{"entity": "researcher", "timestamp": "2026-08-20T20:50:16.958Z", "family": "Cerullo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0003-4901-3796", "affiliations": ["Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Finland.", "TRIMM,Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.", "Drug Delivery, Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.", "iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.", "Department of Molecular Medicine and Medical Biotechnology and CEINGE, Naples University 24 Federico II, Naples, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a"}}, "publications": [{"entity": "publication", "iuid": "7bcf8f1340ae4633a4b24c8abc89342a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7bcf8f1340ae4633a4b24c8abc89342a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7bcf8f1340ae4633a4b24c8abc89342a"}}, "title": "Enhancing T-cell recruitment in renal cell carcinoma with cytokine-armed adenoviruses.", "authors": [{"family": "Feodoroff", "given": "Michaela", "initials": "M"}, {"family": "Hamdan", "given": "Firas", "initials": "F"}, {"family": "Antignani", "given": "Gabriella", "initials": "G"}, {"family": "Feola", "given": "Sara", "initials": "S"}, {"family": "Fusciello", "given": "Manlio", "initials": "M"}, {"family": "Russo", "given": "Salvatore", "initials": "S"}, {"family": "Chiaro", "given": "Jacopo", "initials": "J"}, {"family": "V\u00e4lim\u00e4ki", "given": "Katja", "initials": "K"}, {"family": "Pellinen", "given": "Teijo", "initials": "T"}, {"family": "Branca", "given": "Rui M", "initials": "RM"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "D Alessio", "given": "Federica", "initials": "F"}, {"family": "Bottega", "given": "Paolo", "initials": "P"}, {"family": "Stigzelius", "given": "Virpi", "initials": "V"}, {"family": "Sandberg", "given": "Janita", "initials": "J"}, {"family": "Clancy", "given": "Jonna", "initials": "J"}, {"family": "Partanen", "given": "Jukka", "initials": "J"}, {"family": "Malmstedt", "given": "Minna", "initials": "M"}, {"family": "Rannikko", "given": "Antti", "initials": "A"}, {"family": "Pieti\u00e4inen", "given": "Vilja", "initials": "V"}, {"family": "Gr\u00f6nholm", "given": "Mikaela", "initials": "M"}, {"family": "Cerullo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0003-4901-3796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a.json"}}], "type": "journal article", "published": "2024-09-25", "journal": {"title": "Oncoimmunology", "issn": "2162-402X", "volume": "13", "issue": "1", "pages": "2407532", "issn-l": "2162-4011"}, "abstract": "Immunotherapy has emerged as a promising approach for cancer treatment, with oncolytic adenoviruses showing power as immunotherapeutic agents. In this study, we investigated the immunotherapeutic potential of an adenovirus construct expressing CXCL9, CXCL10, or IL-15 in clear cell renal cell carcinoma (ccRCC) tumor models. Our results demonstrated robust cytokine secretion upon viral treatment, suggesting effective transgene expression. Subsequent analysis using resistance-based transwell migration and microfluidic chip assays demonstrated increased T-cell migration in response to chemokine secretion by infected cells in both 2D and 3D cell models. Flow cytometry analysis revealed CXCR3 receptor expression across T-cell subsets, with the highest percentage found on CD8+ T-cells, underscoring their key role in immune cell migration. Alongside T-cells, we also detected NK-cells in the tumors of immunocompromised mice treated with cytokine-encoding adenoviruses. Furthermore, we identified potential immunogenic antigens that may enhance the efficacy and specificity of our armed oncolytic adenoviruses in ccRCC. Overall, our findings using ccRCC cell line, in vivo humanized mice, physiologically relevant PDCs in 2D and patient-derived organoids (PDOs) in 3D suggest that chemokine-armed adenoviruses hold promise for enhancing T-cell migration and improving immunotherapy outcomes in ccRCC. Our study contributes to the development of more effective ccRCC treatment strategies by elucidating immune cell infiltration and activation mechanisms within the