{"entity": "researcher", "timestamp": "2026-09-24T22:56:59.909Z", "family": "Hidalgo-Lopez", "given": "Esmeralda", "initials": "E", "orcid": "0000-0001-8521-8970", "affiliations": ["Department of Psychology, University of Salzburg, Salzburg, Austria. esmehl@umich.edu.", "Centre for Cognitive Neuroscience, University of Salzburg, Salzburg, Austria. esmehl@umich.edu.", "Department of Psychology, University of Michigan, Ann Arbor, MI, USA. esmehl@umich.edu.", "Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USA. esmehl@umich.edu."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44dc1e62a654592b2738cb8f0051610.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44dc1e62a654592b2738cb8f0051610"}}, "publications": [{"entity": "publication", "iuid": "bd5d44cffcf6442cb40b91d2dc805683", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bd5d44cffcf6442cb40b91d2dc805683.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bd5d44cffcf6442cb40b91d2dc805683"}}, "title": "Impairment of Executive Functions in Premenstrual Syndrome: State or Trait?", "authors": [{"family": "Gnaiger", "given": "Anna Madeleine", "initials": "AM", "orcid": "0009-0008-3794-9830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fae12746d3045519cb64739833b659d.json"}}, {"family": "Werlein", "given": "Patricia", "initials": "P"}, {"family": "Gruschwitz", "given": "Patricia", "initials": "P"}, {"family": "Siebers", "given": "Magdalena", "initials": "M"}, {"family": "Panzik", "given": "Alina", "initials": "A"}, {"family": "Comasco", "given": "Erika", "initials": "E", "orcid": "0000-0002-2174-2068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f10cd12fd8e4c529264697930ac87b7.json"}}, {"family": "Hidalgo-Lopez", "given": "Esmeralda", "initials": "E", "orcid": "0000-0001-8521-8970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44dc1e62a654592b2738cb8f0051610.json"}}, {"family": "Pletzer", "given": "Belinda", "initials": "B", "orcid": "0000-0002-7277-0923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05a1c7f82ea74291a2b33a0735327908.json"}}], "type": "journal-article", "published": "2026-07-00", "journal": {"title": "Biol Psychiatry Glob Open Sci", "issn": "2667-1743", "volume": "6", "issue": "4", "pages": "100730", "issn-l": null}, "abstract": "The aim of this study was to explore whether cognitive impairments in women with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are phase-dependent or persist across the menstrual cycle. Furthermore, we investigated whether such deficits are limited to working memory (WM) or also extend to inhibitory control (IC).\n\nA total of 105 regularly cycling women between the ages of 19 and 35 years were tested across 3 menstrual cycle phases (mid-follicular, mid-luteal, and late luteal). Premenstrual symptoms were tracked across 2 cycles. Fifty-one women were allocated to the PMS/PMDD group, and 54 women served as control participants. WM and IC were assessed using the n-back and stop signal task, respectively. Hormone levels were determined using saliva samples.\n\nWM deficits in the PMS/PMDD group emerged under high cognitive load and did not vary by cycle phase. The PMS/PMDD group also had significantly longer stop signal reaction times across all cycle phases, with stop signal reaction times positively correlating with premenstrual symptom severity. There was no significant correlation between performance measures and gonadal hormone levels.\n\nCognitive impairments in PMS/PMDD appear to be trait-like and affect both WM and IC. Additionally, IC was significantly associated with premenstrual symptom severity. Executive deficits may underlie difficulties in emotion regulation and are not solely attributable to gonadal hormone levels.", "doi": "10.1016/j.bpsgos.2026.100730", "pmid": "42254277", "labels": {"Erika Comasco": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC13235494"}, {"db": "pii", "key": "S2667-1743(26)00043-1"}], "notes": [], "created": "2026-08-23T09:41:15.934Z", "modified": "2026-09-24T07:08:06.884Z"}, {"entity": "publication", "iuid": "d9ca196ea0a041bea7169b4b23a612a2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d9ca196ea0a041bea7169b4b23a612a2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d9ca196ea0a041bea7169b4b23a612a2"}}, "title": "Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial.", "authors": [{"family": "Hidalgo-Lopez", "given": "Esmeralda", "initials": "E", "orcid": "0000-0001-8521-8970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44dc1e62a654592b2738cb8f0051610.json"}}, {"family": "Engman", "given": "Jonas", "initials": "J", "orcid": "0000-0002-3648-3652", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/141f81bd59d4405192d5f4198e4545c3.json"}}, {"family": "Poromaa", "given": "Inger Sundstr\u00f6m", "initials": "IS", "orcid": "0000-0002-2491-2042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32a89a8ec1084ec3b4f523622f7f2fbb.json"}}, {"family": "Gingnell", "given": "Malin", "initials": "M"}, {"family": "Pletzer", "given": "Belinda", "initials": "B"}], "type": "randomized controlled trial", "published": "2023-06-16", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "13", "issue": "1", "pages": "209", "issn-l": "2158-3188"}, "abstract": "Combined oral contraceptives (COC) are among the most commonly used contraceptive methods worldwide, and mood side effects are the major reason for discontinuation of treatment. We here investigate the directed connectivity patterns associated with the mood side effects of an androgenic COC in a double-blind randomized, placebo-controlled trial in women with a history of affective COC side effects (n = 34). We used spectral dynamic causal modeling on a triple network model consisting of the default mode network (DMN), salience network (SN) and executive control network (ECN). Within this framework, we assessed the treatment-related changes in directed connectivity associated with adverse mood side effects. Overall, during COC use, we found a pattern of enhanced connectivity within the DMN and decreased connectivity within the ECN. The dorsal anterior cingulate cortex (SN) mediates an increased recruitment of the DMN by the ECN during treatment. Mood lability was the most prominent COC-induced symptom and also arose as the side effect most consistently related to connectivity changes. Connections that were related to increased mood lability showed increased connectivity during COC treatment, while connections that were related to decreased mood lability showed decreased connectivity during COC treatment. Among these, the connections with the highest effect size could also predict the participants' treatment group above chance.", "doi": "10.1038/s41398-023-02470-x", "pmid": "37328507", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10276024"}, {"db": "pii", "key": "10.1038/s41398-023-02470-x"}], "notes": [], "created": "2026-09-23T11:11:25.404Z", "modified": "2026-09-23T11:11:25.562Z"}, {"entity": "publication", "iuid": "f4e57bdddc0f4166adb310ea25cbfec3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f4e57bdddc0f4166adb310ea25cbfec3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f4e57bdddc0f4166adb310ea25cbfec3"}}, "title": "Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial", "authors": [{"family": "Hidalgo-Lopez", "given": "Esmeralda", "initials": "E", "orcid": "0000-0001-8521-8970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44dc1e62a654592b2738cb8f0051610.json"}}, {"family": "Engman", "given": "Jonas", "initials": "J"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I", "orcid": "0000-0002-2491-2042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32a89a8ec1084ec3b4f523622f7f2fbb.json"}}, {"family": "Gingnell", "given": "Malin", "initials": "M", "orcid": "0000-0001-5310-6843", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d3c7da5763b422e8991cda7be16aca2.json"}}, {"family": "Pletzer", "given": "Belinda", "initials": "B", "orcid": "0000-0002-7277-0923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05a1c7f82ea74291a2b33a0735327908.json"}}], "type": "posted-content", "published": "2022-08-12", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.08.11.22278664", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T15:20:30.696Z", "modified": "2026-09-23T15:20:30.798Z"}]}