{"entity": "researcher", "timestamp": "2026-08-20T21:04:37.252Z", "family": "Sourjik", "given": "Victor", "initials": "V", "orcid": "0000-0003-1053-9192", "affiliations": ["Max Planck Institute for Terrestrial Microbiology, and Center for Synthetic Microbiology (SYNMIKRO), Marburg, Germany."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6aef6aa6af54827905ff16a446d27d0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6aef6aa6af54827905ff16a446d27d0"}}, "publications": [{"entity": "publication", "iuid": "0a8add1340db46c8acdea6e91aa01ab1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0a8add1340db46c8acdea6e91aa01ab1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0a8add1340db46c8acdea6e91aa01ab1"}}, "title": "D-amino acids signal a stress-dependent run-away response in Vibrio cholerae.", "authors": [{"family": "Irazoki", "given": "Oihane", "initials": "O", "orcid": "0000-0002-8896-7480", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/92d1aa46064a4ca1824bc91ffd7141c9.json"}}, {"family": "Ter Beek", "given": "Josy", "initials": "J", "orcid": "0000-0003-4165-9277", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b3d76493e80b4b57a951a0f94e6123ca.json"}}, {"family": "Alvarez", "given": "Laura", "initials": "L", "orcid": "0000-0003-2429-7542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/329d8b1460fe44789dbef53ea0493294.json"}}, {"family": "Mateus", "given": "Andr\u00e9", "initials": "A", "orcid": "0000-0001-6870-0677", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebf0d242aa894a66b60828456bbc22aa.json"}}, {"family": "Colin", "given": "Remy", "initials": "R", "orcid": "0000-0001-9051-8003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48fcedae27254c06880cc48ad7276d9f.json"}}, {"family": "Typas", "given": "Athanasios", "initials": "A", "orcid": "0000-0002-0797-9018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d38ea7a531ad47cfa26df998f0e54dbe.json"}}, {"family": "Savitski", "given": "Mikhail M", "initials": "MM", "orcid": "0000-0003-2011-9247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/374222bd4bce42f282690629b9679628.json"}}, {"family": "Sourjik", "given": "Victor", "initials": "V", "orcid": "0000-0003-1053-9192", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6aef6aa6af54827905ff16a446d27d0.json"}}, {"family": "Berntsson", "given": "Ronnie P-A", "initials": "RP", "orcid": "0000-0001-6848-322X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb9399248b784100a8020261949fb910.json"}}, {"family": "Cava", "given": "Felipe", "initials": "F", "orcid": "0000-0001-5995-718X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbcff12a06814d54afea533e125a1213.json"}}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "Nat. Microbiol", "issn": "2058-5276", "volume": "8", "issue": "8", "pages": "1549-1560", "issn-l": "2058-5276"}, "abstract": "To explore favourable niches while avoiding threats, many bacteria use a chemotaxis navigation system. Despite decades of studies on chemotaxis, most signals and sensory proteins are still unknown. Many bacterial species release D-amino acids to the environment; however, their function remains largely unrecognized. Here we reveal that D-arginine and D-lysine are chemotactic repellent signals for the cholera pathogen Vibrio cholerae. These D-amino acids are sensed by a single chemoreceptor MCPDRK co-transcribed with the racemase enzyme that synthesizes them under the control of the stress-response sigma factor RpoS. Structural characterization of this chemoreceptor bound to either D-arginine or D-lysine allowed us to pinpoint the residues defining its specificity. Interestingly, the specificity for these D-amino acids appears to be restricted to those MCPDRK orthologues transcriptionally linked to the racemase. Our results suggest that D-amino acids can shape the biodiversity and structure of complex microbial communities under adverse conditions.", "doi": "10.1038/s41564-023-01419-6", "pmid": "37365341", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10390336"}, {"db": "pii", "key": "10.1038/s41564-023-01419-6"}], "notes": [], "created": "2026-08-20T08:55:21.117Z", "modified": "2026-08-20T08:55:21.397Z"}]}