tumor microenvironment (TME) and highlights the usefulness of PDOs for predicting clinical relevance and validating novel immunotherapeutic approaches. Overall, our research offers insights into the rational design and optimization of viral-based immunotherapies for ccRCC.", "doi": "10.1080/2162402X.2024.2407532", "pmid": "39351443", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11441019"}, {"db": "pii", "key": "2407532"}], "notes": [], "created": "2026-08-20T09:37:39.062Z", "modified": "2026-08-20T09:37:39.152Z"}, {"entity": "publication", "iuid": "8dbdd622a6684fc09a07dc19fa3bf37f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8dbdd622a6684fc09a07dc19fa3bf37f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8dbdd622a6684fc09a07dc19fa3bf37f"}}, "title": "Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR.", "authors": [{"family": "Manfredi", "given": "Francesco", "initials": "F", "orcid": "0000-0003-2409-944X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f8173a6adb74503a2c2636bc7cd6187.json"}}, {"family": "Stasi", "given": "Lorena", "initials": "L", "orcid": "0000-0001-8044-2295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/103e396d7f714d0eadf42ae463e23006.json"}}, {"family": "Buonanno", "given": "Silvia", "initials": "S"}, {"family": "Marzuttini", "given": "Francesca", "initials": "F"}, {"family": "Noviello", "given": "Maddalena", "initials": "M"}, {"family": "Mastaglio", "given": "Sara", "initials": "S"}, {"family": "Abbati", "given": "Danilo", "initials": "D", "orcid": "0000-0001-8517-7937", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cf52edec41c48e7a085130d6a0f538a.json"}}, {"family": "Potenza", "given": "Alessia", "initials": "A", "orcid": "0000-0003-0298-7315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c2f5b34a8444def99ed10d6922b29b2.json"}}, {"family": "Balestrieri", "given": "Chiara", "initials": "C", "orcid": "0000-0001-7362-3530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c720c467b1714e78bd49b928d1df4717.json"}}, {"family": "Cianciotti", "given": "Beatrice Claudia", "initials": "BC", "orcid": "0000-0002-1337-5915", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b80a1fa9b2d14bfe8ba9e3103fe581d6.json"}}, {"family": "Tassi", "given": "Elena", "initials": "E", "orcid": "0000-0002-2921-8666", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/650c1981b70b4dbf866d21221e0d18b7.json"}}, {"family": "Feola", "given": "Sara", "initials": "S", "orcid": "0000-0002-4012-4310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81e8d2f15fcf4e1aabf7b5a41a977f3f.json"}}, {"family": "Toffalori", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8313-3057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41008f14a9b94192a9cacd2ab0710976.json"}}, {"family": "Punta", "given": "Marco", "initials": "M", "orcid": "0000-0002-0050-0676", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/083075f454224bf1a13724e85cf2bf7c.json"}}, {"family": "Magnani", "given": "Zulma", "initials": "Z", "orcid": "0000-0001-7612-6097", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b56dd0945ff4ebf941b8c1ed107378c.json"}}, {"family": "Camisa", "given": "Barbara", "initials": "B", "orcid": "0000-0002-3867-2457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f967aca004f41e59f1e8e182851d732.json"}}, {"family": "Tiziano", "given": "Elena", "initials": "E", "orcid": "0000-0002-1794-4265", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3818be60d8a34864943b9697aa4e11bd.json"}}, {"family": "Lupo-Stanghellini", "given": "Maria Teresa", "initials": "MT"}, {"family": "Branca", "given": "Rui Mamede", "initials": "RM", "orcid": "0000-0003-3890-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f557cf4f7ed402c8843173ab0bbef04.json"}}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Sikanen", "given": "Tiina M", "initials": "TM", "orcid": "0000-0002-0788-1301", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee477a2ee578421c889c078b35324ce5.json"}}, {"family": "Haapala", "given": "Markus J", "initials": "MJ", "orcid": "0000-0001-7828-8663", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2241723f3734c5390b4fa4014563668.json"}}, {"family": "Cerullo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0003-4901-3796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a.json"}}, {"family": "Casucci", "given": "Monica", "initials": "M", "orcid": "0000-0003-4500-9060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0f5a535676445f5b871cfffd7d98560.json"}}, {"family": "Vago", "given": "Luca", "initials": "L", "orcid": "0000-0003-4247-3175", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e307dc8f3774bbfa97926dd1d1464d1.