{"entity": "researcher", "timestamp": "2026-09-26T00:51:19.317Z", "family": "Benhsaien", "given": "Ibtihal", "initials": "I", "orcid": "0000-0001-5727-9629", "affiliations": ["Department of Pediatric Infectious and Immunological Diseases, Children's Hospital, Averroes University Hospital, Casablanca, Morocco.", "Laboratory of Clinical Immunology, Inflammation, and Allergy, Faculty of Medicine and Pharmacy of Casablanca, King Hassan II University, Casablanca, Morocco."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/de7f4debd8f54f91b8c3482e487ac9f4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/de7f4debd8f54f91b8c3482e487ac9f4"}}, "publications": [{"entity": "publication", "iuid": "c57b92d9ab5a4c30bb0cfd010927f6cc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c57b92d9ab5a4c30bb0cfd010927f6cc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c57b92d9ab5a4c30bb0cfd010927f6cc"}}, "title": "Human LY9 governs CD4+ T cell IFN-\u03b3 immunity to Mycobacterium tuberculosis.", "authors": [{"family": "Ogishi", "given": "Masato", "initials": "M", "orcid": "0000-0003-2421-7389", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6bb721a88454fdab61a383d7953ef43.json"}}, {"family": "Puchan", "given": "Julia", "initials": "J", "orcid": "0000-0003-0284-3629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbd467c5c42f42ef9657aa8d71f974cd.json"}}, {"family": "Yang", "given": "Rui", "initials": "R", "orcid": "0000-0003-4427-2158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c02fa86224bd40e2abc556c54530b8ae.json"}}, {"family": "Arias", "given": "Andr\u00e9s Augusto", "initials": "AA"}, {"family": "Han", "given": "Ji Eun", "initials": "JE", "orcid": "0000-0003-1112-9320", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/005b5dcb870142198103352b248766ba.json"}}, {"family": "Nguyen", "given": "Tina", "initials": "T", "orcid": "0000-0003-0709-3636", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/508a75730e904769b796c74fc7bd918f.json"}}, {"family": "Guti\u00e9rrez-C\u00f3zar", "given": "Rebeca", "initials": "R", "orcid": "0000-0003-0348-3223", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/770c8296d76048c184f5618b12372071.json"}}, {"family": "Conil", "given": "Cl\u00e9ment", "initials": "C"}, {"family": "Seeleuthner", "given": "Yoann", "initials": "Y"}, {"family": "Rinchai", "given": "Darawan", "initials": "D", "orcid": "0000-0001-8851-7730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec2d8fcc17fb408f8b1bf74da93d83b5.json"}}, {"family": "Zhang", "given": "Peng", "initials": "P", "orcid": "0000-0002-6129-567X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1738147a99b94d51831307e8c94b4d39.json"}}, {"family": "Ponsin", "given": "Khoren", "initials": "K"}, {"family": "Chaldebas", "given": "Matthieu", "initials": "M", "orcid": "0000-0002-4920-3947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9838045e114a4ebe945babdc8e4fb51a.json"}}, {"family": "Feng", "given": "Yi", "initials": "Y", "orcid": "0000-0002-2393-1700", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc4f3cc37e224ae0a533059f5dd3084c.json"}}, {"family": "Neehus", "given": "Anna-Lena", "initials": "AL", "orcid": "0000-0002-8573-6820", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d784d3e436144938013c4b2e665f8bd.json"}}, {"family": "Delmonte", "given": "Ottavia M", "initials": "OM", "orcid": "0000-0002-4772-0799", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b43eba3fcbc045a3ae9d4a643c1dbb8e.json"}}, {"family": "Khan", "given": "Taushif", "initials": "T", "orcid": "0000-0002-7917-8965", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccdb92802adf4cd3ad450457d55f0681.json"}}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Bohlen", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0458-9484", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/148365cb4ce84786a90e0e67be49cc29.json"}}, {"family": "Peel", "given": "Jessica N", "initials": "JN"}, {"family": "Fagniez", "given": "Iris", "initials": "I", "orcid": "0009-0009-9900-3001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a80c8b1aaf944dbe818cc9e604fb2dd2.json"}}, {"family": "Pelham", "given": "Simon J", "initials": "SJ", "orcid": "0000-0002-3119-662X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6bbfe4d9323146fcba0c02cef20210ff.json"}}, {"family": "Lei", "given": "Wei-Te", "initials": "WT", "orcid": "0000-0003-1677-8901", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd8eb945ba104635ab6adfc254f1947d.json"}}, {"family": "Chrabieh", "given": "Maya", "initials": "M"}, {"family": "Laine", "given": "Candice", "initials": "C", "orcid": "0000-0003-3258-6969", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae69cfc940a24e58b21c2904d8b8c8e6.json"}}, {"family": "Ouair", "given": "Hind", "initials": "H"}, {"family": "Benhsaien", "given": "Ibtihal", "initials": "I", "orcid": "0000-0001-5727-9629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de7f4debd8f54f91b8c3482e487ac9f4.json"}}, {"family": "Abid", "given": "Ahmed", "initials": "A", "orcid": "0000-0003-4885-6572", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/91507e0b2f8a4c428a38f41b739e0e8e.json"}}, {"family": "Abderrhamani