{"entity": "researcher", "timestamp": "2026-08-20T20:43:03.128Z", "family": "Yalcinkaya", "given": "Ahmet", "initials": "A", "orcid": "0000-0002-1172-3330", "affiliations": ["Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.", "Department of Medical Biochemistry, Hacettepe University Hospital, Ankara, Turkey."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d69855f99eec4f31a547fce683b47c16.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d69855f99eec4f31a547fce683b47c16"}}, "publications": [{"entity": "publication", "iuid": "e01b3ba538af4554bf72dd77a53f4c62", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e01b3ba538af4554bf72dd77a53f4c62.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e01b3ba538af4554bf72dd77a53f4c62"}}, "title": "Autoantibodies neutralizing type I 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"given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/beec83103d55467291f2b8c160df3a04.json"}}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d106604b8ad84e67870302b906a94963.json"}}, {"family": "Borghesi", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-8773-9144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561898f673ca449ebe79aef02751e921.json"}}, {"family": "Rule", "given": "Jody A", "initials": "JA", "orcid": "0000-0002-4019-372X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2779649f7aac411a9b8eb25b0ed9a934.json"}}, {"family": "Lee", "given": "William M", "initials": "WM", "orcid": "0000-0002-2783-5441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0daeba0f2f7f497aa8defa1f568187ee.json"}}, {"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55186a4757e7417389f415061b59ab5c.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/264335517ad94440b23a027fe66f767d.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de52d6ee013c4d18888fed695f547f54.json"}}], "type": "journal article", "published": "2026-03-02", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "223", "issue": "3", "issn-l": "0022-1007"}, "abstract": "Fulminant viral hepatitis (FVH) is a devastating condition caused by hepatotropic viruses such as hepatitis A virus (HAV), hepatitis B virus (HBV), and HSV-1/2. We studied 149 FVH patients (73 males and 76 females, aged 1-76) for blood autoantibodies (auto-Abs) neutralizing type I interferons (IFNs; IFN-\u03b12, -\u03b2, -\u03c9). Six of 16 (37.5%) HSV-triggered FVH patients carried such auto-Abs on admission, including three with a previously known autoimmune disease. These patients contrasted with 133 HAV- (n = 46) or HBV-triggered (n = 87) patients, none of whom had such detectable auto-Abs. Odds ratios for HSV-triggered FVH in individuals with auto-Abs ranged from 35.3 (95% CI: 13.0-96.2; P < 10-7) for those neutralizing only 100 pg/ml IFN-\u03b1/\u03c9 to 1,895 (CI: 448.5-8,002; P < 10-12) for those neutralizing both IFN-\u03b1 and IFN-\u03c9 at 10 ng/ml. Over one third of HSV-triggered FVH cases in this international cohort were due to preexisting auto-Abs. This finding highlights auto-Abs against type I IFNs as a major determinant of HSV-FVH and paves the way for targeted preventive or therapeutic interventions.", "doi": "10.1084/jem.20251760", "pmid": "41348319", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12679989"}, {"db": "pii", "key": "278554"}], "notes": [], "created": "2026-08-20T09:38:20.673Z", "modified": "2026-08-20T09:38:22.004Z"}, {"entity": "publication", "iuid": "7040300b39db43f188e6c2bbc245b852", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7040300b39db43f188e6c2bbc245b852.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7040300b39db43f188e6c2bbc245b852"}}, "title": "Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination.", "authors": [{"family": "Cavalli", "given": "Marco", "initials": "M", "orcid": "0000-0003-1143-1431", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3104b875f2e459093b1e468ba4af556.json"}}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Baron", "given": "Tomasz", "initials": "T"}, {"family": "Yalcinkaya", "given": "Ahmet", "initials": "A", "orcid": "0000-0002-1172-3330", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d69855f99eec4f31a547fce683b47c16.json"}}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P"}, {"family": "Wadelius", "given": "Mia", "initials": "M", "orcid": "0000-0002-6368-2622", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a663f51c194a8f8060b6fa54f11ac6.json"}}], "type": "journal article", "published": "2025-05-08", "journal": {"title": "NPJ Vaccines", "issn": "2059-0105", "volume": "10", "issue": "1", "pages": "88", "issn-l": null}, "abstract": "This genome-wide association study (GWAS) explores the genetic components of severe adverse events following COVID-19 vaccination, with focus on myocarditis and pericarditis. Three SNPs (rs536572545, rs146289966 and rs142297026) near the SCAF11 gene were linked to pericarditis, while rs570375365 in the LRRC4C gene was associated with myocarditis. These findings suggest that genetic variants may influence inflammation pathways, providing a basis for further investigation into the immunological responses triggered by vaccines.", "doi": "10.1038/s41541-025-01139-4", "pmid": "40341528", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12062381"}, {"db": "pii", "key": "10.1038/s41541-025-01139-4"}], "notes": [], "created": "2026-08-20T08:54:47.461Z", "modified": "2026-08-20T08:54:47.602Z"}]}