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F", "orcid": "0000-0003-0873-0123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9631c85f2abe41ecb26c2b96f662c19c.json"}}, {"family": "Bonini", "given": "Chiara", "initials": "C", "orcid": "0000-0002-0772-1674", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72025c797fe74a749bb9b5945a1c4cc1.json"}}, {"family": "Ruggiero", "given": "Eliana", "initials": "E", "orcid": "0000-0002-2954-8278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58dd81c18e944546b46ad24074911897.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "9", "issue": "48", "pages": "eadg8014", "issn-l": "2375-2548"}, "abstract": "To study and then harness the tumor-specific T cell dynamics after allogeneic hematopoietic stem cell transplant, we typed the frequency, phenotype, and function of lymphocytes directed against tumor-associated antigens (TAAs) in 39 consecutive transplanted patients, for 1 year after transplant. We showed that TAA-specific T cells circulated in 90% of patients but display a limited effector function associated to an exhaustion phenotype, particularly in the subgroup of patients deemed to relapse, where exhausted stem cell memory T cells accumulated. Accordingly, cancer-specific cytolytic functions were relevant only when the TAA-specific T cell receptors (TCRs) were transferred into healthy, genome-edited T cells. We then exploited trogocytosis and ligandome-on-chip technology to unveil the specificities of tumor-specific TCRs retrieved from the exhausted T cell pool. Overall, we showed that harnessing circulating TAA-specific and exhausted T cells allow to isolate TCRs against TAAs and previously not described acute myeloid leukemia antigens, potentially relevant for T cell-based cancer immunotherapy.", "doi": "10.1126/sciadv.adg8014", "pmid": "38039364", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10691777"}], "notes": [], "created": "2026-08-20T11:58:45.183Z", "modified": "2026-08-20T11:58:46.172Z"}, {"entity": "publication", "iuid": "6720af3b4faa4eb29c4881909e415f48", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6720af3b4faa4eb29c4881909e415f48.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6720af3b4faa4eb29c4881909e415f48"}}, "title": "Development of mesothelioma-specific oncolytic vaccine exploiting immunopeptidomic analysis of murine and human tumors", "authors": [{"family": "Chiaro", "given": "Jacopo", "initials": "J"}, {"family": "Antignani", "given": "Gabriella", "initials": "G"}, {"family": "Feola", "given": "Sara", "initials": "S", "orcid": "0000-0002-4012-4310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81e8d2f15fcf4e1aabf7b5a41a977f3f.json"}}, {"family": "Feodoroff", "given": "Michaela", "initials": "M", "orcid": "0000-0002-6094-9838", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26e3052a20c64fcb977b22f9876fb32e.json"}}, {"family": "Martins", "given": "Beatriz", "initials": "B"}, {"family": "Cojoc", "given": "Hanne", "initials": "H"}, {"family": "Ferrari", "given": "Valentina", "initials": "V"}, {"family": "Ciampi", "given": "Daniele", "initials": "D"}, {"family": "Ilonen", "given": "Ilkka", "initials": "I", "orcid": "0000-0002-8149-3550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b454bab24bc5448d83e6823d84048bc1.json"}}, {"family": "R\u00e4s\u00e4nen", "given": "Jari", "initials": "J"}, {"family": "M\u00e4yr\u00e4np\u00e4\u00e4", "given": "Mikko", "initials": "M"}, {"family": "Partanen", "given": "Jukka", "initials": "J", "orcid": "0000-0001-6681-4734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d8e2e85ae2c41fc9a9afc0f281e68f1.json"}}, {"family": "Koskela", "given