family": "Pantelyat", "given": "Alexander", "initials": "A", "orcid": "0000-0002-6427-7485", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa417580abf043f5abce19940013f2bd.json"}}, {"family": "Pascual", "given": "Belen", "initials": "B", "orcid": "0000-0002-4467-7406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7bff781ed18c4bbc854ee64028a3db2c.json"}}, {"family": "Masdeu", "given": "Joseph", "initials": "J"}, {"family": "Paulson", "given": "Henry L", "initials": "HL"}, {"family": "Petrucelli", "given": "Leonard", "initials": "L"}, {"family": "Pressman", "given": "Peter", "initials": "P", "orcid": "0000-0003-1760-1286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/224edc1960ad47ac85c091c96736279d.json"}}, {"family": "Rademakers", "given": "Rosa", "initials": "R"}, {"family": "Ramos", "given": "Eliana Marisa", "initials": "EM"}, {"family": "Rascovsky", "given": "Katya", "initials": "K"}, {"family": "Roberson", "given": "Erik D", "initials": "ED", "orcid": "0000-0002-1810-9763", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40883bce8ac346ce9a1af92fb3cc37ef.json"}}, {"family": "Savica", "given": "Rodolfo", "initials": "R"}, {"family": "Snyder", "given": "Allison", "initials": "A", "orcid": "0000-0002-1857-928X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78cd2d461324416fa032b6396fec0ac2.json"}}, {"family": "Sullivan", "given": "Anna Campbell", "initials": "AC"}, {"family": "Tartaglia", "given": "M Carmela", "initials": "MC", "orcid": "0000-0002-5944-8497", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c00b66ee5da4b94bdb661f4b681e443.json"}}, {"family": "Vandebergh", "given": "Marijne", "initials": "M", "orcid": "0000-0001-9645-2615", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ffdcde6e9dc84432bb26451ee3e29f02.json"}}, {"family": "Boeve", "given": "Brad F", "initials": "BF", "orcid": "0000-0002-4153-8187", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b870766e14a4775af72cf630316814b.json"}}, {"family": "Rosen", "given": "Howie J", "initials": "HJ"}, {"family": "Rojas", "given": "Julio C", "initials": "JC"}, {"family": "Boxer", "given": "Adam L", "initials": "AL"}, {"family": "Casaletto", "given": "Kaitlin B", "initials": "KB"}, {"family": "ALLFTD Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Nat Aging", "issn": "2662-8465", "volume": "5", "issue": "6", "pages": "1143-1158", "issn-l": null}, "abstract": "The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. Here we leveraged aptamer-based proteomics (>4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations (C9orf72, GRN and MAPT) compared with 39 non-carrier controls. Network analysis identified 31 protein co-expression modules. Proteomic signatures of genetic FTLD clinical severity included increased abundance of RNA splicing (particularly in C9orf72 and GRN) and extracellular matrix (particularly in MAPT) modules, as well as decreased abundance of synaptic/neuronal and autophagy modules. The generalizability of genetic FTLD proteomic signatures was tested and confirmed in independent cohorts of (1) sporadic progressive supranuclear palsy-Richardson syndrome and (2) frontotemporal dementia spectrum clinical syndromes. Network-based proteomics hold promise for identifying replicable molecular pathways in adults living with FTLD. 'Hub' proteins driving co-expression of affected modules warrant further attention as candidate biomarkers and therapeutic targets.", "doi": "10.1038/s43587-025-00878-2", "pmid": "40380000", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12234358"}, {"db": "pii", "key": "10.1038/s43587-025-00878-2"}], "notes": [], "created": "2026-08-20T09:26:14.303Z", "modified": "2026-08-20T09:26:15.764Z"}]}