{"entity": "researcher", "timestamp": "2026-08-25T13:47:29.935Z", "family": "G\u00f6ransson", "given": "Ulf", "initials": "U", "orcid": "0000-0002-5005-9612", "affiliations": ["Division of Pharmacognosy, Department of Medicinal Chemistry , Uppsala University , Biomedical Centre , Box 574, SE-75123 Uppsala , Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ca05c134b9434abe1b75853e9cd1ec.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ca05c134b9434abe1b75853e9cd1ec"}}, "publications": [{"entity": "publication", "iuid": "a58522e7f47b4537be5926a8f07a3aac", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a58522e7f47b4537be5926a8f07a3aac.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a58522e7f47b4537be5926a8f07a3aac"}}, "title": "Interpopulational Variation in Cyclotide Production in Heavy-Metal-Treated Pseudometallophyte (Viola tricolor L.).", "authors": [{"family": "Miszczak", "given": "Rebecca", "initials": "R", "orcid": "0000-0002-5010-476X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/240fa13e6aae4884ab32c56b8c4140bf.json"}}, {"family": "Slazak", "given": "Blazej", "initials": "B", "orcid": "0000-0002-4143-6543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39d9c14d899f4fb98554b9b560bf1007.json"}}, {"family": "Sychta", "given": "Klaudia", "initials": "K", "orcid": "0000-0001-7368-1570", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a938a49315646eaab19cb7a60f6d159.json"}}, {"family": "G\u00f6ransson", "given": "Ulf", "initials": "U", "orcid": "0000-0002-5005-9612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ca05c134b9434abe1b75853e9cd1ec.json"}}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "S\u0142omka", "given": "Aneta", "initials": "A", "orcid": "0000-0001-5682-8323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da20aa45d0c340e8a41b72777f49de7d.json"}}], "type": "journal article", "published": "2025-02-05", "journal": {"title": "Plants (Basel)", "issn": "2223-7747", "volume": "14", "issue": "3", "issn-l": null}, "abstract": "It remains an open question whether violets use universal mechanisms, such as the production of metallothioneins, phytochelatins, and organic acids and/or rely on specific mechanisms like the production of antimicrobial cyclic peptides (cyclotides) for heavy metal tolerance. To contribute to the understanding of the role of cyclotides, we used seed-derived plants from metallicolous (M) and non-metallicolous (NM) populations of Viola tricolor, a pseudometallophyte tolerant to Zn and Pb. Eight- to ten-week-old plants were treated with 1000 \u03bcM of Zn or Pb for 3 or 7 days and subsequently measured for cyclotides and heavy metal content using MALDI-MS and Atomic Absorption Spectrometry (AAS), respectively. Individuals from the M population accumulated a similar amount of Zn but occasionally more Pb in comparison with the NM population. Of the 18 different cyclotides included in the analysis, some showed statistically significant changes under the heavy metal treatment. In general, a decrease was observed in the M population, whereas an increase was observed in the NM population (except for the 3-day treatment with Zn). The day of treatment and dose of metal and their interaction played a crucial role in the explained variance for cyclotides produced by the M individuals but not for the NM plants. This unravels the importance of this antimicrobial compound in heavy metal tolerance and indicates that, in V. tricolor, cyclotides are involved in heavy metal tolerance, but specimens from two populations have developed different strategies and tolerance mechanisms involving cyclotides to mitigate heavy metal stress.", "doi": "10.3390/plants14030471", "pmid": "39943033", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11820275"}, {"db": "pii", "key": "plants14030471"}], "notes": [], "created": "2026-08-21T13:05:05.982Z", "modified": "2026-08-21T13:05:06.286Z"}, {"entity": "publication", "iuid": "45096a427cff4a7599a78d85a9ae25c0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/45096a427cff4a7599a78d85a9ae25c0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/45096a427cff4a7599a78d85a9ae25c0"}}, "title": "Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis.", "authors": [{"family": "Gunasekera", "given": "Sunithi", "initials": "S"}, {"family": "Fernandes-Cerqueira", "given": "C\u00e1tia", "initials": "C"}, {"family": "Wennmalm", "given": "Stefan", "initials": "S"}, {"family": "W\u00e4h\u00e4maa", "given": "Heidi", "initials": "H"}, {"family": "Sommarin", "given": "Yngve", "initials": "Y"}, {"family": "Catrina", "given": "Anca I", "initials": "AI"}, {"family": "Jakobsson", "given": "Per-Johan", "initials": "PJ"}, {"family": "G\u00f6ransson", "given": "Ulf", "initials": "U", "orcid": "0000-0002-5005-9612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ca05c134b9434abe1b75853e9cd1ec.json"}}], "type": "journal article", "published": "2018-06-15", "journal": {"title": "ACS chemical biology", "issn": "1554-8937", "volume": "13", "issue": "6", "pages": "1525-1535", "issn-l": "1554-8929"}, "abstract": "The occurrence of autoantibodies is a hallmark of rheumatoid arthritis, specifically those autoantibodies targeting proteins containing the arginine-derived amino acid citrulline. There is strong evidence showing that the occurrence of anticitrullinated protein/peptide antibodies (ACPA) are involved in disease progression, and ACPA was recently shown to induce pain in animals. Here, we explore a novel concept useful for research, diagnostics, and possibly therapy of autoimmune diseases, namely, to directly target and neutralize autoantibodies using peptide binders. A high-affinity peptide-based scavenger of ACPA was developed by grafting a citrullinated epitope derived from human fibrinogen into a naturally occurring stable peptide scaffold. The best scavenger comprises the truncated epitope \u03b1-fibrinogen, [Cit573]fib(566-580), grafted into the scaffold sunflower trypsin inhibitor-1, SFTI-1. The final peptide demonstrates low nanomolar apparent affinity and superior stability.", "doi": "10.1021/acschembio.8b00118", "pmid": "29630823", "labels": [], "xrefs": [], "notes": [], "created": "2019-01-17T13:51:02.183Z", "modified": "2026-08-21T11:35:42.256Z"}]}