{"entity": "researcher", "timestamp": "2026-08-20T21:53:01.765Z", "family": "Paslawski", "given": "Wojciech", "initials": "W", "orcid": "0000-0003-2141-4547", "affiliations": ["Department of Clinical Neuroscience, Neuro Svenningsson, J5:20 Bioclinicum, Karolinska Universitetssjukhuset, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9cd03bf75b24a37884524e605253073.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9cd03bf75b24a37884524e605253073"}}, "publications": [{"entity": "publication", "iuid": "6a9ead4a969a405595755f49d3833c76", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6a9ead4a969a405595755f49d3833c76.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6a9ead4a969a405595755f49d3833c76"}}, "title": "Cerebrospinal Fluid Proteins Altered in Corticobasal Degeneration.", "authors": [{"family": "Paslawski", "given": "Wojciech", "initials": "W", "orcid": "0000-0003-2141-4547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9cd03bf75b24a37884524e605253073.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X"}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J"}, {"family": "He", "given": "Yachao", "initials": "Y"}, {"family": "Boxer", "given": "Adam", "initials": "A"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Svenningsson", "given": "Per", "initials": "P"}], "type": "letter", "published": "2021-05-00", "journal": {"title": "Mov Disord", "issn": "1531-8257", "volume": "36", "issue": "5", "pages": "1278-1280", "issn-l": null}, "abstract": null, "doi": "10.1002/mds.28543", "pmid": "33660876", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:34:26.485Z", "modified": "2026-08-20T06:34:26.573Z"}, {"entity": "publication", "iuid": "84d20166f11b44eb9a6cfe953340e83b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/84d20166f11b44eb9a6cfe953340e83b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/84d20166f11b44eb9a6cfe953340e83b"}}, "title": "\u03b1-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients.", "authors": [{"family": "Paslawski", "given": "Wojciech", "initials": "W", "orcid": "0000-0003-2141-4547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9cd03bf75b24a37884524e605253073.json"}}, {"family": "Zareba-Paslawska", "given": "Justyna", "initials": "J"}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X"}, {"family": "H\u00f6lzl", "given": "Katharina", "initials": "K"}, {"family": "Wadensten", "given": "Henrik", "initials": "H"}, {"family": "Shariatgorji", "given": "Mohammadreza", "initials": "M"}, {"family": "Janelidze", "given": "Shorena", "initials": "S"}, {"family": "Hansson", "given": "Oskar", "initials": "O"}, {"family": "Forsgren", "given": "Lars", "initials": "L"}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2019-07-23", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "116", "issue": "30", "pages": "15226-15235", "issn-l": "0027-8424"}, "abstract": "The progressive accumulation, aggregation, and spread of \u03b1-synuclein (\u03b1SN) are common hallmarks of Parkinson's disease (PD) pathology. Moreover, numerous proteins interact with \u03b1SN species, influencing its toxicity in the brain. In the present study, we extended analyses of \u03b1SN-interacting proteins to cerebrospinal fluid (CSF). Using coimmunoprecipitation, followed by mass spectrometry, we found that \u03b1SN colocalize with apolipoproteins on lipoprotein vesicles. We confirmed these interactions using several methods, including the enrichment of lipoproteins with a recombinant \u03b1SN, and the subsequent uptake of prepared vesicles by human dopaminergic neuronal-like cells. Further, we report an increased level of ApoE in CSF from early PD patients compared with matched controls in 3 independent cohorts. Moreover, in contrast to controls, we observed the presence of ApoE-positive neuromelanin-containing dopaminergic neurons in substantia nigra of PD patients. In conclusion, the cooccurrence of \u03b1SN on lipoprotein vesicles, and their uptake by dopaminergic neurons along with an increase of ApoE in early PD, proposes a mechanism(s) for \u03b1SN spreading in the extracellular milieu of PD.", "doi": "10.1073/pnas.1821409116", "pmid": "31270237", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6660770"}, {"db": "pii", "key": "1821409116"}], "notes": [], "created": "2026-08-20T09:30:15.336Z", "modified": "2026-08-20T09:30:15.379Z"}]}