{"entity": "researcher", "timestamp": "2026-08-22T10:32:28.505Z", "family": "Corr\u00eaa", "given": "Ivan R", "initials": "IR", "orcid": "0000-0002-3169-6878", "affiliations": ["New England Biolabs, Ipswich, MA, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd285ac2f2d446cf8c7ae76e9673a572.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd285ac2f2d446cf8c7ae76e9673a572"}}, "publications": [{"entity": "publication", "iuid": "81aa727bc07b4fd2a5a34d1eec0ca00f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/81aa727bc07b4fd2a5a34d1eec0ca00f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/81aa727bc07b4fd2a5a34d1eec0ca00f"}}, "title": "GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.", "authors": [{"family": "Lagou", "given": "Vasiliki", "initials": "V"}, {"family": "Jiang", "given": "Longda", "initials": "L"}, {"family": "Ulrich", "given": "Anna", "initials": "A"}, {"family": "Zudina", "given": "Liudmila", "initials": "L"}, {"family": "Gonz\u00e1lez", "given": "Karla Sofia Guti\u00e9rrez", "initials": "KSG", "orcid": "0009-0006-1948-9047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2aff1b09e0764db5b8a5951cce3d27c1.json"}}, {"family": "Balkhiyarova", "given": "Zhanna", "initials": "Z"}, {"family": "Faggian", "given": "Alessia", "initials": "A", "orcid": "0000-0002-3799-9722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a80d46f03c834ee796db8db7206095ae.json"}}, {"family": "Maina", "given": "Jared G", "initials": "JG"}, {"family": "Chen", "given": "Shiqian", "initials": "S"}, {"family": "Todorov", "given": "Petar V", "initials": "PV"}, {"family": "Sharapov", "given": "Sodbo", "initials": "S"}, {"family": "David", "given": "Alessia", "initials": "A", "orcid": "0000-0001-8687-024X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97bdb2a0efce47a08700811088fdbd0a.json"}}, {"family": "Marullo", "given": "Letizia", "initials": "L"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R", "orcid": "0000-0002-2964-6011", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c61aadd4cc6a49ddaf637030920c0a96.json"}}, {"family": "Rujan", "given": "Roxana-Maria", "initials": "RM"}, {"family": "Ahlqvist", "given": "Emma", "initials": "E", "orcid": "0000-0002-6513-2384", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f6fb443ea34629a88f3d9fc2d0c340.json"}}, {"family": "Thorleifsson", "given": "Gudmar", "initials": "G", "orcid": "0000-0003-4623-9087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3460ce8189d243829543bd5919c42588.json"}}, {"family": "Gao", "given": "\u0397e", "initials": "\u0397"}, {"family": "\u0395vangelou", "given": "\u0395vangelos", "initials": "\u0395", "orcid": "0000-0002-5488-2999", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7726e145c634702b9b55f705feaa6d4.json"}}, {"family": "Benyamin", "given": "Beben", "initials": "B"}, {"family": "Scott", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-3634-3016", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa3e293c31e04d7f9e34c1d47856e623.json"}}, {"family": "Isaacs", "given": "Aaron", "initials": "A", "orcid": "0000-0001-5037-4834", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3032ae0243754d59ae39612d49257dfd.json"}}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Willems", "given": "Sara M", "initials": "SM"}, {"family": "Johnson", "given": "Toby", "initials": "T"}, {"family": "Gieger", "given": "Christian", "initials": "C", "orcid": "0000-0001-6986-9554", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f97cdfc9ee1f4dd2a741b672b5b593d1.json"}}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Meisinger", "given": "Christa", "initials": "C"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M"}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ", "orcid": "0000-0001-8506-3585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cccd06a2fb54f769c5710c8758f2ebe.json"}}, {"family": "Goel", "given": "Anuj", "initials": "A", "orcid": "0000-0003-2307-4021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f82c700f58249b5a2f98800a4d3d247.json"}}, {"family": "Rybin", "given": "Denis", "initials": "D"}, {"family": "Albrecht", "given": "Eva", "initials": "E"}, {"family": "Jackson", "given": "Anne U", "initials": "AU", "orcid": "0000-0002-9672-2547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d63df156aa9247d3a547cdcb2c86bff5.json"}}, {"family": "Stringham", "given": "Heather M", "initials": "HM", "orcid": "0000-0002-2991-6392", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2dd6dfe13fc4068a83c42e06beaf853.json"}}, {"family": "Corr\u00eaa", "given": "Ivan