{"entity": "researcher", "timestamp": "2026-09-23T20:28:12.394Z", "family": "Wiedmann", "given": "Mareike M", "initials": "MM", "orcid": "0000-0002-4728-7155", "affiliations": ["Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.", "Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfcca5223c844cbc8a266dfcc8fde87e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfcca5223c844cbc8a266dfcc8fde87e"}}, "publications": [{"entity": "publication", "iuid": "74a47014d1e44696885710e94e12fa97", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/74a47014d1e44696885710e94e12fa97.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/74a47014d1e44696885710e94e12fa97"}}, "title": "Development of Cell\u2010Permeable, Non\u2010Helical Constrained Peptides to Target a Key Protein\u2013Protein Interaction in Ovarian Cancer", "authors": [{"family": "Wiedmann", "given": "Mareike M", "initials": "MM", "orcid": "0000-0002-4728-7155", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfcca5223c844cbc8a266dfcc8fde87e.json"}}, {"family": "Tan", "given": "Yaw Sing", "initials": "YS", "orcid": "0000-0002-2522-9421", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ac8480acb7a4ab8b6410f69f5197da5.json"}}, {"family": "Wu", "given": "Yuteng", "initials": "Y"}, {"family": "Aibara", "given": "Shintaro", "initials": "S", "orcid": "0000-0003-2221-482X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b56490b2c675425dbe8008c0d50e38bb.json"}}, {"family": "Xu", "given": "Wenshu", "initials": "W"}, {"family": "Sore", "given": "Hannah F", "initials": "HF", "orcid": "0000-0002-6542-0394", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37e25a723e2b41a38e774739e162bf01.json"}}, {"family": "Verma", "given": "Chandra S", "initials": "CS"}, {"family": "Itzhaki", "given": "Laura", "initials": "L", "orcid": "0000-0001-6504-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27e1058398ec4db6bb33d2d6988ccea1.json"}}, {"family": "Stewart", "given": "Murray", "initials": "M"}, {"family": "Brenton", "given": "James D", "initials": "JD", "orcid": "0000-0002-5738-6683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2885ff10958144a08952cb0795987f55.json"}}, {"family": "Spring", "given": "David R", "initials": "DR", "orcid": "0000-0001-7355-2824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ff6443b645d4033b5e30eb753bb16c3.json"}}], "type": "journal-article", "published": "2017-01-09", "journal": {"title": "Angewandte Chemie", "issn": "0044-8249", "volume": "129", "issue": "2", "pages": "539-544", "issn-l": null}, "abstract": null, "doi": "10.1002/ange.201609427", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T12:19:59.927Z", "modified": "2026-09-23T12:20:00.044Z"}, {"entity": "publication", "iuid": "bf77d58749914090847e6df234838ff1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf77d58749914090847e6df234838ff1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf77d58749914090847e6df234838ff1"}}, "title": "Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.", "authors": [{"family": "Wiedmann", "given": "Mareike M", "initials": "MM", "orcid": "0000-0002-4728-7155", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfcca5223c844cbc8a266dfcc8fde87e.json"}}, {"family": "Tan", "given": "Yaw Sing", "initials": "YS", "orcid": "0000-0002-2522-9421", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ac8480acb7a4ab8b6410f69f5197da5.json"}}, {"family": "Wu", "given": "Yuteng", "initials": "Y"}, {"family": "Aibara", "given": "Shintaro", "initials": "S", "orcid": "0000-0003-2221-482X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b56490b2c675425dbe8008c0d50e38bb.json"}}, {"family": "Xu", "given": "Wenshu", "initials": "W"}, {"family": "Sore", "given": "Hannah F", "initials": "HF", "orcid": "0000-0002-6542-0394", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37e25a723e2b41a38e774739e162bf01.json"}}, {"family": "Verma", "given": "Chandra S", "initials": "CS"}, {"family": "Itzhaki", "given": "Laura", "initials": "L", "orcid": "0000-0001-6504-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27e1058398ec4db6bb33d2d6988ccea1.json"}}, {"family": "Stewart", "given": "Murray", "initials": "M"}, {"family": "Brenton", "given": "James D", "initials": "JD", "orcid": "0000-0002-5738-6683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2885ff10958144a08952cb0795987f55.json"}}, {"family": "Spring", "given": "David R", "initials": "DR", "orcid": "0000-0001-7355-2824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ff6443b645d4033b5e30eb753bb16c3.json"}}], "type": "journal article", "published": "2017-01-09", "journal": {"title": "Angew. Chem. Int. Ed. Engl.", "issn": "1521-3773", "volume": "56", "issue": "2", "pages": "524-529", "issn-l": "1433-7851"}, "abstract": "There is a lack of current treatment options for ovarian clear cell carcinoma (CCC) and the cancer is often resistant to platinum-based chemotherapy. Hence there is an urgent need for novel therapeutics. The transcription factor hepatocyte nuclear factor 1\u03b2 (HNF1\u03b2) is ubiquitously overexpressed in CCC and is seen as an attractive therapeutic target. This was validated through shRNA-mediated knockdown of the target protein, HNF1\u03b2, in five high- and low-HNF1\u03b2-expressing CCC lines. To inhibit the protein function, cell-permeable, non-helical constrained proteomimetics to target the HNF1\u03b2-importin \u03b1 protein-protein interaction were designed, guided by X-ray crystallographic data and molecular dynamics simulations. In this way, we developed the first reported series of constrained peptide nuclear import inhibitors. Importantly, this general approach may be extended to other transcription factors.", "doi": "10.1002/anie.201609427", "pmid": "27918136", "labels": [], "xrefs": [{"db": "mid", "key": "EMS71208"}, {"db": "pmc", "key": "PMC5291322"}], "notes": [], "created": "2018-12-05T11:05:09.969Z", "modified": "2026-09-23T09:30:00.281Z"}]}