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"https://publications-affiliated.scilifelab.se/researcher/0daeba0f2f7f497aa8defa1f568187ee.json"}}, {"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55186a4757e7417389f415061b59ab5c.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/264335517ad94440b23a027fe66f767d.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de52d6ee013c4d18888fed695f547f54.json"}}], "type": "journal article", "published": "2026-03-02", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "223", "issue": "3", "issn-l": "0022-1007"}, "abstract": "Fulminant viral hepatitis (FVH) is a devastating condition caused by hepatotropic viruses such as hepatitis A virus (HAV), hepatitis B virus (HBV), and HSV-1/2. We studied 149 FVH patients (73 males and 76 females, aged 1-76) for blood autoantibodies (auto-Abs) neutralizing type I interferons (IFNs; IFN-\u03b12, -\u03b2, -\u03c9). Six of 16 (37.5%) HSV-triggered FVH patients carried such auto-Abs on admission, including three with a previously known autoimmune disease. These patients contrasted with 133 HAV- (n = 46) or HBV-triggered (n = 87) patients, none of whom had such detectable auto-Abs. Odds ratios for HSV-triggered FVH in individuals with auto-Abs ranged from 35.3 (95% CI: 13.0-96.2; P < 10-7) for those neutralizing only 100 pg/ml IFN-\u03b1/\u03c9 to 1,895 (CI: 448.5-8,002; P < 10-12) for those neutralizing both IFN-\u03b1 and IFN-\u03c9 at 10 ng/ml. Over one third of HSV-triggered FVH cases in this international cohort were due to preexisting auto-Abs. This finding highlights auto-Abs against type I IFNs as a major determinant of HSV-FVH and paves the way for targeted preventive or therapeutic interventions.", "doi": "10.1084/jem.20251760", "pmid": "41348319", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12679989"}, {"db": "pii", "key": "278554"}], "notes": [], "created": "2026-08-20T09:38:20.673Z", "modified": "2026-08-20T09:38:22.004Z"}]}