{"entity": "researcher", "timestamp": "2026-09-23T14:54:45.550Z", "family": "Camacho", "given": "Juan Pedro M", "initials": "JPM", "orcid": "0000-0002-2507-9814", "affiliations": ["Department of Genetics, University of Granada, E-18071, Granada, Spain."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9378abc13c348f18fb6de3fea221311.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9378abc13c348f18fb6de3fea221311"}}, "publications": [{"entity": "publication", "iuid": "63cb0e71bf294245bcc215e11a74d20f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/63cb0e71bf294245bcc215e11a74d20f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/63cb0e71bf294245bcc215e11a74d20f"}}, "title": "Occasional paternal inheritance of the germline-restricted chromosome in songbirds.", "authors": [{"family": "Pei", "given": "Yifan", "initials": "Y", "orcid": "0000-0002-2411-4454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f89c9be70df04b05bbe8bc30945c854f.json"}}, {"family": "Forstmeier", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-5984-8925", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecb710f7c6a34435b03de70f2bddfc38.json"}}, {"family": "Ruiz-Ruano", "given": "Francisco J", "initials": "FJ", "orcid": "0000-0002-5391-301X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6c9c69ad6644f77bfe61a99ec3e8fd0.json"}}, {"family": "Mueller", "given": "Jakob C", "initials": "JC", "orcid": "0000-0001-6676-7595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7871afc2a329427a8d06c00aea9acfce.json"}}, {"family": "Cabrero", "given": "Josefa", "initials": "J", "orcid": "0000-0002-5848-6985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b755ff0ab3384aaba07c20ce6ae7a738.json"}}, {"family": "Camacho", "given": "Juan Pedro M", "initials": "JPM", "orcid": "0000-0002-2507-9814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9378abc13c348f18fb6de3fea221311.json"}}, {"family": "Alch\u00e9", "given": "Juan D", "initials": "JD", "orcid": "0000-0002-7547-6025", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b8e770bab6a45cba594944cff22323b.json"}}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Hoeppner", "given": "Marc", "initials": "M"}, {"family": "B\u00f6rno", "given": "Stefan", "initials": "S", "orcid": "0000-0002-7990-9625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4cdfd7df1cf408f83b686b5ceccac8b.json"}}, {"family": "Gessara", "given": "Ivana", "initials": "I", "orcid": "0000-0001-9834-9013", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21ae972b90d34562bb5b151f42f8fadf.json"}}, {"family": "Hertel", "given": "Moritz", "initials": "M"}, {"family": "Teltscher", "given": "Kim", "initials": "K", "orcid": "0000-0003-3997-7399", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/14c47e12533c40b1b93ce6e59e6ba1b5.json"}}, {"family": "Knief", "given": "Ulrich", "initials": "U", "orcid": "0000-0001-6959-3033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41faddaa4cc1445e854ba4a62298507d.json"}}, {"family": "Suh", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8979-9992", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1790a31477c4376957d8c328299db1c.json"}}, {"family": "Kempenaers", "given": "Bart", "initials": "B", "orcid": "0000-0002-7505-5458", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6771e71dc2114c6a98eeae371c75fe59.json"}}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "119", "issue": "4", "issn-l": "0027-8424"}, "abstract": "Songbirds have one special accessory chromosome, the so-called germline-restricted chromosome (GRC), which is only present in germline cells and absent from all somatic tissues. Earlier work on the zebra finch (Taeniopygia guttata castanotis) showed that the GRC is inherited only through the female line-like the mitochondria-and is eliminated from the sperm during spermatogenesis. Here, we show that the GRC has the potential to be paternally inherited. Confocal microscopy using GRC-specific fluorescent in situ hybridization probes indicated that a considerable fraction of sperm heads (1 to 19%) in zebra finch ejaculates still contained the GRC. In line with these cytogenetic data, sequencing of ejaculates revealed that individual males from two families differed strongly and consistently in the number of GRCs in their ejaculates. Examining a captive-bred male hybrid of the two zebra finch subspecies (T. g. guttata and T. g. castanotis) revealed that the mitochondria originated from a castanotis mother, whereas the GRC came from a guttata father. Moreover, analyzing GRC haplotypes across nine castanotis matrilines, estimated to have diverged for up to 250,000 y, showed surprisingly little variability among GRCs. This suggests that a single GRC haplotype has spread relatively recently across all examined matrilines. A few diagnostic GRC mutations that arose since this inferred spreading suggest that the GRC has continued to jump across matriline boundaries. Our findings raise the possibility that certain GRC haplotypes could selfishly spread through the population via occasional paternal transmission, thereby outcompeting other GRC haplotypes that were limited to strict maternal inheritance, even if this was partly detrimental to organismal fitness.", "doi": "10.1073/pnas.2103960119", "pmid": "35058355", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8794876"}, {"db": "pii", "key": "2103960119"}], "notes": [], "created": "2026-09-23T10:06:20.517Z", "modified": "2026-09-23T10:06:20.913Z"}, {"entity": "publication", "iuid": "92a5b042f3fd48ceafa5ba21568aa533", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/92a5b042f3fd48ceafa5ba21568aa533.