{"entity": "researcher", "timestamp": "2026-09-24T08:35:47.192Z", "family": "Martinez-Climent", "given": "Jose Angel", "initials": "JA", "orcid": "0000-0002-7938-3950", "affiliations": ["Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.", "Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d43329ea769f4fcf83f8cad698d49d05.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d43329ea769f4fcf83f8cad698d49d05"}}, "publications": [{"entity": "publication", "iuid": "38aa2f4e10684b4bb46ba0e87f09501f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/38aa2f4e10684b4bb46ba0e87f09501f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/38aa2f4e10684b4bb46ba0e87f09501f"}}, "title": "Characterization of the bone marrow architecture of multiple myeloma using spatial transcriptomics.", "authors": [{"family": "Mui\u00f1os-Lopez", "given": "Emma", "initials": "E", "orcid": "0000-0002-6618-4135", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cac709bdc9442adb241d448a15321eb.json"}}, {"family": "Lopez-Perez", "given": "Ana Rosa", "initials": "AR"}, {"family": "Sudupe", "given": "Laura", "initials": "L"}, {"family": "Vilas-Zornoza", "given": "Amaia", "initials": "A"}, {"family": "Sarvide", "given": "Sarai", "initials": "S"}, {"family": "Ripalda-Cemborain", "given": "Purificacion", "initials": "P"}, {"family": "Aguirre-Ruiz", "given": "Paula", "initials": "P"}, {"family": "Martin-Uriz", "given": "Patxi San", "initials": "PS", "orcid": "0000-0003-1483-4279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7165cce0460347a297f30bd381a3b817.json"}}, {"family": "Larrayoz", "given": "Marta", "initials": "M"}, {"family": "Alvarez-Gigli", "given": "Laura", "initials": "L"}, {"family": "Abengozar-Muela", "given": "Marta", "initials": "M"}, {"family": "Cenzano", "given": "Itziar", "initials": "I", "orcid": "0000-0002-9030-3069", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7868914b004b46a1bd4f78e80f387ac5.json"}}, {"family": "C\u00f3cera", "given": "Miguel", "initials": "M"}, {"family": "Ruiz", "given": "Javier", "initials": "J"}, {"family": "Sancho", "given": "Ignacio", "initials": "I"}, {"family": "Bantan", "given": "Azari", "initials": "A"}, {"family": "Kurowska", "given": "Aleksandra", "initials": "A", "orcid": "0000-0001-5950-0358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e484660a5ece401790874403619911da.json"}}, {"family": "Ye", "given": "Jin", "initials": "J"}, {"family": "Newton", "given": "Phillip T", "initials": "PT", "orcid": "0000-0003-2142-1798", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07e490d4b3da4741b490395399f1b8c1.json"}}, {"family": "Paiva", "given": "Bruno", "initials": "B"}, {"family": "Tamariz-Amador", "given": "Luis Esteban", "initials": "LE"}, {"family": "Rodriguez-Madoz", "given": "Juan R", "initials": "JR", "orcid": "0000-0003-4327-1866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/032e1bae16a541928dbf35e08694d686.json"}}, {"family": "Lagani", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-6552-6076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8832e0f50e14a23875a47949200ca6c.json"}}, {"family": "Tegner", "given": "Jesper", "initials": "J", "orcid": "0000-0002-9568-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b115e5faf68a4acbb6f947c711fd37ec.json"}}, {"family": "Saez", "given": "Borja", "initials": "B"}, {"family": "Martinez-Climent", "given": "Jose Angel", "initials": "JA", "orcid": "0000-0002-7938-3950", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d43329ea769f4fcf83f8cad698d49d05.json"}}, {"family": "Calvo", "given": "Isabel A", "initials": "IA", "orcid": "0000-0001-6619-4571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7fa7ce0de9074d21a92dc8667b3eb6b6.json"}}, {"family": "Gomez-Cabrero", "given": "David", "initials": "D", "orcid": "0000-0003-4186-3788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2f7905f6b864d3286b28b99dbb59627.json"}}, {"family": "Prosper", "given": "Felipe", "initials": "F", "orcid": "0000-0001-6115-8790", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b062035045714ecd9d6cbca6fc60d433.json"}}], "type": "journal article", "published": "2025-11-20", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "8", "issue": "1", "pages": "1620", "issn-l": "2399-3642"}, "abstract": "The bone marrow (BM) is a complex and compartmentalized tissue where spatial context plays a critical role in regulating cell behavior, signaling, and disease progression. To capture these dynamics, we apply spatial transcriptomics using the Visium Spatial Gene Expression platform on formalin-fixed paraffin-embedded (FFPE) BM sections from both healthy and Multiple Myeloma (MM) mouse models, as well as MM patient samples. Overcoming the technical challenges of working with mineralized long bone tissue, we develop a custom analytical framework integrating spatial and single-cell transcriptomic data to map cellular composition and interactions in situ. This approach enables the spatial characterization of transcriptionally heterogeneous malignant plasma cells (MM-PC) and their surrounding microenvironments. We identify spatially distinct gene programs linked to MM pathogenesis, including signatures of NETosis and IL-17 signalling, which are reduced in MM-PC-rich regions. Additionally, a transition gradient from effector to exhausted T cell phenotype is associated with increased remoteness from MM-PC. These spatial patterns are identified in FFPE BM biopsies from MM patients with varying tumor burdens. In summary, our study demonstrates both the capabilities and limitations of Visium technology in characterizing spatially regulated mechanisms underlying MM pathogenesis.", "doi": "10.1038/s42003-025-08975-z", "pmid": "41266582", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12634688"}, {"db": "pii", "key": "10.1038/s42003-025-08975-z"}], "notes": [], "created": "2026-09-23T11:37:31.313Z", "modified": "2026-09-23T11:37:31.808Z"}]}