{"entity": "researcher", "timestamp": "2026-09-23T14:45:44.753Z", "family": "von Seth", "given": "Johanna", "initials": "J", "orcid": "0000-0002-1324-7489", "affiliations": ["Centre for Palaeogenetics, Stockholm, Sweden. johanna.n.vonseth@gmail.com.", "Department of Bioinformatics and Genetics, Swedish Museum of Natural History, Stockholm, Sweden. johanna.n.vonseth@gmail.com.", "Department of Zoology, Stockholm University, Stockholm, Sweden. johanna.n.vonseth@gmail.com."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd70195ca85f415caf1e4660681e1bbc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd70195ca85f415caf1e4660681e1bbc"}}, "publications": [{"entity": "publication", "iuid": "5bc0a14063dd428abcdf011a3eeac8b9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5bc0a14063dd428abcdf011a3eeac8b9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5bc0a14063dd428abcdf011a3eeac8b9"}}, "title": "Temporal genomic change in the Scandinavian Arctic fox (Vulpes lagopus)", "authors": [{"family": "von Seth", "given": "Johanna", "initials": "J", "orcid": "0000-0002-1324-7489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd70195ca85f415caf1e4660681e1bbc.json"}}, {"family": "Larsson", "given": "Petter", "initials": "P"}, {"family": "Hasselgren", "given": "Malin", "initials": "M"}, {"family": "Dussex", "given": "Nicolas", "initials": "N"}, {"family": "Farelo", "given": "Liliana", "initials": "L"}, {"family": "Wall\u00e9n", "given": "Johan", "initials": "J"}, {"family": "Kutschera", "given": "Verena E", "initials": "VE"}, {"family": "Eide", "given": "Nina E", "initials": "NE"}, {"family": "Landa", "given": "Arild", "initials": "A"}, {"family": "Angerbj\u00f6rn", "given": "Anders", "initials": "A"}, {"family": "Flagstad", "given": "\u00d8ystein", "initials": "\u00d8"}, {"family": "Melo-Ferreira", "given": "Jos\u00e9", "initials": "J", "orcid": "0000-0003-4473-1908", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0e8294f10334ab2a152fb70a3ef8698.json"}}, {"family": "Nor\u00e9n", "given": "Karin", "initials": "K"}, {"family": "Dal\u00e9n", "given": "Love", "initials": "L"}], "type": "journal-article", "published": "2025-08-01", "journal": {"issn": "0024-4082", "volume": "204", "issue": "4", "issn-l": null}, "abstract": null, "doi": "10.1093/zoolinnean/zlaf078", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T13:19:08.045Z", "modified": "2026-09-23T13:19:08.094Z"}, {"entity": "publication", "iuid": "e920c1f22cda45779093650b3ba351c7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e920c1f22cda45779093650b3ba351c7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e920c1f22cda45779093650b3ba351c7"}}, "title": "Genomic and fitness consequences of inbreeding in an endangered carnivore.", "authors": [{"family": "Hasselgren", "given": "Malin", "initials": "M", "orcid": "0000-0002-4875-4413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8edda52bf4624a85b7ff12c73df96005.json"}}, {"family": "Dussex", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-9179-8593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c93917b1e544c6eae92fd4aa0617fd8.json"}}, {"family": "von Seth", "given": "Johanna", "initials": "J", "orcid": "0000-0002-1324-7489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd70195ca85f415caf1e4660681e1bbc.json"}}, {"family": "Angerbj\u00f6rn", "given": "Anders", "initials": "A"}, {"family": "Olsen", "given": "Remi-Andr\u00e9", "initials": "RA"}, {"family": "Dal\u00e9n", "given": "Love", "initials": "L"}, {"family": "Nor\u00e9n", "given": "Karin", "initials": "K", "orcid": "0000-0002-9707-5206", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d9f4f7f4e8e4854af25af5fee946ce4.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Mol. Ecol.", "issn": "1365-294X", "volume": "30", "issue": "12", "pages": "2790-2799", "issn-l": "0962-1083"}, "abstract": "Reduced fitness through genetic drift and inbreeding is a major threat to small and isolated populations. Although previous studies have generally used genetically verified pedigrees to document effects of inbreeding and gene flow, these often fail to capture the whole inbreeding history of the species. By assembling a draft arctic fox (Vulpes lagopus) genome and resequencing complete genomes of 23 additional foxes born before and after a well-documented immigration event in Scandinavia, we here look into the genomic consequences of inbreeding and genetic rescue. We found a difference in genome-wide diversity, with 18% higher heterozygosity and 81% lower FROH in immigrant F1 compared to native individuals. However, more distant descendants of immigrants (F2, F3) did not show the same pattern. We also found that foxes with lower inbreeding had higher probability to survive their first year of life. Our results demonstrate the important link between genetic variation and fitness as well as the transient nature of genetic rescue. Moreover, our results have implications in conservation biology as they demonstrate that inbreeding depression can