R", "initials": "IR", "orcid": "0000-0002-3169-6878", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd285ac2f2d446cf8c7ae76e9673a572.json"}}, {"family": "Farber-Eger", "given": "Eric", "initials": "E", "orcid": "0000-0003-0281-3796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9781bbd9c114d2d80a8615e5fb390f3.json"}}, {"family": "Steinthorsdottir", "given": "Valgerdur", "initials": "V", "orcid": "0000-0003-1846-6274", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea512c22756d4c4c88e36f90da07afe3.json"}}, {"family": "Uitterlinden", "given": "Andr\u00e9 G", "initials": "AG", "orcid": "0000-0002-7276-3387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aee3acd4781c4c678184783464f77f1d.json"}}, {"family": "Munroe", "given": "Patricia B", "initials": "PB", "orcid": "0000-0002-4176-2947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e956b6f17a64fb4b478dbc59950a790.json"}}, {"family": "Brown", "given": "Morris J", "initials": "MJ", "orcid": "0000-0001-8409-1082", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65a9596f1f2044a2a58795b254b6aae3.json"}}, {"family": "Schmidberger", "given": "Julian", "initials": "J"}, {"family": "Holmen", "given": "Oddgeir", "initials": "O"}, {"family": "Thorand", "given": "Barbara", "initials": "B", "orcid": "0000-0002-8416-6440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1595d383d9f4ef091d369efdd59d0b7.json"}}, {"family": "Hveem", "given": "Kristian", "initials": "K"}, {"family": "Wilsgaard", "given": "Tom", "initials": "T", "orcid": "0000-0002-2709-9472", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b44e81c416ce49a9b3894bbe515ed715.json"}}, {"family": "Mohlke", "given": "Karen L", "initials": "KL", "orcid": "0000-0001-6721-153X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fac0e041c56347fe98cef9ae8f004b67.json"}}, {"family": "Wang", "given": "Zhe", "initials": "Z", "orcid": "0000-0002-8046-4969", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f925d8ce81524036b0566ce2990b55bc.json"}}, {"family": "GWA-PA Consortium", "given": "", "initials": ""}, {"family": "Shmeliov", "given": "Aleksey", "initials": "A"}, {"family": "den Hoed", "given": "Marcel", "initials": "M", "orcid": "0000-0001-8081-428X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d3e34c06cff4446ad703cde901c5033.json"}}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Kratzer", "given": "Wolfgang", "initials": "W"}, {"family": "Haenle", "given": "Mark", "initials": "M"}, {"family": "Koenig", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-2064-9603", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/69a0d603579e4202b20b7ee4f6422618.json"}}, {"family": "Boehm", "given": "Bernhard O", "initials": "BO"}, {"family": "Tan", "given": "Tricia M", "initials": "TM"}, {"family": "Tomas", "given": "Alejandra", "initials": "A"}, {"family": "Salem", "given": "Victoria", "initials": "V"}, {"family": "Barroso", "given": "In\u00eas", "initials": "I", "orcid": "0000-0001-5800-4520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72e641d8461d415e8ab6c96f902b299a.json"}}, {"family": "Tuomilehto", "given": "Jaakko", "initials": "J", "orcid": "0000-0002-3424-0745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b03750fc66434e4b92e76084e7fce15d.json"}}, {"family": "Boehnke", "given": "Michael", "initials": "M", "orcid": "0000-0002-6442-7754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e36dfed05bd94a1588f0ad628a9e39c5.json"}}, {"family": "Florez", "given": "Jose C", "initials": "JC"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Watkins", "given": "Hugh", "initials": "H"}, {"family": "Nj\u00f8lstad", "given": "Inger", "initials": "I"}, {"family": "Wichmann", "given": "H-Erich", "initials": "HE"}, {"family": "Caulfield", "given": "Mark J", "initials": "MJ", "orcid": "0000-0001-9295-3594", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b025d12d083479b8c86347e83dd05d0.json"}}, {"family": "Khaw", "given": "Kay-Tee", "initials": "KT"}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM", "orcid": "0000-0002-2374-9204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f80ecaf200f24b4092c9a6ed77dfff8d.json"}}, {"family": "Hofman", "given": "Albert", "initials": "A"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Whitfield", "given": "John B", "initials": "JB"}, {"family": "Martin", "given": "Nicholas