": "Satu", "initials": "S", "orcid": "0000-0001-9258-9163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b489fc9c09b840578305871e75d6cb78.json"}}, {"family": "Kuryk", "given": "Lukasz", "initials": "L", "orcid": "0000-0003-1887-6361", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d16e4a3669242fa8d9590e6861faef5.json"}}, {"family": "Russo", "given": "Salvatore", "initials": "S"}, {"family": "Fusciello", "given": "Manlio", "initials": "M", "orcid": "0000-0002-7166-3018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de1fb2e094ff4d959471a9593544ca51.json"}}, {"family": "Hamdan", "given": "Firas", "initials": "F", "orcid": "0000-0003-4678-7382", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e4b6b79da164ce0bca93cef19a0997f.json"}}, {"family": "Rescigno", "given": "Maria", "initials": "M", "orcid": "0000-0002-6464-509X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db61cb1df7ec4444881b58d32f182ecb.json"}}, {"family": "Gr\u00f6nholm", "given": "Mikaela", "initials": "M"}, {"family": "Branca", "given": "Rui Mamede", "initials": "RM", "orcid": "0000-0003-3890-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f557cf4f7ed402c8843173ab0bbef04.json"}}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Cerullo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0003-4901-3796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a.json"}}], "type": "posted-content", "published": "2022-11-08", "journal": {"issn-l": null}, "abstract": null, "doi": "10.21203/rs.3.rs-2238403/v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:58:36.253Z", "modified": "2026-08-20T12:58:36.719Z"}, {"entity": "publication", "iuid": "d178ec24b2a746abaea0e2d5546a5e44", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d178ec24b2a746abaea0e2d5546a5e44.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d178ec24b2a746abaea0e2d5546a5e44"}}, "title": "A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines.", "authors": [{"family": "Feola", "given": "Sara", "initials": "S", "orcid": "0000-0002-4012-4310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81e8d2f15fcf4e1aabf7b5a41a977f3f.json"}}, {"family": "Chiaro", "given": "Jacopo", "initials": "J"}, {"family": "Martins", "given": "Beatriz", "initials": "B"}, {"family": "Russo", "given": "Salvatore", "initials": "S"}, {"family": "Fusciello", "given": "Manlio", "initials": "M"}, {"family": "Yl\u00f6sm\u00e4ki", "given": "Erkko", "initials": "E"}, {"family": "Bonini", "given": "Chiara", "initials": "C"}, {"family": "Ruggiero", "given": "Eliana", "initials": "E"}, {"family": "Hamdan", "given": "Firas", "initials": "F"}, {"family": "Feodoroff", "given": "Michaela", "initials": "M", "orcid": "0000-0002-6094-9838", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26e3052a20c64fcb977b22f9876fb32e.json"}}, {"family": "Antignani", "given": "Gabriella", "initials": "G"}, {"family": "Viitala", "given": "Tapani", "initials": "T", "orcid": "0000-0001-9074-9450", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccbeaba4a3ad49c7b69f606cdab227e9.json"}}, {"family": "Pesonen", "given": "Sari", "initials": "S"}, {"family": "Gr\u00f6nholm", "given": "Mikaela", "initials": "M"}, {"family": "Branca", "given": "Rui M M", "initials": "RMM"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Cerullo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0003-4901-3796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a.json"}}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "11", "issn-l": "2050-084X"}, "abstract": "Besides the isolation and identification of major histocompatibility complex I-restricted peptides from the surface of cancer cells, one of the challenges is eliciting an effective antitumor CD8+ T-cell-mediated response as part of therapeutic cancer vaccine. Therefore, the establishment of a solid pipeline for the downstream selection of clinically relevant peptides and the subsequent creation of therapeutic cancer vaccines are of utmost importance. Indeed, the use of peptides for eliciting specific antitumor adaptive immunity is hindered by two main limitations: the efficient selection of the most optimal candidate peptides