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/92a5b042f3fd48ceafa5ba21568aa533"}}, "title": "Occasional paternal inheritance of the germline-restricted chromosome in songbirds", "authors": [{"family": "Pei", "given": "Yifan", "initials": "Y", "orcid": "0000-0002-2411-4454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f89c9be70df04b05bbe8bc30945c854f.json"}}, {"family": "Forstmeier", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-5984-8925", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecb710f7c6a34435b03de70f2bddfc38.json"}}, {"family": "Ruiz-Ruano", "given": "Francisco J", "initials": "FJ", "orcid": "0000-0002-5391-301X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6c9c69ad6644f77bfe61a99ec3e8fd0.json"}}, {"family": "Mueller", "given": "Jakob C", "initials": "JC", "orcid": "0000-0001-6676-7595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7871afc2a329427a8d06c00aea9acfce.json"}}, {"family": "Cabrero", "given": "Josefa", "initials": "J", "orcid": "0000-0002-5848-6985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b755ff0ab3384aaba07c20ce6ae7a738.json"}}, {"family": "Camacho", "given": "Juan Pedro M", "initials": "JPM", "orcid": "0000-0002-2507-9814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9378abc13c348f18fb6de3fea221311.json"}}, {"family": "Alch\u00e9", "given": "Juan D", "initials": "JD", "orcid": "0000-0002-7547-6025", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b8e770bab6a45cba594944cff22323b.json"}}, {"family": "Franke", "given": "Andre", "initials": "A"}, {"family": "Hoeppner", "given": "Marc", "initials": "M"}, {"family": "B\u00f6rno", "given": "Stefan", "initials": "S"}, {"family": "Gessara", "given": "Ivana", "initials": "I", "orcid": "0000-0001-9834-9013", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21ae972b90d34562bb5b151f42f8fadf.json"}}, {"family": "Hertel", "given": "Moritz", "initials": "M"}, {"family": "Teltscher", "given": "Kim", "initials": "K"}, {"family": "Knief", "given": "Ulrich", "initials": "U", "orcid": "0000-0001-6959-3033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41faddaa4cc1445e854ba4a62298507d.json"}}, {"family": "Suh", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8979-9992", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1790a31477c4376957d8c328299db1c.json"}}, {"family": "Kempenaers", "given": "Bart", "initials": "B", "orcid": "0000-0002-7505-5458", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6771e71dc2114c6a98eeae371c75fe59.json"}}], "type": "posted-content", "published": "2021-01-28", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.01.28.428604", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T14:10:31.520Z", "modified": "2026-09-23T14:10:31.848Z"}, {"entity": "publication", "iuid": "e9ddc0659139439aa65154124851ac91", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e9ddc0659139439aa65154124851ac91.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e9ddc0659139439aa65154124851ac91"}}, "title": "Programmed DNA elimination of germline development genes in songbirds.", "authors": [{"family": "Kinsella", "given": "Cormac M", "initials": "CM", "orcid": "0000-0001-9865-4608", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/772bfbaa9ca14161980526ba81082d3c.json"}}, {"family": "Ruiz-Ruano", "given": "Francisco J", "initials": "FJ", "orcid": "0000-0002-5391-301X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6c9c69ad6644f77bfe61a99ec3e8fd0.json"}}, {"family": "Dion-C\u00f4t\u00e9", "given": "Anne-Marie", "initials": "AM"}, {"family": "Charles", "given": "Alexander J", "initials": "AJ", "orcid": "0000-0003-3965-1559", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/650705b3b1a84f0097e86bdf8ed99424.json"}}, {"family": "Gossmann", "given": "Toni I", "initials": "TI", "orcid": "0000-0001-6609-4116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c82f56870502467bb10905b5612c8ff0.json"}}, {"family": "Cabrero", "given": "Josefa", "initials": "J"}, {"family": "Kappei", "given": "Dennis", "initials": "D", "orcid": "0000-0002-3582-2253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/90d7165fe1b14c619304863a6ce22a29.json"}}, {"family": "Hemmings", "given": "Nicola", "initials": "N"}, {"family": "Simons", "given": "Mirre J P", "initials": "MJP"}, {"family": "Camacho", "given": "Juan Pedro M", "initials": "JPM", "orcid": "0000-0002-2507-9814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9378abc13c348f18fb6de3fea221311.json"}}, {"family": "Forstmeier", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-5984-8925", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecb710f7c6a34435b03de70f2bddfc38.json"}}, {"family": "Suh", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8979-9992", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1790a31477c4376957d8c328299db1c.json"}}], "type": "journal article", "published": "2019-11-29", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "10", "issue": "1", "pages": "5468", "issn-l": "2041-1723"}, "abstract": "In some eukaryotes, germline and somatic genomes differ dramatically in their composition. Here we characterise a major germline-soma dissimilarity caused by a germline-restricted chromosome (GRC) in songbirds. We show that the zebra finch GRC contains >115 genes paralogous to single-copy genes on 18 autosomes and the Z chromosome, and is enriched in genes involved in female gonad development. Many genes are likely functional, evidenced by expression in testes and ovaries at the RNA and protein level. Using comparative genomics, we show that genes have been added to the GRC over millions of years of evolution, with embryonic development genes bicc1 and trim71 dating to the ancestor of songbirds and dozens of other genes added very recently. The somatic elimination of this evolutionarily dynamic chromosome in songbirds implies a unique mechanism to minimise genetic conflict between germline and soma, relevant to antagonistic pleiotropy, an evolutionary process underlying ageing and sexual traits.", "doi": "10.1038/s41467-019-13427-4", "pmid": "31784533", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6884545"}, {"db": "pii", "key": "10.1038/s41467-019-13427-4"}], "notes": [], "created": "2026-09-23T07:41:30.563Z", "modified": "2026-09-23T07:41:30.874Z"}]}