{"entity": "researcher", "timestamp": "2026-08-15T12:38:18.525Z", "family": "Harro", "given": "Jaanus", "initials": "J", "orcid": "0000-0002-4484-2096", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7c56c0dc7e44192baf30ecbcfa31330.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7c56c0dc7e44192baf30ecbcfa31330"}}, "publications": [{"entity": "publication", "iuid": "b0109b53d3f6472682e71fe7246641ea", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b0109b53d3f6472682e71fe7246641ea.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b0109b53d3f6472682e71fe7246641ea"}}, "title": "Association between Transcription Factor AP-2B genotype, obesity, insulin resistance and dietary intake in a longitudinal birth cohort study.", "authors": [{"family": "Joost", "given": "Urmeli", "initials": "U"}, {"family": "Villa", "given": "Inga", "initials": "I"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Oreland", "given": "Lars", "initials": "L"}, {"family": "Veidebaum", "given": "Toomas", "initials": "T"}, {"family": "Harro", "given": "Jaanus", "initials": "J", "orcid": "0000-0002-4484-2096", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7c56c0dc7e44192baf30ecbcfa31330.json"}}], "type": "journal article", "published": "2019-10-00", "journal": {"title": "Int J Obes (Lond)", "issn": "1476-5497", "issn-l": "0307-0565", "volume": "43", "issue": "10", "pages": "2095-2106"}, "abstract": "The development of obesity has a large genetic component, and the gene encoding the transcription factor 2 beta (TFAP2B) has been identified as one of the responsible factors. We investigated the effect of TFAP2B intron 2 variable number tandem repeat (VNTR) genotype on obesity, insulin resistance and dietary intake from 15 to 33 years of age.\n\nThe sample included both birth cohorts (originally n = 1176) of the longitudinal Estonian Children Personality Behaviour and Health Study. The association between TFAP2B genotype, and anthropometric measurements, glucose metabolism and dietary intake at ages 15, 18 and 25 years was assessed using the linear mixed-effects regression models. Differences in anthropometric measurements, biochemical measures, blood pressure and dietary intake between TFAP2B genotypes at different age, including data of the older cohort at age 33, were assessed by one-way ANOVA.\n\nMale homozygotes for the TFAP2B 5-repeat allele had significantly higher body weight, body mass index, sum of 5 skinfolds, proportion of body fat, waist circumference, hip circumference, waist-to-hip ratio, waist-to-height ratio, fasting insulin and HOMA index. In female subjects, homozygotes for the TFAP2B 5-repeat allele had significantly larger increase in the rate of change per year in body weight, body mass index and hip circumference between years 15 and 25. By age 33, the findings were similar. A decrease in daily energy intake from adolescence to young adulthood was observed. In males, heterozygotes had significantly smaller decrease in the rate of change per year in daily energy intake.\n\nThe association of TFAP2B with the development of obesity and insulin resistance is present throughout adolescence to young adulthood in males. In females the effect of TFAP2B on obesity appears later, in young adulthood. The TFAP2B effect is rather related to differences in metabolism than energy intake.", "doi": "10.1038/s41366-019-0396-y", "pmid": "31209268", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1038/s41366-019-0396-y"}], "notes": [], "created": "2020-09-28T11:49:43.996Z", "modified": "2024-10-24T08:55:35.643Z"}, {"entity": "publication", "iuid": "ba043fdd068549f3bfd4e065baefeb9a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ba043fdd068549f3bfd4e065baefeb9a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ba043fdd068549f3bfd4e065baefeb9a"}}, "title": "Personality and the serotonin transporter gene: Associations in a longitudinal population-based study.", "authors": [{"family": "Harro", "given": "Jaanus", "initials": "J", "orcid": "0000-0002-4484-2096", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7c56c0dc7e44192baf30ecbcfa31330.json"}}, {"family": "Meren\u00e4kk", "given": "Liis", "initials": "L"}, {"family": "Nordquist", "given": "Niklas", "initials": "N"}, {"family": "Konstabel", "given": "Kenn", "initials": "K"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Oreland", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2009-04-00", "journal": {"title": "Biol Psychol", "issn": "1873-6246", "volume": "81", "issue": "1", "pages": "9-13", "issn-l": "0301-0511"}, "abstract": "Associations between the promoter polymorphism of the serotonin transporter gene (5-HTTLPR) and anxiety-related personality traits in healthy adult subjects have been inconsistent. We assessed personality in participants of the Estonian Children Personality Behaviour and Health Study, using parental reports and self-reports. In the younger cohort, according to parental assessments at ages 9 and 15, children homozygous for the S allele had significantly higher scores of Neuroticism and lower scores of Openness, Agreeableness and Conscientiousness. Parental assessment of the older cohort at ages 15 and 18 did not yield any genotype effect on personality; however, interaction of cohort and genotype was not significant. According to self-reports, SS homozygotes had higher Neuroticism at age 15 but not at age 18. Thus, homozygocity for the S allele of the 5-HTTLPR is related to anxiety-related personality traits in general population, but this is easier to detect before adolescence.", "doi": "10.1016/j.biopsycho.2009.01.001", "pmid": "19437595", "labels": {"SciLifeLab Fellow": null, "Erika Comasco": null}, "xrefs": [{"db": "pii", "key": "S0301-0511(09)00002-7"}], "notes": [], "created": "2025-09-10T18:13:51.587Z", "modified": "2025-10-23T08:53:20.720Z"}]}