{"entity": "researcher", "timestamp": "2026-08-28T00:12:27.860Z", "family": "Campomanes", "given": "Pablo", "initials": "P", "orcid": "0000-0001-9229-8323", "affiliations": ["Department of Biology, University of Fribourg, Fribourg, Switzerland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/d03510956eb54126ac7575344604ed0f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/d03510956eb54126ac7575344604ed0f"}}, "publications": [{"entity": "publication", "iuid": "1ce102abef3b4342a65b2b7626e543f4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1ce102abef3b4342a65b2b7626e543f4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1ce102abef3b4342a65b2b7626e543f4"}}, "title": "In situ architecture of the ER-mitochondria encounter structure.", "authors": [{"family": "Wozny", "given": "Michael R", "initials": "MR"}, {"family": "Di Luca", "given": "Andrea", "initials": "A"}, {"family": "Morado", "given": "Dustin R", "initials": "DR"}, {"family": "Picco", "given": "Andrea", "initials": "A", "orcid": "0000-0003-2548-9183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f03e47311b4a425c8987be449f9a2983.json"}}, {"family": "Khaddaj", "given": "Rasha", "initials": "R"}, {"family": "Campomanes", "given": "Pablo", "initials": "P", "orcid": "0000-0001-9229-8323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d03510956eb54126ac7575344604ed0f.json"}}, {"family": "Ivanovi\u0107", "given": "Lazar", "initials": "L"}, {"family": "Hoffmann", "given": "Patrick C", "initials": "PC", "orcid": "0000-0003-3421-6363", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db34ded2ba0a4589ab8ffa5f4d758243.json"}}, {"family": "Miller", "given": "Elizabeth A", "initials": "EA", "orcid": "0000-0002-1033-8369", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0d23b5de2cc406694d4bdd13339b707.json"}}, {"family": "Vanni", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2146-1140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eed625e5296a442e9ce3d346f5a4c128.json"}}, {"family": "Kukulski", "given": "Wanda", "initials": "W", "orcid": "0000-0002-2778-3936", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ffec601b54545af9b2556af13d6a92a.json"}}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "618", "issue": "7963", "pages": "188-192", "issn-l": "0028-0836"}, "abstract": "The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane biogenesis that rely on lipid exchange via membrane contact sites1-3, but the underpinning mechanisms remain poorly understood. In yeast, tethering and lipid transfer between the two organelles is mediated by the endoplasmic reticulum-mitochondria encounter structure (ERMES), a four-subunit complex of unresolved stoichiometry and architecture4-6. Here we determined the molecular organization of ERMES within Saccharomyces cerevisiae cells using integrative structural biology by combining quantitative live imaging, cryo-correlative microscopy, subtomogram averaging and molecular modelling. We found that ERMES assembles into approximately 25 discrete bridge-like complexes distributed irregularly across a contact site. Each bridge consists of three synaptotagmin-like mitochondrial lipid binding protein domains oriented in a zig-zag arrangement. Our molecular model of ERMES reveals a pathway for lipids. These findings resolve the in situ supramolecular architecture of a major inter-organelle lipid transfer machinery and provide a basis for the mechanistic understanding of lipid fluxes in eukaryotic cells.", "doi": "10.1038/s41586-023-06050-3", "pmid": "37165187", "labels": [], "xrefs": [{"db": "mid", "key": "EMS173552"}, {"db": "pmc", "key": "PMC7614606"}, {"db": "pii", "key": "10.1038/s41586-023-06050-3"}], "notes": [], "created": "2026-08-21T11:51:08.563Z", "modified": "2026-08-21T11:51:08.801Z"}]}