{"entity": "researcher", "timestamp": "2026-03-09T09:28:19.045Z", "family": "Wang", "given": "Chao", "initials": "C", "orcid": "0000-0003-3936-4023", "affiliations": ["Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfac9dfcdfc04a88b002ffe4ee8a5bb4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfac9dfcdfc04a88b002ffe4ee8a5bb4"}}, "publications": [{"entity": "publication", "iuid": "4c01528e8841434099155d393ffd4cc3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4c01528e8841434099155d393ffd4cc3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4c01528e8841434099155d393ffd4cc3"}}, "title": "Ultraprocessed Food Consumption and Risk of Early-Onset Colorectal Cancer Precursors Among Women", "authors": [{"family": "Wang", "given": "Chen", "initials": "C", "orcid": "0000-0003-3936-4023", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfac9dfcdfc04a88b002ffe4ee8a5bb4.json"}}, {"family": "Du", "given": "Mengxi", "initials": "M"}, {"family": "Kim", "given": "Hanseul", "initials": "H"}, {"family": "Nguyen", "given": "Long H", "initials": "LH"}, {"family": "Wang", "given": "Qiao Li", "initials": "QL", "orcid": "0000-0003-4152-7821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/357edb3116b64ad5aa929dcb7d07a1be.json"}}, {"family": "Drew", "given": "David A", "initials": "DA"}, {"family": "Leeming", "given": "Emily R", "initials": "ER"}, {"family": "Khandpur", "given": "Neha", "initials": "N"}, {"family": "Sun", "given": "Qi", "initials": "Q", "orcid": "0000-0002-8480-1563", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a65407257ac4518ac5cb19317ee3b32.json"}}, {"family": "Zong", "given": "Xiaoyu", "initials": "X", "orcid": "0000-0001-5646-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1250f735b6b4cd2a6873a9208e862a8.json"}}, {"family": "Gweon", "given": "Tae Geun", "initials": "TG"}, {"family": "Ogino", "given": "Shuji", "initials": "S"}, {"family": "Ng", "given": "Kimmie", "initials": "K", "orcid": "0000-0003-0631-1494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00bc0d97cfc44e9398c9bf1db5783402.json"}}, {"family": "Berry", "given": "Sarah", "initials": "S"}, {"family": "Giovannucci", "given": "Edward L", "initials": "EL", "orcid": "0000-0002-6123-0219", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4958abe8f85b417cae3009a782e9f69d.json"}}, {"family": "Song", "given": "Mingyang", "initials": "M"}, {"family": "Cao", "given": "Yin", "initials": "Y", "orcid": "0000-0001-9835-7662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a34eb276a5514342adb104aa5df642c9.json"}}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}], "type": "journal-article", "published": "2025-11-13", "journal": {"title": "JAMA Oncol", "issn": "2374-2445", "issn-l": null}, "abstract": "Early-onset colorectal cancer (EOCRC) (diagnosed age <50 years) incidence is increasing globally, in parallel with increased consumption of ultraprocessed foods (UPFs). The role of UPFs in early-onset colorectal neoplasia remains underexplored.\n\nTo evaluate the association between UPF consumption and risk of EOCRC precursors.\n\nThis prospective cohort study included participants of the Nurses' Health Study II, an ongoing US prospective cohort of female registered nurses established in 1989. Participants were followed up from June 1, 1991, through June 1, 2015. Data were analyzed from October 2024 to July 2025. UPF intake, derived from food-frequency questionnaires administered every 4 years and classified using the Nova system, was modeled as quintiles of energy-adjusted servings per day. Of the nurses enrolled, those who had completed the baseline 1991 food-frequency questionnaire, undergone at least 1 lower endoscopy before age 50 years after baseline, had no history of cancer (except for nonmelanoma skin cancer) before endoscopy, and no colorectal polyp or inflammatory bowel disease were included.\n\nIncidence of EOCRC precursors, including conventional adenomas and serrated lesions, confirmed via medical records and pathology reports. Multivariable logistic regression models with generalized estimating equations for clustered data were used to estimate adjusted odds ratios (AORs) and 95% CIs, accounting for known and putative risk factors.\n\nAmong 29 105 female participants (mean [SD] age, 45.2 [4.5] years) over 24 years of follow-up, 1189 cases were documented of early-onset conventional adenomas and 1598 serrated lesions. UPFs provided 34.8% of total daily calories (median, 5.7 [IQR, 4.5-7.4] servings per day). Participants with higher UPF intake had an increased risk of early-onset conventional adenomas (highest vs lowest intake: AOR, 1.45; 95% CI, 1.19-1.77; overall P < .001) but not serrated lesions (AOR, 1.04; 95% CI, 0.89-1.22; P = .48 for trend). Findings were consistent after further adjustment for body mass index, type 2 diabetes, dietary factors (fiber, folate, calcium, and vitamin D), and Alternative Healthy Eating Index-2010 score.