{"entity": "researcher", "timestamp": "2026-09-26T00:45:29.293Z", "family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "affiliations": ["Department of Medical Biochemistry and Biophysics, SciLifeLab and Karolinska Institute, Solna, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a"}}, "publications": [{"entity": "publication", "iuid": "f5aa84a9852742eeb7c097da2a0a9e4f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f5aa84a9852742eeb7c097da2a0a9e4f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f5aa84a9852742eeb7c097da2a0a9e4f"}}, "title": "An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer.", "authors": [{"family": "S\u00f6derqvist", "given": "Sara", "initials": "S"}, {"family": "Viljamaa", "given": "Annika", "initials": "A", "orcid": "0009-0002-8511-8181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad54bd86380f48b99fc405a6466f5e5e.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N"}, {"family": "Keller", "given": "Anna-Lena", "initials": "AL"}, {"family": "Ruksha", "given": "Kseniya", "initials": "K"}, {"family": "Strell", "given": "Carina", "initials": "C", "orcid": "0000-0002-3783-7256", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f288539ea7eb406480c84ec1a5605a91.json"}}, {"family": "Hekmati", "given": "Neda", "initials": "N"}, {"family": "Niculae", "given": "Alexandra", "initials": "A"}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Salm\u00e9n", "given": "Caroline", "initials": "C"}, {"family": "Costa", "given": "T\u00e2nia D F", "initials": "TDF", "orcid": "0000-0002-6296-5225", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93606f4fc34a4e088f63303d4bb9b7dc.json"}}, {"family": "Zhao", "given": "Miao", "initials": "M", "orcid": "0000-0002-4895-1177", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75b5d6dc5cde46b8aca859fb961bf1de.json"}}, {"family": "Str\u00f6mblad", "given": "Staffan", "initials": "S", "orcid": "0000-0002-1236-6339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eaaec7c2564a4cb5827a794027518796.json"}}, {"family": "Zacharouli", "given": "Argyro", "initials": "A"}, {"family": "Ghorbani", "given": "Poya", "initials": "P"}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Milanova", "given": "Stefina", "initials": "S"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Fern\u00e1ndez Moro", "given": "Carlos", "initials": "C", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "journal article", "published": "2025-09-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8307", "issn-l": "2041-1723"}, "abstract": "Pancreatic cancer is an aggressive disease with a dense fibrotic stroma and is often accompanied by chronic inflammation. Peritumoral inflammation is typically viewed as a reaction to nearby tumor growth. Here, we report that the inflamed pancreatic lobules are frequently invaded by tumor cells, forming a distinct, non-fibrotic tumor niche. Using a semi-supervised machine learning approach for annotations of clinical samples and multiplex protein profiling, we show that tumor cells at the invasion front are closely associated with acinar cells undergoing damage-induced changes, and with activated fibroblasts expressing markers of injury. The invaded lobules are linked to classical tumor phenotypes, in contrast to fibrotic areas where tumor cells display a more basal profile, highlighting microenvironment-dependent tumor subtype differences. In female mice, lobular invasion similarly aligns with the classical tumor phenotype. Together, our data reveal that pancreatic tumors colonize injured lobules, creating a unique niche that shapes tumor characteristics and contributes to disease biology.", "doi": "10.1038/s41467-025-63864-7", "pmid": "41006303", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12475445"}, {"db": "pii", "key": "10.1038/s41467-025-63864-7"}], "notes": [], "created": "2026-09-23T11:34:17.684Z", "modified": "2026-09-23T11:34:17.901Z"}, {"entity": "publication", "iuid": "91f9678080f2426a8d65f88d7779e811", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/91f9678080f2426a8d65f88d7779e811.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/91f9678080f2426a8d65f88d7779e811"}}, "title": "Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity.", "authors": [{"family": "Fan", "given": "Chuannan", "initials": "C", "orcid": "0000-0001-8754-4913", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3883a7dff51e4a8e9cb677ccd8c4857e.json"}}, {"family": "Wang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-5196-4972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6df148a1ae5249e79d51bf00aa9e0dc0.json"}}, {"family": "Krijger", "given": "Peter H L", "initials": "PHL", "orcid": "0000-0003-1702-348X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ff516ab32ea4d4b9f5a772ca5a34313.json"}}, {"family": "Cats", "given": "Davy", "initials": "D", "orcid": "0000-0001-9684-220X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24e0936de4a94d2897a553394a72b46c.json"}}, {"family": "Selle", "given": "Miriam", "initials": "M"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Dhanjal", "given": "Soniya", "initials": "S"}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Mei", "given": "Hailiang", "initials": "H"}, {"family": "de