{"entity": "researcher", "timestamp": "2026-09-25T18:00:35.514Z", "family": "N\u00e4sman", "given": "Anders", "initials": "A", "orcid": "0000-0003-4602-4297", "affiliations": ["Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden. anders.nasman@ki.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/da9e9d7a0c2241e7bf87ec4511d8e33a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/da9e9d7a0c2241e7bf87ec4511d8e33a"}}, "publications": [{"entity": "publication", "iuid": "89b4fc13d35841a4957ad573d5ff5146", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/89b4fc13d35841a4957ad573d5ff5146.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/89b4fc13d35841a4957ad573d5ff5146"}}, "title": "Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome.", "authors": [{"family": "Ramqvist", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "N\u00e4sman", "given": "Anders", "initials": "A", "orcid": "0000-0003-4602-4297", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da9e9d7a0c2241e7bf87ec4511d8e33a.json"}}, {"family": "Franz\u00e9n", "given": "Bo", "initials": "B"}, {"family": "Bersani", "given": "Cinzia", "initials": "C"}, {"family": "Alexeyenko", "given": "Andrey", "initials": "A", "orcid": "0000-0001-8812-6481", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8078f1505d9747e1ac76cf2f6d4ee606.json"}}, {"family": "Becker", "given": "Susanne", "initials": "S"}, {"family": "Haeggblom", "given": "Linnea", "initials": "L"}, {"family": "Kolev", "given": "Aeneas", "initials": "A"}, {"family": "Dalianis", "given": "Tina", "initials": "T"}, {"family": "Munck-Wikland", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2018-03-25", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "19", "issue": "4", "issn-l": null}, "abstract": "Human papillomavirus (HPV) is a major etiological factor for tonsillar and the base of tongue cancer (TSCC/BOTSCC). HPV-positive and HPV-negative TSCC/BOTSCC present major differences in mutations, mRNA expression and clinical outcome. Earlier protein studies on TSCC/BOTSCC have mainly analyzed individual proteins. Here, the aim was to compare a larger set of cancer and immune related proteins in HPV-positive and HPV-negative TSCC/BOTSCC in relation to normal tissue, presence of HPV, and clinical outcome. Fresh frozen tissue from 42 HPV-positive and 17 HPV-negative TSCC/BOTSCC, and corresponding normal samples, were analyzed for expression of 167 proteins using two Olink multiplex immunoassays. Major differences in protein expression between TSCC/BOTSCC and normal tissue were identified, especially in chemo- and cytokines. Moreover, 34 proteins, mainly immunoregulatory proteins and chemokines, were differently expressed in HPV-positive vs HPV-negative TSCC/BOTSCC. Several proteins were potentially related to clinical outcome for HPV-positive or HPV-negative tumors. For HPV-positive tumors, these were mostly related to angiogenesis and hypoxia. Correlation with clinical outcome of one of these, VEGFA, was validated by immunohistochemistry. Differences in immune related proteins between HPV-positive and HPV-negative TSCC/BOTSCC reflect the stronger activity of the immune defense in the former. Angiogenesis related proteins might serve as potential targets for therapy in HPV-positive TSCC/BOTSCC.", "doi": "10.3390/ijms19040978", "pmid": "29587383", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5979357"}, {"db": "pii", "key": "ijms19040978"}], "notes": [], "created": "2019-01-17T13:50:10.279Z", "modified": "2026-09-23T12:38:35.099Z"}]}