and the use of a highly immunogenic platform to combine with the peptides to induce effective tumor-specific adaptive immune responses. Here, we describe for the first time a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumor cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. This immunopeptidomics-based pipeline was carefully validated in a murine colon tumor model CT26. Specifically, we used state-of-the-art immunoprecipitation and mass spectrometric methodologies to isolate >8000 peptide targets from the CT26 tumor cell line. The selection of the target candidates was then based on two separate approaches: RNAseq analysis and HEX software. The latter is a tool previously developed by Jacopo, 2020, able to identify tumor antigens similar to pathogen antigens in order to exploit molecular mimicry and tumor pathogen cross-reactive T cells in cancer vaccine development. The generated list of candidates (26 in total) was further tested in a functional characterization assay using interferon-\u03b3 enzyme-linked immunospot (ELISpot), reducing the number of candidates to six. These peptides were then tested in our previously described oncolytic cancer vaccine platform PeptiCRAd, a vaccine platform that combines an immunogenic oncolytic adenovirus (OAd) coated with tumor antigen peptides. In our work, PeptiCRAd was successfully used for the treatment of mice bearing CT26, controlling the primary malignant lesion and most importantly a secondary, nontreated, cancer lesion. These results confirmed the feasibility of applying the described pipeline for the selection of peptide candidates and generation of therapeutic oncolytic cancer vaccine, filling a gap in the field of cancer immunotherapy, and paving the way to translate our pipeline into human therapeutic approach.", "doi": "10.7554/eLife.71156", "pmid": "35314027", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8989416"}, {"db": "pii", "key": "71156"}, {"db": "GEO", "key": "GSE111092"}, {"db": "GEO", "key": "GSE92563"}], "notes": [], "created": "2026-08-20T13:54:00.926Z", "modified": "2026-08-20T13:54:01.055Z"}, {"entity": "publication", "iuid": "c34de836d01048a389d4cd68e74a0a08", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c34de836d01048a389d4cd68e74a0a08.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c34de836d01048a389d4cd68e74a0a08"}}, "title": "Author response: A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines", "authors": [{"family": "Feola", "given": "Sara", "initials": "S", "orcid": "0000-0002-4012-4310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81e8d2f15fcf4e1aabf7b5a41a977f3f.json"}}, {"family": "Chiaro", "given": "Jacopo", "initials": "J"}, {"family": "Martins", "given": "Beatriz", "initials": "B"}, {"family": "Russo", "given": "Salvatore", "initials": "S"}, {"family": "Fusciello", "given": "Manlio", "initials": "M"}, {"family": "Yl\u00f6sm\u00e4ki", "given": "Erkko", "initials": "E"}, {"family": "Bonini", "given": "Chiara", "initials": "C"}, {"family": "Ruggiero", "given": "Eliana", "initials": "E"}, {"family": "Hamdan", "given": "Firas", "initials": "F"}, {"family": "Feodoroff", "given": "Michaela", "initials": "M", "orcid": "0000-0002-6094-9838", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26e3052a20c64fcb977b22f9876fb32e.json"}}, {"family": "Antignani", "given": "Gabriella", "initials": "G"}, {"family": "Viitala", "given": "Tapani", "initials": "T", "orcid": "0000-0001-9074-9450", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccbeaba4a3ad49c7b69f606cdab227e9.json"}}, {"family": "Pesonen", "given": "Sari", "initials": "S"}, {"family": "Gr\u00f6nholm", "given": "Mikaela", "initials": "M"}, {"family": "Branca", "given": "Rui MM", "initials": "RM"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Cerullo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0003-4901-3796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a.json"}}], "type": "peer-review", "published": "2022-02-22", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.71156.sa2", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:54:06.276Z", "modified": "2026-08-20T13:54:06.313Z"}]}