{"entity": "researcher", "timestamp": "2026-08-22T08:32:14.258Z", "family": "Goodwin", "given": "Richard J A", "initials": "RJA", "orcid": "0000-0001-5699-8488", "affiliations": ["Integrated BioAnalysis, Clinical Pharmacology & Safety Sciences R&D, AstraZeneca, Cambridge, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/debf1fe0756d4ad986bf74605fce924c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/debf1fe0756d4ad986bf74605fce924c"}}, "publications": [{"entity": "publication", "iuid": "b37236fffb8c4610aba116ecc92e9237", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b37236fffb8c4610aba116ecc92e9237.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b37236fffb8c4610aba116ecc92e9237"}}, "title": "Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism.", "authors": [{"family": "Tsyben", "given": "Anastasia", "initials": "A"}, {"family": "Dannhorn", "given": "Andreas", "initials": "A", "orcid": "0000-0002-1087-4057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/842705f631e44ff1bbdcacfc24505168.json"}}, {"family": "Hamm", "given": "Gregory", "initials": "G"}, {"family": "Pitoulias", "given": "Manthos", "initials": "M", "orcid": "0000-0002-9814-0604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af378ed23da047c4af0a89acefd13be2.json"}}, {"family": "Couturier", "given": "Dominique-Laurent", "initials": "DL"}, {"family": "Sawle", "given": "Ashley", "initials": "A", "orcid": "0000-0002-2985-5059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49b12d4d6eb64049859be60ff93d4b9b.json"}}, {"family": "Briggs", "given": "Mayen", "initials": "M"}, {"family": "Wright", "given": "Alan J", "initials": "AJ", "orcid": "0000-0002-4577-5681", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4857ef1438f54373ba70b8715670046d.json"}}, {"family": "Brodie", "given": "Cara", "initials": "C"}, {"family": "Mendil", "given": "Lee", "initials": "L"}, {"family": "Miller", "given": "Jodi L", "initials": "JL", "orcid": "0000-0001-6870-204X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/431fdbdd2eb44e648e2a8424c3d5605d.json"}}, {"family": "Williams", "given": "Eleanor C", "initials": "EC", "orcid": "0000-0002-8023-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dca992134b6f45e9b6e547394eff3be0.json"}}, {"family": "Franz\u00e9n", "given": "Lovisa", "initials": "L"}, {"family": "De Jong", "given": "Grand", "initials": "G"}, {"family": "Gracia", "given": "Tannia", "initials": "T"}, {"family": "Memi", "given": "Fani", "initials": "F"}, {"family": "Bayraktar", "given": "Omer Ali", "initials": "OA", "orcid": "0000-0001-6055-277X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c33c0dfa62cc46318b16be449da80e31.json"}}, {"family": "Adapa", "given": "Ram", "initials": "R"}, {"family": "Rao", "given": "Jyotsna", "initials": "J"}, {"family": "Gonz\u00e1lez-Fern\u00e1ndez", "given": "Ariadna", "initials": "A", "orcid": "0009-0003-3225-4718", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fbe7742e71c41cfa1106806fbfeed32.json"}}, {"family": "CRUK Rosetta Grand Challenge Consortium", "given": "", "initials": ""}, {"family": "Bunch", "given": "Josephine", "initials": "J"}, {"family": "Takats", "given": "Zoltan", "initials": "Z", "orcid": "0000-0002-0795-3467", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7f7a02c9df641a9bc21ffbeca989d47.json"}}, {"family": "Barry", "given": "Simon T", "initials": "ST", "orcid": "0000-0002-8511-0588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ee3cf5ee34c4900ad6da410a60cc963.json"}}, {"family": "Goodwin", "given": "Richard J A", "initials": "RJA", "orcid": "0000-0001-5699-8488", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/debf1fe0756d4ad986bf74605fce924c.json"}}, {"family": "Mair", "given": "Richard", "initials": "R", "orcid": "0000-0001-8235-5689", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9286c35223934d9b8bf39354aca38f4f.json"}}, {"family": "Brindle", "given": "Kevin M", "initials": "KM", "orcid": "0000-0003-3883-6287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ea6bbe130b04e3cb8b580c1b00d5f20.json"}}], "type": "journal article", "published": "2025-05-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "7", "issue": "5", "pages": "928-939", "issn-l": "2522-5812"}, "abstract": "Transcriptomic studies have attempted to classify glioblastoma (GB) into subtypes that predict survival and have different therapeutic vulnerabilities1-3. Here we identified three metabolic subtypes: glycolytic, oxidative and a mix of glycolytic and oxidative, using mass spectrometry imaging of rapidly excised tumour sections from two patients with GB who were infused with [U-13C]glucose and from spatial transcriptomic analysis of contiguous sections. The phenotypes are not correlated with microenvironmental features, including proliferation rate, immune cell infiltration and vascularization, are retained when patient-derived cells are grown in vitro or as orthotopically implanted xenografts and are robust to changes in oxygen concentration, demonstrating their cell-intrinsic nature. The spatial extent of the regions occupied by cells displaying these distinct metabolic phenotypes is large enough to be detected using clinically applicable metabolic imaging techniques. A limitation of the study is that it is based on only two patient tumours, albeit on multiple sections, and therefore represents a proof-of-concept study.", "doi": "10.1038/s42255-025-01293-y", "pmid": "40389678", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12116388"}, {"db": "pii", "key": "10.1038/s42255-025-01293-y"}], "notes": [], "created": "2026-08-21T11:54:49.268Z", "modified": "2026-08-21T11:54:49.706Z"}]}