Ghorfi", "given": "Ismail", "initials": "I", "orcid": "0000-0001-6403-0098", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a55e3dd21ba43b98124522c4f124730.json"}}, {"family": "Souhi", "given": "Hicham", "initials": "H", "orcid": "0000-0003-3183-1627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4da8963a7c1e4ea8b5d053b9da72ff83.json"}}, {"family": "Ouazzani", "given": "Hanane", "initials": "H"}, {"family": "Aniss", "given": "Rafik", "initials": "R"}, {"family": "Riminton", "given": "D Sean", "initials": "DS", "orcid": "0000-0002-9953-9959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bcdbd34e36f049dba61ca4d972bdceaa.json"}}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}, {"family": "Turvey", "given": "Stuart E", "initials": "SE", "orcid": "0000-0003-1599-1065", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff959093c3ad4dec9ab07d77df55fca2.json"}}, {"family": "Marr", "given": "Nico", "initials": "N", "orcid": "0000-0002-1927-7072", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/873bf845d7cc4f60b89890daeb8c3682.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c24b272de580450caee36c6e772b6bc6.json"}}, {"family": "Hatipoglu", "given": "Nevin", "initials": "N", "orcid": "0000-0003-2858-0150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb6b85b3f4ab45e09dd953c7453cd543.json"}}, {"family": "Bousfiha", "given": "Aziz", "initials": "A", "orcid": "0000-0002-5011-9873", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a5a39701b5b49e9ac00954d39583fec.json"}}, {"family": "Ozcelik", "given": "Tayfun", "initials": "T", "orcid": "0000-0001-5937-1082", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eda5f77bb3414cda84fd38e5453853b9.json"}}, {"family": "El Baghdadi", "given": "Jamila", "initials": "J", "orcid": "0000-0002-1920-2310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65bd30a7e2174e9f83f390439bdbedb7.json"}}, {"family": "Cobat", "given": "Aurelie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55186a4757e7417389f415061b59ab5c.json"}}, {"family": "Ma", "given": "Cindy S", "initials": "CS", "orcid": "0000-0001-5387-8413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3228c36af6cd409c8b764481adfd1e44.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80da2e422a014973a981c891c6c38070.json"}}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d106604b8ad84e67870302b906a94963.json"}}, {"family": "Bustamante", "given": "Jacinta", "initials": "J", "orcid": "0000-0002-3439-2482", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa1b61228ab64930a29bc9fe49a40138.json"}}, {"family": "Engel", "given": "Pablo", "initials": "P", "orcid": "0000-0001-8410-252X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a322e1167b07477b939dcee4c31d1145.json"}}, {"family": "Gros", "given": "Philippe", "initials": "P", "orcid": "0000-0002-0114-1978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6b9fec5864e4ba487d4428b2fb6635f.json"}}, {"family": "Tangye", "given": "Stuart G", "initials": "SG", "orcid": "0000-0002-5360-5180", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/912fd6d21daf4445954130fe263adcba.json"}}, {"family": "Sallusto", "given": "Federica", "initials": "F", "orcid": "0000-0003-3750-2752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7039a50311b0479cac1e45de31c8557f.json"}}, {"family": "Boisson-Dupuis", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-7115-116X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8065ab07cf1144fdb155c983e905869e.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/264335517ad94440b23a027fe66f767d.json"}}], "type": "journal article", "published": "2025-05-30", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "10", "issue": "107", "pages": "eads7377", "issn-l": "2470-9468"}, "abstract": "CD4+ T cells are indispensable for optimal immunity to Mycobacterium tuberculosis (M.tb), a pathogen that triggers tuberculosis (TB) in humans. M.tb-specific human CD4+ T cells are known to polarize toward an interferon-\u03b3 (IFN-\u03b3)-producing, CCR4-CCR6+CXCR3+T-bet+ROR\u03b3T+ T helper 1* cell (TH1*cell) memory phenotype. We report that autosomal recessive deficiency of the human lymphocytic surface receptor LY9 (SLAMF3 and CD229), which is found in less than 10-5 individuals in the general population, underlies TB in three unrelated patients due to selective impairment in IFN-\u03b3 production by TH1* cells. TH1* cells express higher levels of LY9 than other CD4+ T cells. Mechanistically, LY9 polarizes na\u00efve CD4+ T cells toward memory TH1* cells by inducing T-bet via signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) and ROR\u03b3T (thymus-specific retinoid-related orphan receptor \u03b3) without SAP. LY9 costimulation enhances TCR-driven IFN-\u03b3 production of memory TH1*, but not TH1, cells in a T cell-intrinsic manner via NFAT1 (nuclear factor of activated T cells 1) and ROR\u03b3T. LY9 is likely to govern an optimal TH1* cell- and IFN-\u03b3-dependent protective immunity to M.tb in humans.", "doi": "10.1126/sciimmunol.ads7377", "pmid": "40446017", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS2092213"}, {"db": "pmc", "key": "PMC12242830"}], "notes": [], "created": "2026-09-23T09:11:27.763Z", "modified": "2026-09-23T09:11:29.293Z"}]}