G", "initials": "NG"}, {"family": "Montgomery", "given": "Grant", "initials": "G", "orcid": "0000-0002-4140-8139", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/803bb26becea41a298a3e9817611996e.json"}}, {"family": "Scapoli", "given": "Chiara", "initials": "C"}, {"family": "Tzoulaki", "given": "Ioanna", "initials": "I", "orcid": "0000-0002-4275-9328", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ae6de4eeff94e139ad11394689d9203.json"}}, {"family": "Elliott", "given": "Paul", "initials": "P", "orcid": "0000-0002-7511-5684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f380d322e67841e7b47ff3202991c1c4.json"}}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Stefansson", "given": "Kari", "initials": "K", "orcid": "0000-0003-1676-864X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9edf80871ac84e76a4d1316fc7079d7d.json"}}, {"family": "Brittain", "given": "Evan L", "initials": "EL", "orcid": "0000-0001-5843-3392", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d888b46105540a484aacd364ab645f9.json"}}, {"family": "McCarthy", "given": "Mark I", "initials": "MI", "orcid": "0000-0002-4393-0510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/102c7e93640c43c9bbbedd1626adfd7b.json"}}, {"family": "Froguel", "given": "Philippe", "initials": "P", "orcid": "0000-0003-2972-0784", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfa1447bfb9d4d04a5625d48f13fcd4e.json"}}, {"family": "Sexton", "given": "Patrick M", "initials": "PM"}, {"family": "Wootten", "given": "Denise", "initials": "D"}, {"family": "Groop", "given": "Leif", "initials": "L", "orcid": "0000-0002-0187-3263", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b549c1ef49648bf81c481bc88857552.json"}}, {"family": "Dupuis", "given": "Jos\u00e9e", "initials": "J", "orcid": "0000-0003-2871-3603", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdb74e8dee5d44c8ac7ee0d08de8180b.json"}}, {"family": "Meigs", "given": "James B", "initials": "JB", "orcid": "0000-0002-2439-2657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2d2678807b544abb0cc247e130614b6.json"}}, {"family": "Deganutti", "given": "Giuseppe", "initials": "G", "orcid": "0000-0001-8780-2986", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e76ac5e2d4b348269fa7bd9021d20c8d.json"}}, {"family": "Demirkan", "given": "Ayse", "initials": "A"}, {"family": "Pers", "given": "Tune H", "initials": "TH", "orcid": "0000-0003-0207-4831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5229243d3ee54140b73924a3c221ecf1.json"}}, {"family": "Reynolds", "given": "Christopher A", "initials": "CA"}, {"family": "Aulchenko", "given": "Yurii S", "initials": "YS", "orcid": "0000-0002-7899-1575", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d581818861a47f6965867c1b1138994.json"}}, {"family": "Kaakinen", "given": "Marika A", "initials": "MA"}, {"family": "Jones", "given": "Ben", "initials": "B", "orcid": "0000-0003-0461-2584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3684d9aacc2d40108962bbb7e49fd48d.json"}}, {"family": "Prokopenko", "given": "Inga", "initials": "I", "orcid": "0000-0003-1624-7457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa86d82a5dc54f53b4ff6e622b7f07fb.json"}}, {"family": "Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC)", "given": "", "initials": ""}], "type": "meta-analysis", "published": "2023-09-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "55", "issue": "9", "pages": "1448-1461", "issn-l": "1061-4036"}, "abstract": "Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations. We discovered 120 RG loci represented by 150 distinct signals, including 13 with sex-dimorphic effects, two cross-ancestry and seven rare frequency signals. Of these, 44 loci are new for glycemic traits. Regulatory, glycosylation and metagenomic annotations highlight ileum and colon tissues, indicating an underappreciated role of the gastrointestinal tract in controlling blood glucose. Functional follow-up and molecular dynamics simulations of lower frequency coding variants in glucagon-like peptide-1 receptor (GLP1R), a type 2 diabetes treatment target, reveal that optimal selection of GLP-1R agonist therapy will benefit from tailored genetic stratification. We also provide evidence from Mendelian randomization that lung function is modulated by blood glucose and that pulmonary dysfunction is a diabetes complication. Our investigation yields new insights into the biology of glucose regulation, diabetes complications and pathways for treatment stratification.", "doi": "10.1038/s41588-023-01462-3", "pmid": "37679419", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10484788"}, {"db": "pii", "key": "10.1038/s41588-023-01462-3"}], "notes": [], "created": "2026-08-21T11:51:46.118Z", "modified": "2026-08-21T11:51:47.165Z"}]}