{"entity": "researcher", "timestamp": "2026-08-26T22:48:48.606Z", "family": "Meyer", "given": "Thomas F", "initials": "TF", "orcid": "0000-0002-6120-8679", "affiliations": ["Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany. meyer@mpiib-berlin.mpg.de."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2677b1204584774b2572647026f75c2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2677b1204584774b2572647026f75c2"}}, "publications": [{"entity": "publication", "iuid": "729cbf05504443529c9a08fd90c94c30", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/729cbf05504443529c9a08fd90c94c30.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/729cbf05504443529c9a08fd90c94c30"}}, "title": "Colibactin DNA-damage signature indicates mutational impact in colorectal cancer.", "authors": [{"family": "Dziuba\u0144ska-Kusibab", "given": "Paulina J", "initials": "PJ"}, {"family": "Berger", "given": "Hilmar", "initials": "H", "orcid": "0000-0002-6304-4946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c1923296ba403b9d3af1b0b752cb62.json"}}, {"family": "Battistini", "given": "Federica", "initials": "F"}, {"family": "Bouwman", "given": "Britta A M", "initials": "BAM", "orcid": "0000-0002-9827-9497", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26e2947dca1e4467aef5342387c5ca7d.json"}}, {"family": "Iftekhar", "given": "Amina", "initials": "A"}, {"family": "Katainen", "given": "Riku", "initials": "R"}, {"family": "Cajuso", "given": "Tatiana", "initials": "T"}, {"family": "Crosetto", "given": "Nicola", "initials": "N"}, {"family": "Orozco", "given": "Modesto", "initials": "M"}, {"family": "Aaltonen", "given": "Lauri A", "initials": "LA"}, {"family": "Meyer", "given": "Thomas F", "initials": "TF", "orcid": "0000-0002-6120-8679", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2677b1204584774b2572647026f75c2.json"}}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "26", "issue": "7", "pages": "1063-1069", "issn-l": "1078-8956"}, "abstract": "The mucosal epithelium is a common target of damage by chronic bacterial infections and the accompanying toxins, and most cancers originate from this tissue. We investigated whether colibactin, a potent genotoxin1 associated with certain strains of Escherichia coli2, creates a specific DNA-damage signature in infected human colorectal cells. Notably, the genomic contexts of colibactin-induced DNA double-strand breaks were enriched for an AT-rich hexameric sequence motif, associated with distinct DNA-shape characteristics. A survey of somatic mutations at colibactin target sites of several thousand cancer genomes revealed notable enrichment of this motif in colorectal cancers. Moreover, the exact double-strand-break loci corresponded with mutational hot spots in cancer genomes, reminiscent of a trinucleotide signature previously identified in healthy colorectal epithelial cells3. The present study provides evidence for the etiological role of colibactin in human cancer.", "doi": "10.1038/s41591-020-0908-2", "pmid": "32483361", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41591-020-0908-2"}], "notes": [], "created": "2026-08-21T11:52:08.604Z", "modified": "2026-08-21T11:52:08.785Z"}]}