\n\nIn this study, higher UPF intake was associated with increased risk of early-onset colorectal conventional adenomas. These data highlight the important role of UPFs in early-onset colorectal tumorigenesis and support improving dietary quality as a strategy to mitigate the increasing burden of EOCRC.", "doi": "10.1001/jamaoncol.2025.4777", "pmid": "41231486", "labels": {"DDLS Fellow": null, "Qiaoli Wang": null}, "xrefs": [{"db": "pmc", "key": "PMC12616530"}, {"db": "pii", "key": "2841354"}], "notes": [], "created": "2025-11-28T12:26:13.403Z", "modified": "2026-01-16T07:28:50.639Z"}, {"entity": "publication", "iuid": "2765baf826544e44bc56796164091f51", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2765baf826544e44bc56796164091f51.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2765baf826544e44bc56796164091f51"}}, "title": "A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken.", "authors": [{"family": "Bi", "given": "Huijuan", "initials": "H"}, {"family": "Tranell", "given": "Jonas", "initials": "J"}, {"family": "Harper", "given": "Dawn C", "initials": "DC"}, {"family": "Lin", "given": "Weifeng", "initials": "W", "orcid": "0000-0001-8330-7072", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8dc89fea7f5416db821207f7a877ef8.json"}}, {"family": "Li", "given": "Jingyi", "initials": "J"}, {"family": "Hellstr\u00f6m", "given": "Anders R", "initials": "AR"}, {"family": "Larsson", "given": "M\u00e5rten", "initials": "M"}, {"family": "Rubin", "given": "Carl-Johan", "initials": "CJ"}, {"family": "Wang", "given": "Chao", "initials": "C", "orcid": "0000-0003-3936-4023", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfac9dfcdfc04a88b002ffe4ee8a5bb4.json"}}, {"family": "Sayyab", "given": "Shumaila", "initials": "S"}, {"family": "Kerje", "given": "Susanne", "initials": "S"}, {"family": "Bed'hom", "given": "Bertrand", "initials": "B", "orcid": "0000-0002-0825-0886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/852272555fbf475da45d338fad9ccf3a.json"}}, {"family": "Gourichon", "given": "David", "initials": "D"}, {"family": "Ito", "given": "Shosuke", "initials": "S", "orcid": "0000-0001-9182-5144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f96a380aea141bd98199f7cd5f0d0d0.json"}}, {"family": "Wakamatsu", "given": "Kazumasa", "initials": "K", "orcid": "0000-0003-1748-9001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2114720f8b504f848c6a9844e6ec91e3.json"}}, {"family": "Tixier-Boichard", "given": "Mich\u00e8le", "initials": "M"}, {"family": "Marks", "given": "Michael S", "initials": "MS"}, {"family": "Globisch", "given": "Daniel", "initials": "D", "orcid": "0000-0002-4526-5788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2cd75219d6894d6b851e202eaa40fc5f.json"}}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c8202937eda401fa0d07f583589359d.json"}}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "19", "issue": "4", "pages": "e1010724", "issn-l": "1553-7390"}, "abstract": "The biochemical pathway regulating the synthesis of yellow/red pheomelanin is less well characterized than the synthesis of black/brown eumelanin. Inhibitor of gold (IG phenotype) is a plumage colour variant in chicken that provides an opportunity to further explore this pathway since the recessive allele (IG) at this locus is associated with a defect in the production of pheomelanin. IG/IG homozygotes display a marked dilution of red pheomelanin pigmentation, whilst black pigmentation (eumelanin) is only slightly affected. Here we show that a 2-base pair insertion (frame-shift mutation) in the 5th exon of the Catechol-O-methyltransferase containing domain 1 gene (COMTD1), expected to cause a complete or partial loss-of-function of the COMTD1 enzyme, shows complete concordance with the IG phenotype within and across breeds. We show that the COMTD1 protein is localized to mitochondria in pigment cells. Knockout of Comtd1 in a mouse melanocytic cell line results in a reduction in pheomelanin metabolites and significant alterations in metabolites of glutamate/glutathione, riboflavin, and the tricarboxylic acid cycle. Furthermore, COMTD1 overexpression enhanced cellular proliferation following chemical-induced transfection, a potential inducer of oxidative stress. These observations suggest that COMTD1 plays a protective role for melanocytes against oxidative stress and that this supports their ability to produce pheomelanin.", "doi": "10.1371/journal.pgen.1010724", "pmid": "37068079", "labels": {"Daniel Globisch": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10138217"}, {"db": "pii", "key": "PGENETICS-D-22-01448"}], "notes": [], "created": "2023-05-16T07:15:03.044Z", "modified": "2023-05-16T07:15:03.230Z"}]}