Laat", "given": "Wouter", "initials": "W", "orcid": "0000-0002-5603-0095", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e6fadae5d7d4169bdf8742e9eb18270.json"}}, {"family": "Ten Dijke", "given": "Peter", "initials": "P", "orcid": "0000-0002-7234-342X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2193ff2b5f924395ac6d4a9ddd53f20e.json"}}], "type": "journal article", "published": "2025-03-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "2890", "issn-l": "2041-1723"}, "abstract": "Enhancer RNAs (eRNAs) are a pivotal class of enhancer-derived non-coding RNAs that drive gene expression. Here we identify the SNAI1 enhancer RNA (SNAI1e; SCREEM2) as a key activator of SNAI1 expression and a potent enforcer of transforming growth factor-\u03b2 (TGF-\u03b2)/SMAD signaling in cancer cells. SNAI1e depletion impairs TGF-\u03b2-induced epithelial-mesenchymal transition (EMT), migration, in vivo extravasation, stemness, and chemotherapy resistance in breast cancer cells. SNAI1e functions as an eRNA to cis-regulate SNAI1 enhancer activity by binding to and strengthening the enrichment of the transcriptional co-activator bromodomain containing protein 4 (BRD4) at the local enhancer. SNAI1e selectively promotes the expression of SNAI1, which encodes the EMT transcription factor SNAI1. Furthermore, we reveal that SNAI1 interacts with and anchors the inhibitory SMAD7 in the nucleus, and thereby prevents TGF-\u03b2 type I receptor (T\u03b2RI) polyubiquitination and proteasomal degradation. Our findings establish SNAI1e as a critical driver of SNAI1 expression and TGF-\u03b2-induced cell plasticity.", "doi": "10.1038/s41467-025-58032-w", "pmid": "40133308", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11937597"}, {"db": "pii", "key": "10.1038/s41467-025-58032-w"}], "notes": [], "created": "2026-09-23T11:30:25.667Z", "modified": "2026-09-23T11:30:25.939Z"}, {"entity": "publication", "iuid": "d26a4278f9b14c14ba5410b71cfecc50", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d26a4278f9b14c14ba5410b71cfecc50.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d26a4278f9b14c14ba5410b71cfecc50"}}, "title": "A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype", "authors": [{"family": "S\u00f6derqvist", "given": "Sara", "initials": "S", "orcid": "0009-0003-2133-6400", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00a39720179d4e38aa6e224299d4117c.json"}}, {"family": "Viljamaa", "given": "Annika", "initials": "A", "orcid": "0009-0002-8511-8181", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad54bd86380f48b99fc405a6466f5e5e.json"}}, {"family": "Geyer", "given": "Natalie", "initials": "N", "orcid": "0000-0003-1026-968X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c229df5d458445d995fadff597d6a0d4.json"}}, {"family": "Strell", "given": "Carina", "initials": "C", "orcid": "0000-0002-3783-7256", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f288539ea7eb406480c84ec1a5605a91.json"}}, {"family": "Hekmati", "given": "Neda", "initials": "N", "orcid": "0009-0009-4814-869X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1627d2402a114b7ea2aed6cb0774e930.json"}}, {"family": "Engstrand", "given": "Jennie", "initials": "J", "orcid": "0000-0003-1123-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/972ae8ebf2634566bed8ebca7caa68ec.json"}}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Salm\u00e9n", "given": "Caroline", "initials": "C"}, {"family": "Heuchel", "given": "Rainer L", "initials": "RL", "orcid": "0000-0002-2782-585X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b61dc159c5764feba88e3fa2a35d1ad7.json"}}, {"family": "Zacharouli", "given": "Argyro", "initials": "A"}, {"family": "Ghorbani", "given": "Poya", "initials": "P", "orcid": "0000-0003-2102-7168", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37d164f0a26d4bf4aa8ad1aa4505f92e.json"}}, {"family": "Harrizi", "given": "Sara", "initials": "S"}, {"family": "Hamidi", "given": "Yousra", "initials": "Y"}, {"family": "Khorosjutina", "given": "Olga", "initials": "O", "orcid": "0009-0001-0786-0260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d758b02263464940ab8c7922b68b580a.json"}}, {"family": "Milanova", "given": "Stefina", "initials": "S", "orcid": "0000-0001-9865-857X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/653b408e1e894d3a9bd22564ac3ec1dd.json"}}, {"family": "Schmierer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-9082-7022", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95decb70bc9d4dc2820259b5971e342f.json"}}, {"family": "Boz\u00f3ky", "given": "B\u00e9la", "initials": "B"}, {"family": "Moro", "given": "Carlos Fern\u00e1ndez", "initials": "CF", "orcid": "0000-0001-6863-5959", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b9e861a77874d87a34a4894bd38daf5.json"}}, {"family": "Gerling", "given": "Marco", "initials": "M", "orcid": "0000-0002-1810-0662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73d0af14271b446b8ce3779d6beea16c.json"}}], "type": "posted-content", "published": "2024-03-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.03.14.584614", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T15:33:01.279Z", "modified": "2026-09-23T15:33:01.532Z"}]}