{"entity": "researcher", "timestamp": "2026-08-20T20:37:33.877Z", "family": "Carannante", "given": "Ilaria", "initials": "I", "orcid": "0000-0001-8210-8709", "affiliations": ["Department of Computational Science and Technology, Science for Life Laboratory, The Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d94ae668884641ec9ba2713e0db64d61.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d94ae668884641ec9ba2713e0db64d61"}}, "publications": [{"entity": "publication", "iuid": "e799bf76a2334aad9c686bb13e7bc707", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e799bf76a2334aad9c686bb13e7bc707.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e799bf76a2334aad9c686bb13e7bc707"}}, "title": "The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.", "authors": [{"family": "Carannante", "given": "Ilaria", "initials": "I", "orcid": "0000-0001-8210-8709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d94ae668884641ec9ba2713e0db64d61.json"}}, {"family": "Scolamiero", "given": "Martina", "initials": "M"}, {"family": "Hjorth", "given": "J J Johannes", "initials": "JJJ", "orcid": "0000-0002-9302-0750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec9300bb976d4038a766d908fcd0ce86.json"}}, {"family": "Kozlov", "given": "Alexander", "initials": "A"}, {"family": "Bekkouche", "given": "Bo", "initials": "B"}, {"family": "Guo", "given": "Lihao", "initials": "L", "orcid": "0000-0002-9982-6229", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3adb76adf48468092952ae4809796d2.json"}}, {"family": "Kumar", "given": "Arvind", "initials": "A", "orcid": "0000-0002-8044-9195", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2fe30252074acb8d09f88f6c9b55f3.json"}}, {"family": "Chach\u00f3lski", "given": "Wojciech", "initials": "W", "orcid": "0000-0002-2665-9001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59be49fa28984d38ac328e451be56820.json"}}, {"family": "Kotaleski", "given": "Jeanette Hellgren", "initials": "JH", "orcid": "0000-0002-0550-0739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a920517bd1c142878f03bee05e843b62.json"}}], "type": "journal article", "published": "2024-12-10", "journal": {"title": "Netw Neurosci", "issn": "2472-1751", "volume": "8", "issue": "4", "pages": "1149-1172", "issn-l": null}, "abstract": "Striatum, the input stage of the basal ganglia, is important for sensory-motor integration, initiation and selection of behavior, as well as reward learning. Striatum receives glutamatergic inputs from mainly cortex and thalamus. In rodents, the striatal projection neurons (SPNs), giving rise to the direct and the indirect pathway (dSPNs and iSPNs, respectively), account for 95% of the neurons, and the remaining 5% are GABAergic and cholinergic interneurons. Interneuron axon terminals as well as local dSPN and iSPN axon collaterals form an intricate striatal network. Following chronic dopamine depletion as in Parkinson's disease (PD), both morphological and electrophysiological striatal neuronal features have been shown to be altered in rodent models. Our goal with this in silico study is twofold: (a) to predict and quantify how the intrastriatal network connectivity structure becomes altered as a consequence of the morphological changes reported at the single-neuron level and (b) to investigate how the effective glutamatergic drive to the SPNs would need to be altered to account for the activity level seen in SPNs during PD. In summary, we predict that the richness of the connectivity motifs in the striatal network is significantly decreased during PD while, at the same time, a substantial enhancement of the effective glutamatergic drive to striatum is present.", "doi": "10.1162/netn_a_00394", "pmid": "39735495", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11674317"}, {"db": "pii", "key": "netn_a_00394"}], "notes": [], "created": "2026-08-20T12:16:23.614Z", "modified": "2026-08-20T12:16:23.766Z"}, {"entity": "publication", "iuid": "45cb181d297749bba1ef1d84aa001856", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/45cb181d297749bba1ef1d84aa001856.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/45cb181d297749bba1ef1d84aa001856"}}, "title": "Reciprocal interaction between striatal cholinergic and low-threshold spiking interneurons - A computational study.", "authors": [{"family": "Frost Nyl\u00e9n", "given": "Johanna", "initials": "J", "orcid": "0000-0001-6863-8893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b679645c02544e9947f45d55cfeb813.json"}}, {"family": "Carannante", "given": "Ilaria", "initials": "I", "orcid": "0000-0001-8210-8709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d94ae668884641ec9ba2713e0db64d61.json"}}, {"family": "Grillner", "given": "Sten", "initials": "S", "orcid": "0000-0002-8951-3691", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18eacd075f8e45c888e6ed7233928b35.json"}}, {"family": "Hellgren Kotaleski", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-0550-0739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a920517bd1c142878f03bee05e843b62.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Eur. J. Neurosci.", "issn": "1460-9568", "volume": "53", "issue": "7", "pages": "2135-2148", "issn-l": "0953-816X"}, "abstract": "The striatum is the main input stage of the basal ganglia receiving extrinsic input from cortex and thalamus. The striatal projection neurons (SPN) constitute 95% of the neurons in the striatum in mice while the remaining 5% are cholinergic and GABAergic interneurons. The cholinergic (ChIN) and low-threshold spiking interneurons (LTS) are spontaneously active and form a striatal subnetwork involved in salience detection and goal-directed learning. Activation of ChINs has been shown to inhibit LTS via muscarinic receptor type 4 (M4R) and LTS in turn can modulate ChINs via nitric oxide (NO) causing a prolonged depolarization. Thalamic input prefentially excites ChINs, whereas input from motor cortex favours LTS, but can also excite ChINs. This varying extrinsic input with intrinsic reciprocal, yet opposing, effects raises the possibility of a slow input-dependent modulatory subnetwork. Here, we simulate this subnetwork using multicompartmental neuron models that incorporate data regarding known ion channels and detailed morphological reconstructions. The modelled connections replicate the experimental data on muscarinic (M4R) and nitric oxide modulation onto LTS and ChIN, respectively, and capture their physiological interaction. Finally, we show that the cortical and thalamic inputs triggering the opposing modulation within the network induce periods of increased and decreased spiking activity in ChINs and LTS. This could provide different temporal windows for selective modulation by acetylcholine and nitric oxide, and the possibility of interaction with the wider striatal microcircuit.", "doi": "10.1111/ejn.14854", "pmid": "32511809", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:17:42.703Z", "modified": "2026-08-20T11:17:42.814Z"}]}