effectively be detected in the wild by a genomic approach.", "doi": "10.1111/mec.15943", "pmid": "33955096", "labels": [], "xrefs": [{"db": "Dryad", "key": "10.5061/dryad.gmsbcc2mn"}], "notes": [], "created": "2026-09-23T09:33:05.582Z", "modified": "2026-09-23T09:33:05.668Z"}, {"entity": "publication", "iuid": "8a1ca3a7300f487581f5b89098c107d0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8a1ca3a7300f487581f5b89098c107d0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8a1ca3a7300f487581f5b89098c107d0"}}, "title": "Genomic insights into the conservation status of the world's last remaining Sumatran rhinoceros populations.", "authors": [{"family": "von Seth", "given": "Johanna", "initials": "J", "orcid": "0000-0002-1324-7489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd70195ca85f415caf1e4660681e1bbc.json"}}, {"family": "Dussex", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-9179-8593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c93917b1e544c6eae92fd4aa0617fd8.json"}}, {"family": "D\u00edez-Del-Molino", "given": "David", "initials": "D", "orcid": "0000-0002-9701-5940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ffd5992faedc45e1bfe19fd498485400.json"}}, {"family": "van der Valk", "given": "Tom", "initials": "T", "orcid": "0000-0001-6582-3452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa0dba3cc12143cba213f7f3a052216c.json"}}, {"family": "Kutschera", "given": "Verena E", "initials": "VE", "orcid": "0000-0002-8930-534X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c7185df2f7d44872960d604e9c70c551.json"}}, {"family": "Kierczak", "given": "Marcin", "initials": "M", "orcid": "0000-0003-2629-5655", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da6834c3cedf4ea1b20b659316b45eb2.json"}}, {"family": "Steiner", "given": "Cynthia C", "initials": "CC", "orcid": "0000-0002-2131-8072", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9386c16bd7e14ddca60e03e06f6808fe.json"}}, {"family": "Liu", "given": "Shanlin", "initials": "S"}, {"family": "Gilbert", "given": "M Thomas P", "initials": "MTP", "orcid": "0000-0002-5805-7195", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93cbe282154844588f63bc7cc6983b30.json"}}, {"family": "Sinding", "given": "Mikkel-Holger S", "initials": "MS", "orcid": "0000-0003-1371-219X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cebd0f43f1204602843d51ff84f94061.json"}}, {"family": "Prost", "given": "Stefan", "initials": "S", "orcid": "0000-0002-6229-3596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/290b46b14a0348c595bc2b9786f56a0b.json"}}, {"family": "Guschanski", "given": "Katerina", "initials": "K", "orcid": "0000-0002-8493-5457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e062373c6bc46b98e56215d3ec89eeb.json"}}, {"family": "Nathan", "given": "Senthilvel K S S", "initials": "SKSS"}, {"family": "Brace", "given": "Selina", "initials": "S", "orcid": "0000-0003-2126-6732", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6269e70522db48a38f585df0d10eea89.json"}}, {"family": "Chan", "given": "Yvonne L", "initials": "YL"}, {"family": "Wheat", "given": "Christopher W", "initials": "CW"}, {"family": "Skoglund", "given": "Pontus", "initials": "P"}, {"family": "Ryder", "given": "Oliver A", "initials": "OA"}, {"family": "Goossens", "given": "Benoit", "initials": "B"}, {"family": "G\u00f6therstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Dal\u00e9n", "given": "Love", "initials": "L", "orcid": "0000-0001-8270-7613", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/070030648e52418abda45f9f79688168.json"}}], "type": "historical article", "published": "2021-04-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "2393", "issn-l": "2041-1723"}, "abstract": "Small populations are often exposed to high inbreeding and mutational load that can increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is now restricted to small and isolated populations on Sumatra and Borneo, and most likely extinct on the Malay Peninsula. Here, we analyse 5 historical and 16 modern genomes from these populations to investigate the genomic consequences of the recent decline, such as increased inbreeding and mutational load. We find that the Malay Peninsula population experienced increased inbreeding shortly before extirpation, which possibly was accompanied by purging. The populations on Sumatra and Borneo instead show low inbreeding, but high mutational load. The currently small population sizes may thus in the near future lead to inbreeding depression. Moreover, we find little evidence for differences in local adaptation among populations, suggesting that future inbreeding depression could potentially be mitigated by assisted gene flow among populations.", "doi": "10.1038/s41467-021-22386-8", "pmid": "33896938", "labels": {"DDLS Fellow": "", "Tom van der Valk": ""}, "xrefs": [{"db": "pmc", "key": "PMC8071806"}, {"db": "pii", "key": "10.1038/s41467-021-22386-8"}], "notes": [], "created": "2026-09-23T07:30:00.981Z", "modified": "2026-09-23T07:30:01.277Z"}]}