{"entity": "researcher", "timestamp": "2026-08-20T20:54:46.515Z", "family": "Temel", "given": "Sehime Gulsun", "initials": "SG", "orcid": "0000-0002-9802-0880", "affiliations": ["Department of Medical Genetics, Faculty of Medicine, Bursa Uludag University, Bursa 16059, Turkey.", "Department of Translational Medicine, Institute of Health Science, Bursa Uludag University, Bursa 16059, Turkey.", "Department of Histology and Embryology, Faculty of Medicine, Bursa Uludag University, Bursa 16059, Turkey."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/e08a9741204744e78b62958e0bf94794.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/e08a9741204744e78b62958e0bf94794"}}, "publications": [{"entity": "publication", "iuid": "a5c1bc6f1ade4bb9bbe7080fcea6a16b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a5c1bc6f1ade4bb9bbe7080fcea6a16b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a5c1bc6f1ade4bb9bbe7080fcea6a16b"}}, "title": "Unravelling the Complexity of Sarcopenia Through a Systems Biology Approach.", "authors": [{"family": "Ceyhan", "given": "Atakan Burak", "initials": "AB", "orcid": "0009-0004-7279-7482", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7b1d40cd1ec4d4aa75f133db6d2ff1a.json"}}, {"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Zhang", "given": "Cheng", "initials": "C", "orcid": "0000-0002-3721-8586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46e4161be08458994efddb75ed75874.json"}}, {"family": "Temel", "given": "Sehime Gulsun", "initials": "SG", "orcid": "0000-0002-9802-0880", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e08a9741204744e78b62958e0bf94794.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2025-09-02", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "26", "issue": "17", "issn-l": null}, "abstract": "Sarcopenia, a significant loss of muscle mass and strength, is an important healthcare problem in the geriatric population. While age-related muscle decline represents the most common form, sarcopenia may also develop as a secondary condition associated with chronic diseases, including cancer, diabetes, chronic obstructive pulmonary disease, and autoimmune disorders. It increases frailty, disability, and fall risk among the elderly while also raising hospitalization rates and associated healthcare costs. Although no pharmaceutical agents have been specifically approved for the treatment of sarcopenia to date, elucidating its underlying molecular mechanisms of sarcopenia through systems biology approaches is essential for the development of novel therapeutic strategies and preventive interventions. This review examines the current definitions of sarcopenia, recent advancements in its management, and the emerging role of systems biology in uncovering potential biomarkers and therapeutic targets. We discuss how these approaches may contribute to the development of novel interventions aimed at enhancing muscle health and improving the quality of life in older adults and provide a summary of the current progress achieved through systems biology methodologies in sarcopenia research.", "doi": "10.3390/ijms26178527", "pmid": "40943447", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12428996"}, {"db": "pii", "key": "ijms26178527"}], "notes": [], "created": "2026-08-20T13:42:00.420Z", "modified": "2026-08-20T13:42:00.527Z"}, {"entity": "publication", "iuid": "35ef6915c3e84674815a2bc5d9f9e404", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/35ef6915c3e84674815a2bc5d9f9e404.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/35ef6915c3e84674815a2bc5d9f9e404"}}, "title": "Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention.", "authors": [{"family": "Ceyhan", "given": "Atakan Burak", "initials": "AB", "orcid": "0009-0004-7279-7482", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7b1d40cd1ec4d4aa75f133db6d2ff1a.json"}}, {"family": "Kaynar", "given": "Ali", "initials": "A", "orcid": "0000-0002-8507-744X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/afaea854b1ad44ec8c6efc6323f516cd.json"}}, {"family": "Altay", "given": "Ozlem", "initials": "O"}, {"family": "Zhang", "given": "Cheng", "initials": "C", "orcid": "0000-0002-3721-8586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46e4161be08458994efddb75ed75874.json"}}, {"family": "Temel", "given": "Sehime Gulsun", "initials": "SG", "orcid": "0000-0002-9802-0880", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e08a9741204744e78b62958e0bf94794.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2024-10-29", "journal": {"title": "Biomolecules", "issn": "2218-273X", "volume": "14", "issue": "11", "issn-l": null}, "abstract": "Collagen VI-related dystrophies (COL6RD) are a group of rare muscle disorders caused by mutations in specific genes responsible for type VI collagen production. It affects muscles, joints, and connective tissues, leading to weakness, joint problems, and structural issues. Currently, there is no effective treatment for COL6RD; its management typically addresses symptoms and complications. Therefore, it is essential to decipher the disease's molecular mechanisms, identify drug targets, and develop effective treatment strategies to treat COL6RD. In this study, we employed differential gene expression analysis, weighted gene co-expression network analysis, and genome-scale metabolic modeling to investigate gene expression patterns in COL6RD patients, uncovering key genes, significant metabolites, and disease-related pathophysiological pathways. First, we performed differential gene expression and weighted gene co-expression network analyses, which led to the identification of 12 genes (CHCHD10, MRPS24, TRIP10, RNF123, MRPS15, NDUFB4, COX10, FUNDC2, MDH2, RPL3L, NDUFB11, PARVB) as potential hub genes involved in the disease. Second, we utilized a drug repurposing strategy to identify pharmaceutical candidates that could potentially modulate these genes and be effective in the treatment. Next, we utilized context-specific genome-scale metabolic models to compare metabolic variations between healthy individuals and COL6RD patients. Finally, we conducted reporter metabolite analysis to identify reporter metabolites (e.g., phosphatidates, nicotinate ribonucleotide, ubiquinol, ferricytochrome C). In summary, our analysis revealed critical genes and pathways associated with COL6RD and identified potential targets, reporter metabolites, and candidate drugs for therapeutic interventions.", "doi": "10.3390/biom14111376", "pmid": "39595553", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11592009"}, {"db": "pii", "key": "biom14111376"}, {"db": "GEO", "key": "GSE103608"}], "notes": [], "created": "2026-08-20T13:38:48.538Z", "modified": "2026-08-20T13:38:48.796Z"}]}